anti-Ratte (Rattus) PTK2B Antikörper für Intracellular Staining

Recommended PTK2B Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antikörper
  • Akt
  • PKB
  • Rac
  • PKB/Akt
  • PKBalpha
  • CADTK
  • CAKB
  • FADK2
  • FAK2
  • PTK
  • PYK2
  • RAFTK
  • CAKbeta
  • Pyk2
  • E430023O05Rik
  • Raftk
  • v-akt murine thymoma viral oncogene homolog 1
  • thymoma viral proto-oncogene 1
  • protein tyrosine kinase 2 beta
  • PTK2 protein tyrosine kinase 2 beta
  • PTK2B protein tyrosine kinase 2 beta
  • Akt1
  • PTK2B
  • Ptk2b
Epitop
pTyr402
52
20
15
15
14
13
13
10
8
7
7
7
5
5
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
251
165
146
12
11
9
7
7
6
5
2
1
1
1
Wirt
Maus
212
40
3
Klonalität
Monoklonal
Konjugat
Dieser PTK2B Antikörper ist konjugiert mit Alexa Fluor 647
6
6
5
3
3
3
3
3
3
3
3
3
3
3
3
2
2
Applikation
Intracellular Staining (ICS)
199
104
94
57
39
25
21
6
3
2
1
1
1
1
Optionen
Hersteller
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Produktnummer ABIN1177155
252,46 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1177156 ICS PE Mouse IgG2b, kappa pTyr402 Anmelden zum Anzeigen L68-1256-272 6

anti-PTK2B Antikörper für Intracellular Staining mit den meisten Publikationen

Ähnliche anti-PTK2B Antikörper

Applikation / Reaktivität Human Maus Ratte (Rattus)
Immunofluorescence (fixed cells) (IF/ICC) 2 Antikörper 2 Antikörper 2 Antikörper
Western Blotting (WB) 194 Antikörper 112 Antikörper 94 Antikörper
Proximity Ligation Assay (PLA) 1 Antikörper
Intracellular Staining (ICS) 2 Antikörper 2 Antikörper 2 Antikörper
Immunoprecipitation (IP) 19 Antikörper 6 Antikörper 10 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 56 Antikörper 39 Antikörper 33 Antikörper
Immunohistochemistry (IHC) 102 Antikörper 67 Antikörper 56 Antikörper

General

Antigen PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antikörper
Epitop pTyr402
(52), (20), (15), (15), (14), (13), (13), (10), (8), (7), (7), (7), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(251), (165), (146), (12), (11), (9), (7), (7), (6), (5), (2), (1), (1), (1)
Wirt Maus
(212), (40), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser PTK2B Antikörper ist konjugiert mit Alexa Fluor 647
(6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Applikation Intracellular Staining (ICS)
(199), (104), (94), (57), (39), (25), (21), (6), (3), (2), (1), (1), (1), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PTK2B Antikörper

Target Details PTK2B Anwendungsinformationen Handhabung ProductDetails: References for anti-PTK2B antibody (ABIN1177155) Bilder
Marke BD Phosflow™
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Phosphorylated Human Pyk2 Peptide
Klon L68-1256-272
Isotyp IgG2b, kappa

Target Details PTK2B

Produktdetails anti-PTK2B Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-PTK2B antibody (ABIN1177155) Bilder zurück nach oben
Antigen
Andere Bezeichnung Pyk2 (PTK2B Antibody Abstract)
Hintergrund Proline-rich tyrosine kinase 2 (Pyk2) is a member of the FAK subfamily of tyrosine protein kinases. Pyk2 responds to a wide variety of inflammatory and stress stimuli, such as cytokines, ligation of integrins or antigen receptors, mechanical strain, and cellular depolarization. A common characteristic of most Pyk2 stimuli is an increase in cytosolic free calcium. Pyk2 is involved in signaling pathways that regulate vital cellular functions in hematopoietic, epithelial, neuronal, endothelial, and other cell types. Activation of Pyk2 initiates its autophosphorylation at tyrosine 402 (Y402), followed by Src-mediated phosphorylation of other Pyk2 tyrosine sites, which enhances its activity and leads to downstream signal transduction through the MAPK and JNK pathways. The L68-1256.272 monoclonal antibody recognizes the phosphorylated Y402 of activated Pyk2.
Synonyms: Protein tyrosine kinase 2beta, FAK2, FADK 2, CAKbeta, CADTK, RAFTK
Pathways EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation

Anwendungsinformationen

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Handhabung ProductDetails: References for anti-PTK2B antibody (ABIN1177155) Bilder zurück nach oben
Applikationshinweise Either BD Cytofix™ fixation buffer or BD™ Phosflow Fix Buffer I may be used for cell fixation. Any of the three BD™ Phosflow permeabilization buffers may be used.
Probenmenge 20 μL
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Anwendungsinformationen ProductDetails: References for anti-PTK2B antibody (ABIN1177155) Bilder zurück nach oben
Format Liquid
Buffer Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

ProductDetails: References for anti-PTK2B antibody (ABIN1177155)

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Anand, Cucchiarini, Terwilliger, Ganju: "The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5636-44, 2008

Faure, Corvol, Toutant, Valjent, Hvalby, Jensen, El Messari, Corsi, Kadaré, Girault: "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons." in: Journal of cell science, Vol. 120, Issue Pt 17, pp. 3034-44, 2007

Gluck: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, 2004

Orr, Murphy-Ullrich: "Regulation of endothelial cell function BY FAK and PYK2." in: Frontiers in bioscience : a journal and virtual library, Vol. 9, pp. 1254-66, 2004

Park, Avraham, Avraham: "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33315-22, 2004

Avraham, Park, Schinkmann, Avraham: "RAFTK/Pyk2-mediated cellular signalling." in: Cellular signalling, Vol. 12, Issue 3, pp. 123-33, 2000