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In summary, our study revealed a negative regulation of the UPR transducer ATF6 through post-translational SUMOylation. The information from this study will not only increase our understanding of the fine-tuning regulation of the UPR signaling but will also be informative to the modulation of the UPR for therapeutic benefits.
Low ATF6 expression is associated with cancer.
Activating transcription factor 6 (ATF6alpha) pathway and ER-associated protein degradation (ERAD) are elevated in salivary glands of Sjogren's syndrome patients (SS).
A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta (zeige CEBPB Proteine) is required for the IFN-gamma-induced (zeige SAMHD1 Proteine) expression of DAPK1 (zeige DAPK1 Proteine) IFN-gamma-induced (zeige SAMHD1 Proteine) proteolytic processing of ATF6 and phosphorylation of C/EBP-beta (zeige CEBPB Proteine) are obligatory for the formation of this transcriptional complex
Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (zeige DAPK1 Proteine)) by western blotting; the transcription of DAPK1 (zeige DAPK1 Proteine) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (zeige ATG9A Proteine) by immunofluorescence.
Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
We found that HCS (zeige HLCS Proteine) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (zeige INS Proteine) signaling through p85-XBP1 (zeige XBP1 Proteine) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
ATF6 is essential for ER stress-mediated SESN2 (zeige SESN2 Proteine) induction.
Forced activation of the ATF6 UPR branch reduced infarct volume and improved functional outcome at 24 h after stroke
However, depletion of XBP1 (zeige XBP1 Proteine) and ATF6, alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.
Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.
we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (zeige INS Proteine)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (zeige INS Proteine)-resistant mice.
The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.
ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.
ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 and enhancing Runx2-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH and PTHrP signaling.
Data show that EIF2AK3/PERK (zeige EIF2AK3 Proteine)-mediated downregulation of miR (zeige MLXIP Proteine)-424(322)-503 cluster regulates optimal activation of IRE1 (zeige ERN1 Proteine) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.
Exposure of endothelial cells to VEGF (zeige VEGFA Proteine), high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha