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MON1/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-mediated Rab7 activation was indispensable for vacuolar trafficking of tapetum degradation-related cysteine proteases.
Data provide new insight into how disease-associated alterations in Rab7 protein disrupt cellular function in vertebrate sensory neurons. Moreover, findings suggest that defects in axon development may be a previously unrecognized component of Charcot-Marie-Tooth2b disease.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (zeige Rab5c Antikörper) (early endosomes), Rab11a (zeige RAB11A Antikörper) (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development.
WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
Vps34 (zeige PIK3C3 Antikörper) has a previously unknown role in regulating Rab7 activity and late endosomal trafficking.
Rab7 accumulated in GCase (zeige GBA Antikörper) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA Antikörper) can reverse ALR (zeige GFER Antikörper) impairment, we anticipate that strategies to restore GCase (zeige GBA Antikörper) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA Antikörper) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
The up-regulation of Rab11 (zeige RAB11A Antikörper), Rab7, or RILP (zeige RILP Antikörper), but not its truncated form RILP (zeige RILP Antikörper)-C33 (zeige CD82 Antikörper), rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 (zeige RAB11A Antikörper) or Rab7 impaired LAMP2A trafficking.
The inhibition of autophagosome-lysosome fusion induced by SapM is dependent on the interaction between SapM and Rab7.
Prion (zeige PRNP Antikörper) infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells.
photoreceptor outer segments vesicles engulfed through Lyar-dependent pathway were targeted to phagosomes and colocalized with phagosome marker Rab7
B cell Rab7 mediates induction of activation-induced cytidine deaminase (zeige AICDA Antikörper) expression and class-switching in T-dependent and T-independent antibody responses.
CREG1 (zeige CREG1 Antikörper) deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1 (zeige CREG1 Antikörper)-induced cardiomyocyte autophagy.
Tropheryma whipplei blocks the switch from Rab5 (zeige RAB5A Antikörper) to Rab7.
WDR91 serves as a Rab7 (zeige RAB7B Antikörper) effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
The Vici syndrome protein EPG5 (zeige EPG5 Antikörper) is a Rab7 (zeige RAB7B Antikörper) effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes.
up-regulation of RAB7A reported in Alzheimer's disease, could contribute to the extracellular accumulation of pathological TAU
Rab7 (zeige RAB7B Antikörper) accumulated in GCase (zeige GBA Antikörper) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA Antikörper) can reverse ALR (zeige GFER Antikörper) impairment, we anticipate that strategies to restore GCase (zeige GBA Antikörper) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA Antikörper) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
Rab7a depletion decreases the amount of active Rac1 but not its abundance and reduces the number of cells with vimentin (zeige VIM Antikörper) filaments facing the wound, indicating that Rab7a has a role in the orientation of vimentin (zeige VIM Antikörper) filaments during migration
The study highlighted the importance of a phosphorylation/dephosphorylation switch in controlling timely Rab7 (zeige RAB7B Antikörper) localization and activity on endosomes.
show that the maturation of Mtb (zeige NCAPG2 Antikörper)-containing autophagosomes into autolysosomes required recruitment of the late endosome marker RAB7 (zeige RAB7B Antikörper), forming the intermediate compartment amphisomes
We validated ANKRD13A as a novel constituent of BCR (zeige BCR Antikörper) signalosome and showed that BCR (zeige BCR Antikörper)-induced phosphorylation of RAB7A at S72 regulates its association with its effector proteins and with endo-lysosomal compartments.
Hepatitis B virus can regulate its own secretion through an activation of the endo-lysosomal and autophagic pathway mediated by Rab7 (zeige RAB7B Antikörper) activation.
provides molecular insights into the essential role of Vps26 (zeige VPS26A Antikörper) and Vps35 (zeige vps35 Antikörper) in Rab7 (zeige RAB7B Antikörper)-mediated recruitment of the core retromer complex
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
ras-related protein Rab-7
, ras-related protein Rab-7a
, RAB7A, member RAS oncogene family
, rab7A protein
, ras-related protein rab-7a
, RAB7, member RAS oncogene family
, dystrophin-associated glycoprotein 1
, Ras-associated protein RAB7
, GTP-binding protein (rab7)
, ras-related protein BRL-RAS
, ras-related protein p23