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this study reveals the function of IL-15 (zeige IL15 Proteine) in astrocyte survival via Akt (zeige AKT1 Proteine) phosphorylation in response to OGD (zeige FGFR1 Proteine)-induced damage.
This study demonstrates the neuroprotective effect of TSG (zeige TWSG1 Proteine) on APP (zeige APP Proteine) expression, suggesting that TSG (zeige TWSG1 Proteine) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (zeige INS Proteine) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt (zeige AKT1 Proteine)) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (zeige SETDB1 Proteine) regulates PTEN/AKT (zeige AKT1 Proteine)/FOXO1 (zeige FOXO1 Proteine) pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (zeige AKT1 Proteine)-FoxO1 (zeige FOXO1 Proteine) but not p38 MAPK (zeige MAPK14 Proteine) or Erk1/2 MAPK (zeige MAPK1 Proteine) pathways.
Ablation of Cyclophilin D (zeige PPIF Proteine) Results in an Activation of FAK (zeige PTK2 Proteine), Akt (zeige AKT1 Proteine), and ERK (zeige EPHB2 Proteine) Pathways in the Mouse Heart.(
These results reveal a novel signaling network, the Sema4D (zeige SEMA4D Proteine)-RhoA (zeige RHOA Proteine)-Akt (zeige AKT1 Proteine) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
This is perhaps the first report demonstrating that AKT1 signaling prevailing in the mesenchymal stem cells regulates hematopoietic stem cell functionality through various intercellular communication mechanisms.
L. donovani triggered AKT (zeige AKT1 Proteine) activation to regulate GSK-3beta/beta-catenin (zeige CTNNB1 Proteine)/FOXO-1 (zeige FOXO1 Proteine) axis.
In summary, our data suggested that PYK2 via S6K1 (zeige RPS6KB1 Proteine) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (zeige RPS6KB1 Proteine) may potentially serve as therapeutic targets for PCa (zeige FLVCR1 Proteine) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (zeige CTNNB1 Proteine) in the crosstalk between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Wnt (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+) signaling pathways upon Wnt3a (zeige WNT3A Proteine) stimulation in differentiating hNPCs.
STIM1 (zeige STIM1 Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (zeige PTPRB Proteine) and VE-cadherin (zeige CDH5 Proteine) and hence increase endothelial permeability.
Ascites and CCL18 (zeige CCL18 Proteine) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (zeige PIK3CA Proteine)-Akt/PKB (zeige AKT1 Proteine) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (zeige EGFR Proteine) and IL8 (zeige IL8 Proteine) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (zeige CCR7 Proteine) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (zeige LPXN Proteine).
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta