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infection with New World arenaviruses JUNV and MACV, but not OW LASV, activated PKR (zeige PKLR Proteine), concomitant with elevated phosphorylation of the translation initiation factor (zeige TIF1 Proteine) alpha subunit (zeige POLG Proteine) of eukaryotic initiation factor (zeige EIF4G1 Proteine) 2
The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (zeige PKLR Proteine) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (zeige EIF2S1 Proteine).
Protein kinase (zeige CDK7 Proteine) R (PKR (zeige PKLR Proteine)) was required for induction of stress granules (SGs (zeige FBN1 Proteine)) by mumps virus (MuV) infection and regulated type III IFN (IFN-lambda1) mRNA stability.
data establish a model in which the Influenza A virus NS1 (zeige PTPN11 Proteine) N-terminal domain engages in a binding interaction to inhibit activation of PKR (zeige PKLR Proteine) and ensure efficient viral propagation and virulence
It was established in this report that interactions between PACT (zeige RBBP6 Proteine), ADAR1 (zeige ADAR Proteine) and HIV-1-encoded Tat (zeige TAT Proteine) protein diminish the activation of PKR (zeige PKLR Proteine) in response to HIV-1 infection.
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (zeige GBP1 Proteine), TLR3 (zeige TLR3 Proteine), OAS1 (zeige OAS1 Proteine), EIF2AK2, HLA-E (zeige HLAE Proteine), IFI6 (zeige IFI6 Proteine), and STAT1 (zeige STAT1 Proteine), showed higher expression in the islet core compared with the peri (zeige PLIN1 Proteine)-islet area containing the surrounding immune cells
NF90 exerts its antiviral activity by antagonizing the inhibitory role of NS1 (zeige PTPN11 Proteine) on PKR (zeige PKLR Proteine) phosphorylation
Crucially, Chlamydia trachomatis infection resulted in robust IRE1alpha (zeige ERN1 Proteine) RNAse activity that was dependent on TLR4 (zeige TLR4 Proteine) signalling and inhibition of IRE1alpha (zeige ERN1 Proteine) RNAse activity prevented PKR (zeige PKLR Proteine) activation.
the expression of a Tat (zeige TAT Proteine) construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR (zeige PKLR Proteine), favored neither parasite growth nor IL-10 (zeige IL10 Proteine) expression in infected macrophages.
This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (zeige NIPBL Proteine) and HDAC8 (zeige HDAC8 Proteine) mutations and PKR (zeige PKLR Proteine) activation.
PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress.
We therefore concluded that in osteoblasts, P. gingivalis activated PKR, which in turn increased NLRP3 (zeige NLRP3 Proteine) expression by activating NF-kappaB (zeige NFKB1 Proteine). Our results suggest that PKR modulates inflammation by regulating the expression of the NLRP3 (zeige NLRP3 Proteine) inflammasome through the NF-kappaB (zeige NFKB1 Proteine) pathway in periodontal diseases.
identify iNOS (zeige NOS2 Proteine)/NO as an integral component of IFN-beta (zeige IFNB1 Proteine) production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3 (zeige TLR3 Proteine)/Trif (zeige RNF138 Proteine) and PKR
The data predicts that PKR diminishes inflammasome activity by controlling protein translation to repress the induction of factors that are critical for the activity of the cryopyrin (zeige NLRP3 Proteine) inflammasome.
This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (zeige NIPBL Proteine) and HDAC8 (zeige HDAC8 Proteine) mutations and PKR activation.
Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.
results show that ceramide acts at two distinct levels of the insulin (zeige INS Proteine) signaling pathway (IRS1 (zeige IRS1 Proteine) and Akt (zeige AKT1 Proteine)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (zeige INS Proteine) resistance in muscle cells.
Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (zeige CDK7 Proteine) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (zeige CDK7 Proteine) R) in development of postnatal anterior pituitary tissue.
Data indicate increasing expression of PKR during TNF-a (zeige TNF Proteine)-induced osteoclast formation. Its inhibition prevents TNF-a (zeige TNF Proteine)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.
The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
double-stranded RNA-activated protein kinase
, interferon-induced, double-stranded RNA-activated protein kinase
, p68 kinase
, P1/eIF-2A protein kinase
, interferon-inducible RNA-dependent protein kinase
, IFN-stimulated dsRNA-activated eIF2-alpha kinase 2
, double-stranded RNA activated protein kinase
, eukaryotic translation initiation factor 2-alpha kinase 2
, double stranded RNA activated protein kinase
, eIF-2A protein kinase 2
, interferon-inducible elF2alpha kinase
, protein kinase, interferon-inducible double stranded RNA dependent
, tyrosine-protein kinase EIF2AK2
, IFN- type I-induced and dsRNA-activated kinase
, IFN-induced and double-stranded RNA-activated kinase
, T-cell viral integration site
, dsRNA-activated kinase
, eIF-2 alpha
, eukaryotic translation initiation factor 2 alpha kinase 2
, protein kinase RNA-activated
, protein kinase, interferon inducible double stranded RNA dependent
, serine/threonine-protein kinase TIK
, Protein kinase, interferon-inducible double stranded RNA dependent