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Results suggest that zebrafish may be used as a model organism to address the function of PLCepsilon 1 during the development of organs.
rs10882379 and rs829232 SNPs in the PLCE1 gene may contribute to the esophageal squamous cell carcinoma (ESCC) susceptibility in Chinese Han population. Also the gene-gene and gene-environment interactions play a certain crucial role in the ESCC progression.
No association between PLCE1 genotype and early viremia level in dengue patients.
PLCE1 single-nucleotide polymorphism is associated with migraine.
PLCE1 expression was found in the invasive carcinoma but not in the carcinoma in situ samples. Snail (zeige SNAI1 ELISA Kits) expression in the human ESCC samples significantly correlated with the PLCE1 protein level, and expression of Snail (zeige SNAI1 ELISA Kits) target genes in human esophageal cancer samples were also correlated with the PLCE1 abundance.
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
High PLC (zeige HSPG2 ELISA Kits) epsilon expression is associated with breast cancer.
The mRNA expressions of PPP3CB (zeige PPP3CB ELISA Kits) and MEF2C (zeige MEF2C ELISA Kits) were significantly up-regulated, and CAMK1 (zeige CAMK1 ELISA Kits) and PPP3R1 (zeige PPP3R1 ELISA Kits) were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB (zeige PPP3CB ELISA Kits), MEF2C (zeige MEF2C ELISA Kits) and PLCE1 compared to aortic valve disease patients
Two novel putatively deleterious PLCE1 variants were identified in children with steroid-resistant nephrotic syndrome.
PLC (zeige HSPG2 ELISA Kits)-epsilon is a novel regulator of endothelial cell inflammation and vascular endothelial permeability.
Taken together, our data highlight the pivotal role of miR (zeige MLXIP ELISA Kits)-1976 in the progression of NSCLC. Thus, miR (zeige MLXIP ELISA Kits)-1976 may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (zeige CNR1 ELISA Kits) receptors. Among the six isoforms of phospholipase C (PLC (zeige PLC ELISA Kits); PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta (zeige PLCz1 ELISA Kits), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (zeige DHDDS ELISA Kits)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac (zeige RAPGEF3 ELISA Kits), enhances 2-AG-mediated synaptic depress...
study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury
PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis.
Thrombin (zeige F2 ELISA Kits) promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C ELISA Kits) and Ras-associating domains of phospholipase C epsilon.
PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells.
a new pathway for TRPC6 (zeige TRPC6 ELISA Kits) activation by Phospholipase C epsilon
findings reveal a pathway initiated by GPCR (zeige GPBAR1 ELISA Kits) agonist-induced RhoA (zeige RHOA ELISA Kits) activation, in which PLCepsilon signals to PKD1 (zeige PKD1 ELISA Kits)-mediated phosphorylation of cytoskeletal proteins
Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF (zeige PDGFA ELISA Kits).
PLCepsilon links G protein-coupled receptors (GPCR (zeige GPBAR1 ELISA Kits)) to sustained PKD (zeige PRKD1 ELISA Kits) activation, providing a means for GPCR (zeige GPBAR1 ELISA Kits) ligands that couple to RhoA (zeige RHOA ELISA Kits) to induce NF-kappaB (zeige NFKB1 ELISA Kits) signaling and promote neuroinflammation.
These results reveal a crucial role of PLCepsilon in the development of skin inflammation and suggest a mechanism in which PLCepsilon induces the production of cytokines including IL-23 (zeige IL23A ELISA Kits) from keratinocytes, leading to the activation of IL-22 (zeige IL22 ELISA Kits)-producing T cells.
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome\; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
phospholipase C, epsilon 1
, pancreas-enriched phospholipase C
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
, phosphoinositide phospholipase C-epsilon-1
, phosphoinositide-specific phospholipase C epsilon-1
, phospholipase C-epsilon-1
, phospholipase C epsilon