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alpha2B KO mice exhibit altered locomotor behaviors and compulsive burying behavior, are acutely sensitive to the stereotypy effects of the psychostimulant amphetamine; an identical tendency in alpha2C KO mice administered the alpha2B-receptor-selective antagonist AGN-209419 with amphetamine. Findings suggest a compulsive phenotype for alpha2B KO mice, and a broader role for the alpha2B receptor.
Data indicate that In arrestin 3 (zeige ARRB2 ELISA Kits) deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin (zeige PPP1R9B ELISA Kits), the hypertensive response is enhanced.
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
Demonstrate that both A(2A)ARs (zeige SLURP1 ELISA Kits) and A(2B)ARs (zeige SLURP1 ELISA Kits) induce coronary flow changes through K(ATP) channels.
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog (zeige SHH ELISA Kits)-mediated proliferation of mesenchymal cells and thus prevent respiratory failure
alpha2B adrenoceptor regulated expression is examined in mouse brain development
by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin (zeige PPP1R9B ELISA Kits) reduces arrestin (zeige SAG ELISA Kits)- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) activity after endocytosis
Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase (zeige NOS ELISA Kits) inhibition.
alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.
Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.
This study demonstrated that a deletion variant of the ADRA2B gene encoding the alpha2b-adrenoceptor reduces the stress-induced shift from hippocampal cognitive toward dorsal striatal habit memory.
These results identify a beta2-adrenergic-Ca(2+)-actin axis as a new regulator of cell deformability.
ADRA2B SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.
These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.
role of GGA3 (zeige GGA3 ELISA Kits) in the cell surface export of alpha2B-adrenergic receptor
Common polymorphisms in the ADRA2B gene are not associated with orthostatic hypotension risk in Chinese.
The results of this study suggested that ADRA2B is closely related to the individual difference in human attention orientation, but not to the individual difference in emotional processing.
ADRA2B deletion carriers showed decreased neural activity in the amygdala when recognizing emotional faces in control condition and increased amygdala activity under stress.
The ADRA2B deletion variant may selectively predict stress effects on memory in females.
Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.
, alpha-2B adrenergic receptor
, alpha-2B adrenoceptor
, alpha-2B adrenoreceptor
, adrenergic receptor, alpha 2b
, adrenergic, alpha-2B-, receptor
, alpha 2b adrenergic receptor
, adrenergic receptor alpha-2B
, alpha-2B adrenergic receptor-like
, subtype alpha2-C2
, alpha adrenergic receptor subtype 2B
, Adrenergic alpha2B- receptor class III
, Adrenergic, alpha2B-, receptor class III
, ADRA2B adrenergic, alpha-2B-, receptor
, G-protein coupled receptor
, adrenergic receptor alpha 2B
, alpha-2 adrenergic receptor subtype C2
, alpha-2-adrenergic receptor-like 1