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HERP plays an important role in the regulation of host innate immunity in response to ER stress during the infection of RNA viruses.
results indicated that low expression of miR (zeige MLXIP Proteine)-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma
Thus, our findings indicated that NQO1 (zeige NQO1 Proteine) could stabilize Herp protein expression via indirect regulation of synoviolin.
The authors found that the CREB3 (zeige CREB3 Proteine)/Herp pathway limited the increase in cytosolic Ca2 (zeige CA2 Proteine)+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis.
HERPUD1 SNPs are highly associated with polypoidal choroidal vasculopathy.
concluded that the HERPUD1-mediated cytoprotective effect against oxidative stress depends on the ITPR and Ca(2 (zeige CA2 Proteine)+) transfer from the endoplasmic reticulum to mitochondria
The results indicate that Nrf1 (zeige NFE2L1 Proteine) is a transcriptional activator of Herpud1 expression during ER stress, and they suggest Nrf1 (zeige NFE2L1 Proteine) is a key player in the regulation of the ER stress response in cells.
Herp operates as a relevant factor in the defense against glucose starvation by modulating autophagy levels.
Together with histological grade, increased co-expression of MIF (zeige AMH Proteine) and MMP9 (zeige MMP9 Proteine) in tumor might be a valuable predictor for recurrence, especially for benign meningiomas
binding of Herp to Hrd1 (zeige SYVN1 Proteine)-containing ERAD complexes positively regulates the ubiquitylation activity of these complexes, thus permitting survival of the cell during ER stress.
Herp may regulate the cell cycle and hormone secretions in mouse granulosa cells
Herp lentiviral shRNA vectors had been successfully constructed; knockdown Herp inhibited ER stress and had a different effect on inflammatory responses in RAW 264.7 macrophages depending on whether they were exposed to tunicamycin or thapsigargin
Herp localizes to the endoplasmic reticulum-derived quality control compartment (ERQC) and recruits HRD1, which targets to endoplasmic reticulum associated degradation the substrate presented by the OS-9 lectin at the ERQC.
A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE (zeige APOE Proteine) knockout mice by attenuating inflammatory responses.
Data conclude that Herpud1 regulates insulin (zeige INS Proteine) secretion via control of Nnt (zeige NNT Proteine) expression.
Derlin-1 (zeige DERL1 Proteine) deficiency is embryonic lethal, Derlin-3 (zeige DERL3 Proteine) deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
increased NADH levels resulting from ENOX2 (zeige ENOX2 Proteine) inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 (zeige ENOX2 Proteine) inhibitor-induced apoptotic cascade.
upregulation by Wnt-1 (zeige WNT1 Proteine)
Herp represents a second target, in addition to CHOP (zeige DDIT3 Proteine), that is dually regulated by both the shared and the ER stress-specific branches during unfolded protein activation
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
, homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
, homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein
, methyl methanesulfonate (MMF)-inducible fragment protein 1