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anti-Human INSIG1 Antikörper:
anti-Mouse (Murine) INSIG1 Antikörper:
anti-Rat (Rattus) INSIG1 Antikörper:
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Human Polyclonal INSIG1 Primary Antibody für ICC, IF - ABIN258396
Engelking, Liang, Hammer, Takaishi, Kuriyama, Evers, Li, Horton, Goldstein, Brown: Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. in The Journal of clinical investigation 2005
Show all 6 Pubmed References
Human Polyclonal INSIG1 Primary Antibody für WB - ABIN4892389
Roth, Looser, Kaufmann, Blättler, Rencurel, Huang, Moore, Meyer: Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. in Molecular pharmacology 2008
INSIG1 variation may contribute to statin-induced changes in plasma triglycerides in a sex-specific manner.
argue that precursor miR (zeige MLXIP Antikörper)-122 molecules modulate polyadenylation site usage in Insig1 mRNAs, resulting in down-regulation of Insig1 protein abundance
Our findings suggest that miR (zeige MLXIP Antikörper)-92a may affect cholesterol metabolism by repressing insig1, resulting in raised intracellular cholesterol levels and Golgi volume and hence enhanced protein secretion.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
Data show the essential role of PPARgamma (zeige PPARG Antikörper) and PPARgamma (zeige PPARG Antikörper) coactivator 1alpha (PGC-1alpha (zeige PPARGC1A Antikörper)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (zeige CD36 Antikörper), and leading to cholesterol depletion in hepatocytes.
Our results indicated that the dysregulation of INSIG1 and SREBF1 (zeige SREBF1 Antikörper) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group
No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (zeige INSIG2 Antikörper) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.
From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.
Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.
These data suggest that p97 (zeige EIF4G2 Antikörper) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.
In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.
myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection
reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation
we consistently observe involvement of gp78 (zeige AMFR Antikörper) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (zeige AMFR Antikörper) or TRC8 (zeige RNF139 Antikörper) in the robust sterol-accelerated degradation of HMG-CoA reductase (zeige HMGCR Antikörper).
analysis of mRNA abundance and expression of SLC27A, ACC (zeige ACACA Antikörper), SCD (zeige SCD Antikörper), FADS, LPIN, INSIG, and PPARGC1 (zeige PPARGC1A Antikörper) gene isoforms in mouse mammary glands during the lactation cycle
insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes
the regulation of Insig-1 by PPARgamma (zeige PPARG Antikörper) agonists could in turn regulate SREBP processing and thus couple insulin (zeige INS Antikörper) sensitizers with the regulation of lipid homeostasis
IRS2 (zeige IRS2 Antikörper), HK2 (zeige HK2 Antikörper) and INSIG1 are direct targets of TFE3 (zeige TFE3 Antikörper)
Treatment of pregnant mice with the HMG-CoA reductase (zeige HMGCR Antikörper) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
Activation of CAR and PXR (zeige NR1I2 Antikörper) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (zeige SREBF1 Antikörper)).
Insig-1 is a direct PPARdelta (zeige PPARD Antikörper) target gene in hepatocytes. PPARdelta (zeige PPARD Antikörper) inhibited SREBP-1 (zeige SREBF1 Antikörper) activation via induction of Insig-1. Overexpression of PPARdelta (zeige PPARD Antikörper) induced the expression of Insig-1, suppressed SREBP-1 (zeige SREBF1 Antikörper) activation, and ameliorated hepatic steatosis.
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
insulin induced gene 1
, insulin-induced gene 1 protein
, INSIG-1 membrane protein
, growth response protein (CL-6)
, immediate-early protein CL-6
, insulin-induced growth response protein CL-6