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The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
SLBP (zeige SLBP Proteine) is a potentially important cellular regulator of HIV-1, thereby establishing a link between histone metabolism, inflammation, and HIV-1 infection
showed that inhibiting the SLBP (zeige SLBP Proteine) mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP (zeige SLBP Proteine) may be mediated via epigenetic mechanisms
Cyclin F (zeige CCNF Proteine)-mediated degradation of SLBP (zeige SLBP Proteine) limits H2A.X (zeige H2AFX Proteine) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
CRL4(WDR23 (zeige DCAF11 Proteine)) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23 (zeige DCAF11 Proteine)) binds and ubiquitylates SLBP (zeige SLBP Proteine) in vitro and in vivo, and this modification activates SLBP (zeige SLBP Proteine) function in histone mRNA 3' end processing without affecting its protein levels.
FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (zeige SLBP Proteine).
CRL4-DCAF11 (zeige DCAF11 Proteine) mediates the degradation of SLBP (zeige SLBP Proteine) at the end of S phase and this degradation is essential for the viability of cells.
The authors propose a structural organization where the AMSH (zeige STAMBP Proteine)-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH (zeige STAMBP Proteine) prior to polyubiquitin (zeige UBB Proteine) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 (zeige HMGCR Proteine) domain-containing proteins, Alix (zeige PDCD6IP Proteine) and Brox, binds CHMP4B (zeige CHMP4A Proteine) but not STAM2, despite their high structural similarity
arsenic, a carcinogenic metal, decreases cellular levels of SLBP (zeige SLBP Proteine) by inducing its proteasomal degradation and inhibiting SLBP (zeige SLBP Proteine) transcription via epigenetic mechanisms
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM (zeige STAM Proteine) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 (zeige GRB2 Proteine) retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein (zeige KLK7 Proteine) binding
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, signal transducing adapter molecule 2
, Hrs binding protein
, hrs-binding protein
, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like