anti-Insulin Receptor Substrate 1 (IRS1) Antikörper

Bezeichnung:
anti-Insulin Receptor Substrate 1 Antikörper (IRS1)
Auf www.antikoerper-online.de finden Sie aktuell 586 Insulin Receptor Substrate 1 (IRS1) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Insulin Receptor Substrate 1 Kits (50) und Insulin Receptor Substrate 1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 666 Insulin Receptor Substrate 1 Produkte verfügbar.
Synonyme:
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

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Am meisten referenzierte anti-Insulin Receptor Substrate 1 Antikörper

  1. Human Polyclonal IRS1 Primary Antibody für IHC (p), WB - ABIN196980 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Zeige alle 4 Referenzen für 196980

  2. Human Polyclonal IRS1 Primary Antibody für IF, IHC (p) - ABIN197466 : Tzatsos, Kandror: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. in Molecular and cellular biology 2005 (PubMed)
    Zeige alle 4 Referenzen für 197466

  3. Human Polyclonal IRS1 Primary Antibody für IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. in PLoS ONE 2014 (PubMed)
    Zeige alle 2 Referenzen für 1531876

  4. Human Polyclonal IRS1 Primary Antibody für IF, ELISA - ABIN1531877 : Araki, Sun, Haag, Chuang, Zhang, Yang-Feng, White, Kahn: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. in Diabetes 1993 (PubMed)

  5. Human Polyclonal IRS1 Primary Antibody für IF (p), IHC (p) - ABIN749873 : Luo, Yang, Tang, Yao, Kong, He, Zhou: Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats. in International immunopharmacology 2015 (PubMed)

  6. Human Polyclonal IRS1 Primary Antibody für ELISA, WB - ABIN129580 : Shah, Hunter: Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. in Molecular and cellular biology 2006 (PubMed)

Weitere Antikörper gegen Insulin Receptor Substrate 1 Interaktionspartner

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. miR (zeige MYLIP Antikörper)-146a-5p targets porcine insulin receptor (zeige INSR Antikörper) and could inhibit its protein expression.

  2. TBC1D4 (zeige TBC1D4 Antikörper), insulin receptor (zeige INSR Antikörper) and GLUT4 (zeige SLC2A4 Antikörper) showed altered expression in some tissues in pre-diabetic pigs.

  3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.

  2. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  3. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  4. The results suggest that high glucose compromises the insulin (zeige INS Antikörper) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  5. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  6. IRS-1 and IRS-2 (zeige IRS2 Antikörper) signaling interaction with the microtubule cytoskeleton and its response to AKT (zeige AKT1 Antikörper) determines the response to microtubule disruption in breast carcinoma cells

  7. Findings suggest that the induction of microRNA miR (zeige MLXIP Antikörper)-1271 by saturated fatty acid palmitate promotes the development of insulin (zeige INS Antikörper) resistance by targeting insulin receptor (INSR (zeige INSR Antikörper)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (zeige INS Antikörper), IRS2 (zeige IRS2 Antikörper), PPAR-G (zeige ARF6 Antikörper) and CAPN10 (zeige CAPN10 Antikörper) failed to show any association with PCOS in our studied population.

  9. Consistent with these observations, LPIN1 (zeige LPIN1 Antikörper) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (zeige LPIN1 Antikörper) may be a promising drug target for anticancer therapy

  10. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (zeige IRS2 Antikörper) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (zeige INSR Antikörper) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (zeige MLXIP Antikörper)-342

  2. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. In conclusion, we have identified that ARL15 acts as an insulin (zeige INS Antikörper)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (zeige PDPK1 Antikörper)/AKT (zeige AKT1 Antikörper) insulin (zeige INS Antikörper) pathway by interacting with its GAP ASAP2 (zeige ASAP2 Antikörper) and activating PDPK1 (zeige PDPK1 Antikörper). This research may provide new insights into GTPase (zeige RACGAP1 Antikörper)-mediated insulin (zeige INS Antikörper) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (zeige INS Antikörper) sensitizati

  4. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (zeige INS Antikörper) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  5. Decreased miR (zeige MLXIP Antikörper)-33 levels can up-regulate IRS-2 (zeige IRS2 Antikörper) expression, which appears to compensate for the defects of the insulin (zeige INS Antikörper) signaling pathway in Irs-1 deficient mice.

  6. Acute knockdown of Insr (zeige INSR Antikörper) or both Irs1 and Irs2 (zeige IRS2 Antikörper) in adipocytes increased Adipoq (zeige ADIPOQ Antikörper) mRNA expression but reduced adiponectin (zeige ADIPOQ Antikörper) secretion.

  7. Concentration of SOCS-3 (zeige SOCS3 Antikörper) protein and coimmunoprecipitation of SOCS-3 (zeige SOCS3 Antikörper) protein with both the IR-beta subunit (zeige POLG Antikörper) as well as IRS-1 was found to be decreased by 4-HIL

  8. Authors propose that insulin (zeige INS Antikörper)/IGF-1 (zeige IGF1 Antikörper) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (zeige PROP1 Antikörper) longevity phenotype.

  9. within the hepatic compartment, mTORC1 --> S6K (zeige RPS6KB1 Antikörper) signaling regulates Akt (zeige AKT1 Antikörper) largely through IRS (zeige IARS Antikörper)-independent means with little effect upon physiologic insulin (zeige INS Antikörper) sensitivity.

  10. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (zeige FAM126A Antikörper) development and progression.

Rabbit Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (zeige FTO Antikörper) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) Interaktionspartner

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (zeige PAX6 Antikörper) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) Antikörper
  • insulin receptor substrate 1 (IRS1) Antikörper
  • insulin receptor substrate 1 (Irs1) Antikörper
  • insulin receptor substrate 1 (irs1) Antikörper
  • G972R Antikörper
  • HIRS-1 Antikörper
  • irs-1 Antikörper
  • IRS1 Antikörper
  • irs1-a Antikörper
  • IRS1IRM Antikörper
  • irsu Antikörper

Bezeichner auf Proteinebene für IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

GENE ID SPEZIES
394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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