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involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
High ZNF281 expression is associated with colon and breast cancer.
AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron.
Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency.
Zpf281 mediates Nanog autorepression through recruitment of the NuRD complex and hibits somatic cell reprogramming.
Data demonstrated that Zfp281 is required for Nanog (zeige NANOG Proteine) binding to its own promoter, suggesting that Nanog (zeige NANOG Proteine)-associated repressive complex(es) involving Zfp281 may fine-tune Nanog (zeige NANOG Proteine) expression for pluripotency of ESCs (zeige NR2E3 Proteine).
Zfp281 plays bifunctional roles in regulating gene expression within the network.
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes.
zinc finger protein 281
, GC-box-binding zinc finger protein 1
, ZNP-99 transcription factor
, transcription factor ZBP-99
, zinc finger DNA-binding protein 99