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These results suggest that stabilization of delta-catenin (zeige CTNND2 ELISA Kits) by Hakai (zeige CBLL1 ELISA Kits) is dependent on Src (zeige SRC ELISA Kits).
These results uncover a new role for p120 catenin bound to the N-cadherin (zeige CDH2 ELISA Kits) precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.
The BC cells showed the coexpression of E- and P-cadherins, as well as release of the molecules b- and p120-catenins into the cytoplasm of tumor cells, which leads to the activation of intracellular mechanisms for changing the structure of the cytoskeleton and the level of proliferation
recent results describing actions of p120-catenin in different phases of this pathway
The mTOR (zeige FRAP1 ELISA Kits)-dependent, epithelial phenotype of TSC (zeige SLC12A3 ELISA Kits) astrocytes suggests TSC1 (zeige TSC1 ELISA Kits)/2 and mTOR (zeige FRAP1 ELISA Kits) tune the phosphorylation level of catenin delta-1 by controlling PKCe (zeige PRKCE ELISA Kits) activity, thereby regulating the mesenchymal-epithelial-transition (MET)
Src (zeige SRC ELISA Kits)-dependent phosphorylation of p120(ctn) can respond rapidly to negative pressure and contribute to E-cadherin (zeige CDH1 ELISA Kits) downregulation.
p120 (zeige HNRNPU ELISA Kits) participates in the progress of gastric cancer through regulating Rac1 and Pak1 (zeige PAK1 ELISA Kits).
The overexpression of P120ctn led to a decrease in both invasion and migration capacity of HN12 cells accompanied by a decrease in EMT (zeige ITK ELISA Kits) markers. Knockdown of P120ctn led to an increase in both invasion and migration capacity accompanied by an increase in EMT (zeige ITK ELISA Kits) markers.
OGT inhibited the formation of the Ecadherin/catenin complex through reducing the interaction between p120 and Ecadherin.
Immunohistochemical panel of CDX2, p120ctn, c-Myc, and Jagged1 proteins would be to distinguish between low/high grade dysplasia in histologically challenging cases of Barrett's esophagus.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin (zeige CDH1 ELISA Kits), but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin (zeige CDH1 ELISA Kits) loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso (zeige ZBTB33 ELISA Kits)-dependent expression of Wnt11 (zeige WNT11 ELISA Kits), is reported.
Delta-catenin (zeige CTNND2 ELISA Kits) activates Rac1 and Cdc42 (zeige CDC42 ELISA Kits) but inhibits RhoA (zeige RHOA ELISA Kits) in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST (zeige Rcor2 ELISA Kits) and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
p120-RhoA-GTPase-mediated signaling can differentially regulate the migratory behavior of epidermal cells, which has potential implications for chronic wound responses and cancer.
p120 functions as a differential regulator of TLR4 signaling pathways by facilitating TLR4 endocytic trafficking in macrophages, and support a novel role for p120 in influencing the macrophages in the lung inflammatory response to endotoxin.
Upregulation of Rac1 activity by Wnt3a (zeige WNT3A ELISA Kits) temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2 (zeige VAV2 ELISA Kits).
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A (zeige DYRK1A ELISA Kits) positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (zeige ZBTB33 ELISA Kits) (and canonical Wnt (zeige WNT2 ELISA Kits)) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt (zeige WNT2 ELISA Kits) pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin (zeige CTNNB1 ELISA Kits).
delta-catenin (zeige CTNND2 ELISA Kits) has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like