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Fibroblast growth factor signaling requires Xmig6 for muscle differentiation in Xenopus embryos. Fibroblast growth factor signaling may involve XGPCR4 (zeige GPR84 Antikörper) in gastrulation.
ectopic expression of Gene 33 triggers DNA damage response in an ATM serine/threonine kinase (ATM)-dependent fashion and through pathways dependent or not dependent on ABL proto-oncogene 1 non-receptor tyrosine kinase (c-Abl).
our data suggest that dormant cancer cells with a high MIG6 expression level might be one of the causes of EGFR (zeige EGFR Antikörper)-TKI resistance in EGFR (zeige EGFR Antikörper) mutant lung cancer cells.
Down-regulation of Mig-6 induces Cyclin D1 (zeige CCND1 Antikörper) expression and activates the MAPK-ERK (zeige MAPK1 Antikörper) signaling pathway. Our study shows that the expression of Mig-6 protein is low in hepatocellular carcinoma, which predicts a poor prognosis.
PIPKIgammai5, NEDD4-1 (zeige NEDD4 Antikörper), and Mig6 form a novel molecular nexus that controls EGFR (zeige EGFR Antikörper) activation and downstream signaling.
Low MIG6 expression is associated with lung cancer.
MIG6 down regulation may promote the migration and invasiveness of MEK (zeige MAP2K1 Antikörper) inhibited mutant NRAS (zeige NRAS Antikörper) melanoma.
MIG6 is a potent tumor suppressor for mutant EGFR (zeige EGFR Antikörper)-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR (zeige EGFR Antikörper) can partially circumvent this tumor suppressor in human lung adenocarcinoma.
Crystal structures of human EGFR (zeige EGFR Antikörper)-Mig6 complexes show how Mig6 rearranges after phosphorylation by EGFR (zeige EGFR Antikörper) to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation.
MIG-6 efficiently reduces cellular transformation driven by oncogenic BRAF (zeige BRAF Antikörper) by orchestrating a negative feedback circuit directed towards the EGFR (zeige EGFR Antikörper).
study provides a new molecular mechanism to regulate EGFR (zeige EGFR Antikörper) signaling through modulation of MIG6 by DNAJB1 (zeige DNAJB1 Antikörper) as a negative regulator.
Studies indicate that progesterone receptor (zeige PGR Antikörper) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (zeige CXCL9 Antikörper)-6over) phosphatase and tensin homolog (zeige PTEN Antikörper) protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (zeige MAPK1/3 Antikörper) and its target genes.
mouse Mig-6 ablation in the liver results in multiple metabolic phenotypes such as fatty liver, fasting hyperglycemia, and hypercholesterolemia but in lower bodyweight and improved insulin (zeige INS Antikörper) sensitivity.
Liver-specific ablation of Mig-6 caused hyperglycemia by hepatic insulin (zeige INS Antikörper) resistance.
This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2 (zeige CITED2 Antikörper), the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis
Mig-6 plays a critical role in the development of atherosclerosis.
our findings suggest that Mig-6 regulates ERK1/2 (zeige MAPK1/3 Antikörper) phosphorylation and that it is crucial for progression of PTEN (zeige PTEN Antikörper)-mutant endometrial cancers, providing a mechanistic rationale for the evaluation of ERK1/2 (zeige MAPK1/3 Antikörper) inhibitors
MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis.
Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.
This treatment had no effect in PR(cre/+)Mig-6(f/f) mice where Mig-6 was deleted in both the epithelial and stromal compartments of the uterus.
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins\; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene.
ERBB receptor feedback inhibitor 1
, mitogen-inducible gene 6 protein
, mitogen-inducible gene 6-like protein
, ERBB receptor feedback inhibitor 1-like
, receptor-associated late transducer
, mitogen-inducible gene 6 protein homolog
, gene 33 polypeptide
, 60S ribosomal protein L36a
, 60S ribosomal protein L44
, L44-like ribosomal protein
, cell growth-inhibiting gene 15 protein
, cell migration-inducing gene 6 protein
, dJ164F3.3 (ribosomal protein L44)