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mTORC2 (zeige CRTC2 Proteine) complex is responsible for phosphorylating Akt (zeige AKT1 Proteine) at S(473).
FHL2 (zeige FHL2 Proteine) facilitates ovarian granulosa cell tumor progression via controlling AKT1 (zeige AKT1 Proteine) transcription.
Omentin (zeige ITLN1 Proteine) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt (zeige AKT1 Proteine)/NOS3 (zeige NOS3 Proteine)-dependent mechanism.
AIM2 (zeige AIM2 Proteine) contributes to the maintenance of intestinal integrity via Akt (zeige AKT1 Proteine) and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (zeige ICAM1 Proteine) resulted in activation of Akt (zeige AKT1 Proteine) and beta-catenin (zeige CTNNB1 Proteine) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (zeige INS Proteine) dependent Akt (zeige AKT1 Proteine) phosphorylation and subsequently activates FoxO1 (zeige FOXO1 Proteine) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (zeige PEPCK Proteine) and G6pase (zeige G6PC Proteine). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (zeige AKT1 Proteine) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (zeige AKT1 Proteine) in heart.
High Akt1 (zeige AKT1 Proteine) expression is associated with hepatocarcinogenesis.
Lineage-tracing of monocyte populations suggests that Pyk2 promotes apoptosis in BM monocytes, thereby acting as an important homeostatic regulator of turnover in these short-lived, innate immune cells.
Pyk2 selectively contributes to the coordination of phagocytosis-promoting signals downstream of CR3 (zeige ITGAM Proteine), but is dispensable for FcgammaR-mediated phagocytosis
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (zeige CTNNB1 Proteine) in the crosstalk between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Wnt (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+) signaling pathways upon Wnt3a (zeige WNT3A Proteine) stimulation in differentiating hNPCs.
STIM1 (zeige STIM1 Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (zeige PTPRB Proteine) and VE-cadherin (zeige CDH5 Proteine) and hence increase endothelial permeability.
Ascites and CCL18 (zeige CCL18 Proteine) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (zeige PIK3CA Proteine)-Akt/PKB (zeige AKT1 Proteine) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (zeige EGFR Proteine) and IL8 (zeige IL8 Proteine) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (zeige CCR7 Proteine) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (zeige LPXN Proteine).
Src (zeige SRC Proteine) has a role in priming Pyk2 (but not FAK (zeige PTK2 Proteine)) phosphorylation and subsequent activation downstream of integrins
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta