Adrenergic, Beta, Receptor Kinase 1 Proteine (ADRBK1)

Bezeichnung:
Adrenergic, Beta, Receptor Kinase 1 Proteine (ADRBK1)
Auf www.antikoerper-online.de finden Sie aktuell 10 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Adrenergic, Beta, Receptor Kinase 1 Antikörper (131) und Adrenergic, Beta, Receptor Kinase 1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 176 Adrenergic, Beta, Receptor Kinase 1 Produkte verfügbar.
Synonyme:
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
alle Proteine anzeigen Gen GeneID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Am meisten referenzierte Adrenergic, Beta, Receptor Kinase 1 Proteine

  1. Human ADRBK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004759 : Aragay, Mellado, Frade, Martin, Jimenez-Sainz, Martinez-A, Mayor: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
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Weitere Proteine zu Adrenergic, Beta, Receptor Kinase 1 Interaktionspartnern

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. Enhanced GRK2 expression triggers cardiac hypertrophy by GRK2-PI3Kgamma mediated Akt phosphorylation and subsequent inactivation of GSK3beta.

  2. Grk2 rescuing activity requires the integrity of domains essential for its interaction with GPCRs, we speculate that Grk2 may regulate Hh pathway activity by downregulation of a GPCR.

  3. The main novelty presented here is to show that septic shock induces cardiac hyporesponsiveness to isoproterenol by a mechanism dependent on nitric oxide and mediated by G protein-coupled receptor (zeige GPR34 Proteine) kinase isoform 2. Therefore, G protein-coupled receptor (zeige GPR34 Proteine) kinase isoform 2 inhibition may be a potential therapeutic target in sepsis-induced cardiac dysfunction.

  4. Data, including data from studies in heterozygous knockout mice, suggest that Grk2 is involved in TNFalpha (zeige TNF Proteine)-induced wound healing in epithelial cells of the colon; Grk2 appears to inhibit TNFalpha (zeige TNF Proteine)-induced apoptosis; Grk2 inhibits TNFalpha (zeige TNF Proteine)-induced ERK (zeige EPHB2 Proteine) activation by inhibiting generation of reactive oxygen species. Homozygous knockout of Grk2 is embryonically lethal in mice.

  5. GRK2 upregulation causes kappa-opioid receptor (zeige OPRK1 Proteine) desensitization in diabetic heart

  6. study provides the first insights into the role of GRK2 in skeletal muscle physiology and points to a role for GRK2 as a modulator of contractile properties in skeletal muscle as well as beta2AR (zeige ADRB2 Proteine)-induced hypertrophy.

  7. GRK2 loss confers a protective advantage over control mice after myocardial ischemia/reperfusion injury. Fibroblast GRK2 knockout mice presented with decreased infarct size and preserved cardiac function 24 hours post ischemia/reperfusion. They had decreased fibrosis and fibrotic gene expression. These protective effects correlated with decreased infiltration of neutrophils to the ischemia site and decreased TNF-alpha (zeige TNF Proteine).

  8. this study shows that astragaloside IV alleviates E. coli-caused peritonitis through modulating GRK2-CXCR2 (zeige CXCR2 Proteine) signal in neutrophils

  9. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  10. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (zeige GNAQ Proteine)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.

  2. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (zeige GRK4 Proteine).

  3. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  4. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  5. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  6. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  7. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (zeige POLG Proteine) and renders the channels insensitive to inhibition by Nedd4-2 (zeige NEDD4L Proteine).

  8. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  9. Resultrs suggest that activated platelet-derived growth factor receptor-beta (zeige PDGFRB Proteine) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  10. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (zeige OPRM1 Proteine)

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. GRK2 is negatively related to IGF1R (zeige IGF1R Proteine) and IGF1R (zeige IGF1R Proteine), but not GRK2, was associated with the tumour-node-metastasis stage and overall and disease-free survival in hepatocellular carcinoma.

  2. The tyrosine-phosphorylated GRK2 mediates this inhibition by acting on the second intracellular loop of D3R.

  3. GRK2 is overexpressed in pancreatic cancer, and might serve as a potential indicator of unfavorable prognosis.

  4. Data, including data from studies in heterozygous knockout mice, suggest that GRK2 is involved in TNFalpha (zeige TNF Proteine)-induced wound healing in epithelial cells of the colon; GRK2 appears to inhibit TNFalpha (zeige TNF Proteine)-induced apoptosis; GRK2 inhibits TNFalpha (zeige TNF Proteine)-induced ERK (zeige EPHB2 Proteine) activation by inhibiting generation of reactive oxygen species. Homozygous knockout of GRK2 is embryonically lethal in mice.

  5. The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.

  6. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (zeige HDAC6 Proteine) and Pin1 (zeige PIN1 Proteine).

  7. GRK2 may inhibit IGF1 (zeige IGF1 Proteine)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (zeige EGR1 Proteine).

  8. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  9. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  10. Suggest role for GRK2 in the regulating cardiac hypertrophy.

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Protein Überblick

Protein Überblick

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497)
  • adrenergic, beta, receptor kinase 1 (adrbk1)
  • adrenergic receptor kinase, beta 1 (Adrbk1)
  • adrenergic, beta, receptor kinase 1 (ADRBK1)
  • adrenergic, beta, receptor kinase 1 (Adrbk1)
  • Adrbk-1 Protein
  • Bark-1 Protein
  • BARK1 Protein
  • BETA-ARK1 Protein
  • betaARK1 Protein
  • GRK-2 Protein
  • Grk2 Protein

Bezeichner auf Proteinebene für ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

GENE ID SPEZIES
10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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