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HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Results identified two proteins P23 (zeige CDK5R1 ELISA Kits) and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 (zeige PAK1 ELISA Kits) and Ezrin (zeige EZR ELISA Kits) in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 (zeige FLT3 ELISA Kits) receptors.
studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by dendritic cells
Studies show that HS1 functions in concert with WASp to fine-tune DC cytoarchitecture and direct cell migration.
In vivo, immunodeficient Rag2 (zeige RAG2 ELISA Kits)(-/-)gamma(c)(-/-) mice injected with HS1-silenced CLL B cells showed a decreased organ infiltration with the notable exception of the bone marrow.
Hematopoietic lineage cell specific protein 1 (zeige SP1 ELISA Kits) plays a significant functional role in platelet activation downstream of glycoprotein VI and protease-activated receptors[Hematopoietic lineage cell specific protein 1 (zeige SP1 ELISA Kits)]
data indicate that Syk (zeige SYK ELISA Kits) kinase plays an important role in the translocation of hematopoietic lineage cell-specific protein 1 (zeige SP1 ELISA Kits) (HS1) into lipid rafts
This study concludes that HS1 does not play a major role in platelet function. It is possible that a role for HS1 is masked by the presence of cortactin (zeige CTTN ELISA Kits).
tyrosine phosphorylation of HS1 occurs downstream of both PAR-1 (zeige MARK2 ELISA Kits) and PAR-4 (zeige F2RL3 ELISA Kits). HS1 phosphorylation is a Gq mediated response regulated by Src (zeige SRC ELISA Kits) kinases
Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (zeige MMP2 ELISA Kits) and MMP9 (zeige MMP9 ELISA Kits) through PI3 kinase (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 (zeige PPARG ELISA Kits) regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.
miR (zeige MLXIP ELISA Kits)-152 controls both the expression of 14-3-3beta and HLA-G (zeige HLAG ELISA Kits) and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT (zeige PARP1 ELISA Kits), APAF1 (zeige APAF1 ELISA Kits), BCL2 (zeige BCL2 ELISA Kits), BAD, BID (zeige BID ELISA Kits), MCL1 (zeige MCL1 ELISA Kits), BIRC4 (zeige XIAP ELISA Kits), BCL2L1 (zeige BCL2L1 ELISA Kits), ENDOG (zeige ENDOG ELISA Kits), YWHAB (zeige YWHAB ELISA Kits), and YWHAQ (zeige YWHAQ ELISA Kits), influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c (zeige MYO1C ELISA Kits)/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin (zeige INS ELISA Kits)-stimulated glucose uptake.
Data identified three classes of 14-3-3 (zeige YWHAQ ELISA Kits) targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB (zeige YWHAB ELISA Kits) polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
hematopoietic lineage cell-specific protein
, hematopoietic cell-specific LYN substrate 1
, hematopoietic cell-specific Lyn substrate 1
, hematopoietic lineage cell-specific protein-like
, Hematopoietic lineage cell-specific protein
, uncharacterized protein LOC563056