Insulin Induced Gene 1 ELISA Kits (INSIG1)
Auf finden Sie aktuell 0 Insulin Induced Gene 1 (INSIG1) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen INSIG1 Antikörper (60) und und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 73 INSIG1 Produkte verfügbar.
1810013C12Rik, CL-6, CL6, fb55a03, fi35b10, INSIG-1, wu:fb55a03, wu:fi35b10, zgc:55439
list all ELISA KIts Gen GeneID UniProt
Human INSIG1 INSIG1 3638 O15503
Maus INSIG1 INSIG1 231070 Q8BGI3
Ratte INSIG1 INSIG1 64194 Q08755

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Weitere ELISA Kits für INSIG1 Interaktionspartner

Human Insulin Induced Gene 1 (INSIG1) Interaktionspartner

  1. Our findings suggest that miR (zeige MLXIP ELISA Kits)-92a may affect cholesterol metabolism by repressing insig1, resulting in raised intracellular cholesterol levels and Golgi volume and hence enhanced protein secretion.

  2. identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

  3. Data show the essential role of PPARgamma (zeige PPARG ELISA Kits) and PPARgamma (zeige PPARG ELISA Kits) coactivator 1alpha (PGC-1alpha (zeige PPARGC1A ELISA Kits)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (zeige CD36 ELISA Kits), and leading to cholesterol depletion in hepatocytes.

  4. Our results indicated that the dysregulation of INSIG1 and SREBF1 (zeige SREBF1 ELISA Kits) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group

  5. No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (zeige INSIG2 ELISA Kits) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.

  6. From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.

  7. Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.

  8. These data suggest that p97 (zeige EIF4G2 ELISA Kits) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.

  9. INSIG1 and p41 (zeige EPB41 ELISA Kits) Arp2 (zeige ACTR2 ELISA Kits)/3 complex (p41-Arc (zeige ARPC1B ELISA Kits))reduced expression might be involved in gastric cancer development or progression

  10. INSIG-1 plays a role in regulating cholesterol concentration in human cells

Cow (Bovine) Insulin Induced Gene 1 (INSIG1) Interaktionspartner

  1. In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.

Mouse (Murine) Insulin Induced Gene 1 (INSIG1) Interaktionspartner

  1. myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection

  2. reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation

  3. we consistently observe involvement of gp78 (zeige AMFR ELISA Kits) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (zeige AMFR ELISA Kits) or TRC8 (zeige RNF139 ELISA Kits) in the robust sterol-accelerated degradation of HMG-CoA reductase (zeige HMGCR ELISA Kits).

  4. analysis of mRNA abundance and expression of SLC27A, ACC (zeige ACACA ELISA Kits), SCD (zeige SCD ELISA Kits), FADS, LPIN, INSIG, and PPARGC1 (zeige PPARGC1A ELISA Kits) gene isoforms in mouse mammary glands during the lactation cycle

  5. insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes

  6. the regulation of Insig-1 by PPARgamma (zeige PPARG ELISA Kits) agonists could in turn regulate SREBP processing and thus couple insulin (zeige INS ELISA Kits) sensitizers with the regulation of lipid homeostasis

  7. IRS2 (zeige IRS2 ELISA Kits), HK2 (zeige HK2 ELISA Kits) and INSIG1 are direct targets of TFE3 (zeige TFE3 ELISA Kits)

  8. Treatment of pregnant mice with the HMG-CoA reductase (zeige HMGCR ELISA Kits) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.

  9. Activation of CAR and PXR (zeige NR1I2 ELISA Kits) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (zeige SREBF1 ELISA Kits)).

  10. Insig-1 is a direct PPARdelta (zeige PPARD ELISA Kits) target gene in hepatocytes. PPARdelta (zeige PPARD ELISA Kits) inhibited SREBP-1 (zeige SREBF1 ELISA Kits) activation via induction of Insig-1. Overexpression of PPARdelta (zeige PPARD ELISA Kits) induced the expression of Insig-1, suppressed SREBP-1 (zeige SREBF1 ELISA Kits) activation, and ameliorated hepatic steatosis.

INSIG1 Antigen-Profil

Beschreibung des Gens

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with INSIG1

  • insulin induced gene 1 (INSIG1) Elisa Kit
  • insulin induced gene 1 (insig1) Elisa Kit
  • insulin induced gene 1 (Insig1) Elisa Kit
  • 1810013C12Rik Elisa Kit
  • CL-6 Elisa Kit
  • CL6 Elisa Kit
  • fb55a03 Elisa Kit
  • fi35b10 Elisa Kit
  • INSIG-1 Elisa Kit
  • wu:fb55a03 Elisa Kit
  • wu:fi35b10 Elisa Kit
  • zgc:55439 Elisa Kit

Bezeichner auf Proteinebene für INSIG1

insulin induced gene 1 , INSIG-1 , insulin-induced gene 1 protein , INSIG-1 membrane protein , growth response protein (CL-6) , immediate-early protein CL-6 , insulin-induced growth response protein CL-6

463839 Pan troglodytes
722766 Macaca mulatta
780766 Xenopus (Silurana) tropicalis
3638 Homo sapiens
334189 Danio rerio
446436 Xenopus laevis
420442 Gallus gallus
475554 Canis lupus familiaris
403162 Sus scrofa
511899 Bos taurus
231070 Mus musculus
64194 Rattus norvegicus
100689080 Cricetulus griseus
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