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Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteine (PPP1R15A)

Bezeichnung:
Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteine (PPP1R15A)
Auf www.antikoerper-online.de finden Sie aktuell 7 Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Antikörper (67) und Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 80 Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Produkte verfügbar.
Synonyme:
9630030H21, GADD34, Myd116, Peg-3, RGD1624209
alle Proteine anzeigen Gen GeneID UniProt
PPP1R15A 17872 P17564
PPP1R15A 23645 O75807
Ratte PPP1R15A PPP1R15A 171071 Q6IN02

Weitere Synonyme anzeigen

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Weitere Proteine zu Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Interaktionspartnern

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Interaktionspartner

  1. Results highlighted the essential roles played by GADD34 and CReP (zeige PPP1R15B Proteine) in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress.

  2. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 (zeige ZNF384 Proteine) is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress.

  3. Through aging or a high fat diet, insulin (zeige INS Proteine) signaling in GADD34-deficient liver converted to be down regulated compared with WT mice.

  4. Results show that GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis involved in endoplasmic reticulum stress, reactive oxygen species production and autophagy formation.

  5. avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex.

  6. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (zeige TLR4 Proteine) combined with amino acid deprivation through regulation of mTOR (zeige FRAP1 Proteine) signaling pathway in macrophages.

  7. GADD34 upregulated pro-inflammatory mediator.

  8. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2 (zeige SLC38A2 Proteine).

  9. GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene (zeige RAB1A Proteine) expression, but also reduced hepatic damage.

  10. Thus these results indicate that GADD34 appears to suppress myofibroblast differentiation through inhibiting Smad3 (zeige SMAD3 Proteine)-dependent TGFbeta (zeige TGFB1 Proteine) signal pathway and promote its apoptosis by activating caspase-3 (zeige CASP3 Proteine) pathway

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Interaktionspartner

  1. reduction of GADD34 expression significantly suppressed tumor, and resulted in decreased accumulation of MDSCs and T-cells, and inhibition of GADD34 reduced secretion of vascular epithelial growth factor alpha and transforming growth factor beta by MDSCs

  2. ANXA11 (zeige ANXA11 Proteine) rs1049550 and PPP1R15A rs557806 may improve the identification of mCRC patients sensitive to bevacizumab regimens, and further validation is required in large cohorts

  3. Data of this study strengthen the evidence of an unfolded protein response during the course of RA and provide an insight of the potential interest in GADD34 as a relevant marker for RA.

  4. The results suggest that dephosphorylation of eIF2a (zeige EIF2S1 Proteine) by GADD34 plays an important role in doxorubicin resistance of MCF-7/ADR (zeige AKR1B1 Proteine) cells.

  5. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (zeige NOX4 Proteine)) is induced downstream of ATF4 (zeige ATF4 Proteine), binds to a PP1 (zeige PPA1 Proteine)-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 (zeige PPA1 Proteine) activity to increase eIF2alpha (zeige EIF2A Proteine) phosphorylation and ATF4 (zeige ATF4 Proteine) levels.

  6. stress pathways lead to the induction of the protein GADD34, which appears to provide protection against the toxic effects of the secreted virulence factors in Pseudomonas aeruginosa infection

  7. The data highlight independent interactions of PP1 (zeige PPA1 Proteine) and eIF2alpha (zeige EIF2A Proteine) with GADD34, demonstrating that GADD34 functions as a scaffold both in vitro and in cells

  8. GADD34 may play a neuroprotective role against amyloid-beta toxicity.

  9. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (zeige IRF6 Proteine) combined with amino acid deprivation through regulation of mTOR (zeige FRAP1 Proteine) signaling pathway in macrophages.

  10. Data indicate that protein phosphatase 1 (zeige PPP1CB Proteine) subunit GADD34 directly interacts with eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha (zeige EIF2S1 Proteine)).

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Protein Überblick

Protein Überblick

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Alternative names and synonyms associated with Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A)

  • protein phosphatase 1, regulatory subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)
  • protein phosphatase 1, regulatory subunit 15A (Ppp1r15a)
  • 9630030H21 Protein
  • GADD34 Protein
  • Myd116 Protein
  • Peg-3 Protein
  • RGD1624209 Protein

Bezeichner auf Proteinebene für PPP1R15A

protein phosphatase 1, regulatory (inhibitor) subunit 15A , growth arrest and DNA damage-inducible protein GADD34 , growth arrest and DNA-damage-inducible 34 , myeloid differentiation primary response gene 116 , myeloid differentiation primary response protein MyD116 , protein phosphatase 1 regulatory subunit 15A , myeloid differentiation primary response protein MyD116 homolog , progression elevated gene 3 protein

GENE ID SPEZIES
456191 Pan troglodytes
718350 Macaca mulatta
100449481 Pongo abelii
100591446 Nomascus leucogenys
17872 Mus musculus
23645 Homo sapiens
171071 Rattus norvegicus
514688 Bos taurus
476419 Canis lupus familiaris
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