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Adrenergic, Beta, Receptor Kinase 1 ELISA Kits (ADRBK1)
Auf finden Sie aktuell 12 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) ELISA Kits von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Adrenergic, Beta, Receptor Kinase 1 Antikörper (129) und Adrenergic, Beta, Receptor Kinase 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 166 Adrenergic, Beta, Receptor Kinase 1 Produkte verfügbar.
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) ELISA Kits nach Reaktivitäten

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Weitere ELISA Kits für Adrenergic, Beta, Receptor Kinase 1 Interaktionspartner

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (zeige GNAQ ELISA Kits)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  2. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

  3. Erythropoietin (zeige EPO ELISA Kits) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  4. In vitro, GRK2 inhibits Epac1 (zeige RAPGEF3 ELISA Kits)-to-Rap1 (zeige TERF2IP ELISA Kits) signaling by phosphorylation of Epac1 (zeige RAPGEF3 ELISA Kits) at Ser (zeige SIGLEC1 ELISA Kits)-108 in the Disheveled/Egl-10/pleckstrin (zeige PLEK ELISA Kits) domain. GRK2 inhibits Epac1 (zeige RAPGEF3 ELISA Kits)-mediated sensitization of Piezo2 (zeige FAM38B ELISA Kits) which contributes to inflammatory mechanical hyperalgesia.

  5. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  6. These results suggest GRK2 contributes to melanopsin (zeige OPN4 ELISA Kits) deactivation, but that other mechanisms account for most of modulation of melanopsin (zeige OPN4 ELISA Kits) activity in ipRGCs.

  7. data suggest that inhibiting GRK2 could reverse an established insulin (zeige INS ELISA Kits)-resistant and obese phenotype

  8. Post-MI AdipoR1 (zeige ADIPOR1 ELISA Kits) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (zeige ADIPOR1 ELISA Kits) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  9. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

  10. Data indicate that G protein-coupled receptor kinase 2 (GRK2) downregulation enhances insulin (zeige INS ELISA Kits) signaling in adult mouse hearts.

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (zeige GRK4 ELISA Kits).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2.

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (zeige PDGFRB ELISA Kits) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (zeige OPRM1 ELISA Kits)

  10. atomic structure of GRK2 in complex with Galphaq (zeige GNAQ ELISA Kits) and Gbetagamma, in which activated Galpha (zeige SUCLG1 ELISA Kits) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (zeige GNAQ ELISA Kits), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Interaktionspartner

  1. GRK2 may inhibit IGF1 (zeige IGF1 ELISA Kits)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (zeige EGR1 ELISA Kits).

  2. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  3. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  4. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  5. the dual-specific GRK2 and ERK (zeige EPHB2 ELISA Kits) cascade inhibitor, RKIP (Raf kinase inhibitor protein (zeige PEBP1 ELISA Kits)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (zeige PPARG ELISA Kits)-regulated genes.

  6. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  7. It plays a role in progression of Vasculature which is affected by insulin (zeige INS ELISA Kits) resistance and type 2 diabetes expresses high levels of GRK2

  8. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (zeige CXCR2 ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling.

  9. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

  10. Data indicate that protein kinase (zeige CDK7 ELISA Kits) GRK2 silencing abolished isoproterenol-induced phosphorylation of beta2-adrenergic receptor (zeige ADRB2 ELISA Kits) (beta2ARs).

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antigen-Profil

Beschreibung des Gens

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (adrbk1) Elisa Kit
  • adrenergic receptor kinase, beta 1 (Adrbk1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (ADRBK1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (Adrbk1) Elisa Kit
  • Adrbk-1 Elisa Kit
  • Bark-1 Elisa Kit
  • BARK1 Elisa Kit
  • BETA-ARK1 Elisa Kit
  • betaARK1 Elisa Kit
  • GRK-2 Elisa Kit
  • Grk2 Elisa Kit

Bezeichner auf Proteinebene für ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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