Zinc Finger Protein 281 Proteine (ZNF281)

Bezeichnung:
Zinc Finger Protein 281 Proteine (ZNF281)
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Synonyme:
ZBP-99, Znf281, ZNP-99
alle Proteine anzeigen Gen GeneID UniProt
ZNF281 23528 Q9Y2X9
Maus ZNF281 ZNF281 226442  

Weitere Synonyme anzeigen

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Weitere Proteine zu Zinc Finger Protein 281 Interaktionspartnern

Human Zinc Finger Protein 281 (ZNF281) Interaktionspartner

  1. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms

  2. High ZNF281 expression is associated with colon and breast cancer.

Mouse (Murine) Zinc Finger Protein 281 (ZNF281) Interaktionspartner

  1. AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron.

  2. involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms

  3. Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency.

  4. Zpf281 mediates Nanog autorepression through recruitment of the NuRD complex and hibits somatic cell reprogramming.

  5. Data demonstrated that Zfp281 is required for Nanog (zeige NANOG Proteine) binding to its own promoter, suggesting that Nanog (zeige NANOG Proteine)-associated repressive complex(es) involving Zfp281 may fine-tune Nanog (zeige NANOG Proteine) expression for pluripotency of ESCs (zeige NR2E3 Proteine).

  6. Zfp281 plays bifunctional roles in regulating gene expression within the network.

Zinc Finger Protein 281 (ZNF281) Protein Überblick

Protein Überblick

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes.

Alternative names and synonyms associated with Zinc Finger Protein 281 (ZNF281)

  • zinc finger protein 281 (ZNF281)
  • zinc finger protein 281 (znf281)
  • zinc finger protein 281 (Zfp281)
  • ZBP-99 Protein
  • Znf281 Protein
  • ZNP-99 Protein

Bezeichner auf Proteinebene für ZNF281

zinc finger protein 281 , GC-box-binding zinc finger protein 1 , ZNP-99 transcription factor , transcription factor ZBP-99 , zinc finger DNA-binding protein 99

GENE ID SPEZIES
469632 Pan troglodytes
709466 Macaca mulatta
733827 Xenopus (Silurana) tropicalis
101749232 Gallus gallus
23528 Homo sapiens
490250 Canis lupus familiaris
226442 Mus musculus
532401 Bos taurus
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