anti-Human PTK2B Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended PTK2B Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antikörper
  • Akt
  • PKB
  • Rac
  • PKB/Akt
  • PKBalpha
  • CADTK
  • CAKB
  • FADK2
  • FAK2
  • PTK
  • PYK2
  • RAFTK
  • CAKbeta
  • Pyk2
  • E430023O05Rik
  • Raftk
  • v-akt murine thymoma viral oncogene homolog 1
  • thymoma viral proto-oncogene 1
  • protein tyrosine kinase 2 beta
  • PTK2 protein tyrosine kinase 2 beta
  • PTK2B protein tyrosine kinase 2 beta
  • Akt1
  • PTK2B
  • Ptk2b
Epitop
AA 370-420, pTyr402
53
20
15
14
14
13
13
10
8
8
7
7
5
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
254
166
146
12
11
9
7
7
6
5
2
1
1
1
Wirt
Kaninchen
213
42
3
Klonalität
Polyklonal
Konjugat
Dieser PTK2B Antikörper ist unkonjugiert
6
6
5
4
3
3
3
3
3
3
3
3
3
3
3
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
201
105
95
56
38
25
21
6
3
2
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN745763
$ 329.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
13.671394 ABIN4348749 ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 1
13.671394 ABIN239840 IHC (p) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal
13.671394 ABIN5611627 EIA IHC (p) Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal
13.671394 ABIN271797 IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal
13.671394 ABIN745778 IF (p) IHC (p) WB Rabbit IgG pTyr881 Anmelden zum Anzeigen Polyclonal
13.671394 ABIN4348747 ELISA IHC IHC (p) WB Mouse IgG2a Anmelden zum Anzeigen 5E2D5
13.671394 ABIN4348748 ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN257536 ICC IF IHC (p) IHC WB Rabbit pTyr402 Anmelden zum Anzeigen Polyclonal 1
1 ABIN197440 IF IHC (p) WB Rabbit Tyr402 Anmelden zum Anzeigen Polyclonal 2
1 ABIN196952 IF IHC (p) WB Rabbit pTyr402 Anmelden zum Anzeigen Polyclonal 5
1 ABIN372323 IHC (p) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal
1 ABIN745118 IF (p) IHC (p) WB Rabbit IgG AA 20-70 Anmelden zum Anzeigen Polyclonal 1
1 ABIN1500493 IHC (p) WB Rabbit IgG AA 812-861 Anmelden zum Anzeigen Polyclonal
1 ABIN1103847 IHC (p) IP ELISA WB Mouse IgG1 AA 5-416 Anmelden zum Anzeigen
1 ABIN1107180 EIA IHC (p) WB Mouse IgG2a Anmelden zum Anzeigen 5E2D5 2
1 ABIN271907 IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal
1 ABIN574019 ICC IF IHC (p) ELISA WB Mouse IgG2a AA 815-997 Anmelden zum Anzeigen 5E2D5
1 ABIN2888605 IHC (p) ELISA WB Rabbit IgG AA 847-896 Anmelden zum Anzeigen Polyclonal
1 ABIN2879114 IHC (p) ELISA Rabbit IgG AA 369-418 Anmelden zum Anzeigen Polyclonal
1 ABIN658200 IHC (p) WB Rabbit Ig AA 672-701, Center Anmelden zum Anzeigen Polyclonal

General

Antigen PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Antikörper
Epitop AA 370-420, pTyr402
(53), (20), (15), (14), (14), (13), (13), (10), (8), (8), (7), (7), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(254), (166), (146), (12), (11), (9), (7), (7), (6), (5), (2), (1), (1), (1)
Wirt Kaninchen
(213), (42), (3)
Klonalität
Polyklonal
Konjugat Dieser PTK2B Antikörper ist unkonjugiert
(6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(201), (105), (95), (56), (38), (25), (21), (6), (3), (2), (2), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PTK2B Antikörper

Target Details PTK2B Anwendungsinformationen Handhabung Referenzen für anti-PTK2B Antikörper (ABIN745763) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human Pyk2/PTK2B around the phosphorylation site of Tyr402
Isotyp IgG

Target Details PTK2B

Produktdetails anti-PTK2B Antikörper Anwendungsinformationen Handhabung Referenzen für anti-PTK2B Antikörper (ABIN745763) Bilder zurück nach oben
Antigen
Andere Bezeichnung Pyk2 (PTK2B Antibody Abstract)
Hintergrund

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels.

Synonyms: Protein-tyrosine kinase 2-beta, Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK, PTK2B, FAK2, PYK2

Gen-ID 2185
UniProt Q14289
Pathways EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling

Anwendungsinformationen

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Handhabung Referenzen für anti-PTK2B Antikörper (ABIN745763) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Anwendungsinformationen Referenzen für anti-PTK2B Antikörper (ABIN745763) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-PTK2B Antikörper (ABIN745763)

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: "Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis." in: Bone, Vol. 74C, pp. 58-68, 2015

Bilder

Produktdetails anti-PTK2B Antikörper Target Details PTK2B Anwendungsinformationen Handhabung Referenzen für anti-PTK2B Antikörper (ABIN745763) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 370-420), (pTyr402) antibody (ABIN745763) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-Pyk2/...
Immunohistochemistry (IHC) image for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 370-420), (pTyr402) antibody (ABIN745763) Formalin-fixed and paraffin embedded rat spleen labeled with Rabbit Anti phospho-Pyk2...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 370-420), (pTyr402) antibody (ABIN745763) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 370-420), (pTyr402) antibody (ABIN745763) Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling i...