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anti-Mouse (Murine) ADCY8 Antikörper:
anti-Human ADCY8 Antikörper:
anti-Rat (Rattus) ADCY8 Antikörper:
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This study demonstrated a cell-autonomous requirement for ADCY8 in retinal neurons for normal midline crossing. These findings are the first to show that ADCY8 is required for axonal pathfinding before axons reach their targets.
Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 (zeige HRASLS Antikörper) abolished long-lasting anxiety.
Dysregulation of a survival pathway in adenylyl cyclase 1 (zeige ADCY1 Antikörper) and 8 knockout mice was identified following early-life ethanol exposure.
Study shows that AC8 is involved in epileptogenesis, and may serve as a potential target for the treatment of epilepsy
ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin (zeige INS Antikörper) secretion.
these results support a complex role of cAMP signaling pathways confirming the involvement of AC8 in the modulation of stress responses.
ACVIII gene is regulated by CREB (zeige CREB1 Antikörper) in vitro and in vivo and this regulation may contribute to CREB (zeige CREB1 Antikörper)-dependent neural plasticity
AC8 accumulates in puncta of dendrites and axons in hippocampal neurons and localizes with synaptic marker proteins indicating synaptic and nonsynaptic cAMP signals generated by different Ca2 (zeige CA2 Antikörper)+-stimulated adenylyl cyclases are required for mossy fiber LTP (zeige SCP2 Antikörper)
AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord.
AC8 protein levels were abundant during development, with diffuse and increasing expression in the hippocampus that intensified in the CA1 (zeige CA1 Antikörper)/CA2 (zeige CA2 Antikörper) region by adulthood. in the presynaptic active zone and extrasynaptic fractions.
data suggest that AC1 (zeige HRASLS Antikörper)/AC8 are crucial activators of cell survival signaling pathways acutely following ethanol exposure and represent molecular factors that may directly modulate the severity of symptoms associated with Fetal Alcohol Syndrome
Our results provide evidence for new loci influencing abdominal visceral (BBS9 (zeige BBS9 Antikörper), ADCY8, KCNK9 (zeige KCNK9 Antikörper)) and subcutaneous (MLLT10 (zeige MLLT10 Antikörper)/DNAJC1 (zeige DNAJC1 Antikörper)/EBLN1 (zeige EBLN2 Antikörper)) fat, and confirmed a locus (THNSL2 (zeige THNSL2 Antikörper)) previously reported to be associated with abdominal fat in women
Results show that promoter hypermethylation of ADCY8, CDH8 (zeige CDH8 Antikörper), and ZNF582 (zeige ZNF582 Antikörper) are correlated with high-grade squamous intraepithelial lesion.
ADCY8 is integral for long-term potentiation and synaptic plasticity and is implicated in fear-related learning and memory.
Polymorphisms ADCY8 are associated with an alcohol-dependent phenotype in females, which is distinguished by comorbid signs of depression.
The adenylate cyclase 8 plays a major role in cAMP production.
Orai1 (zeige ORAI1 Antikörper) and AC8 binding mediates dynamic interplay between Ca2 (zeige CA2 Antikörper)+ and cAMP signaling
cAMP-mediated pathways are modelled by glucose, and downregulation of the calcium-sensitive ADCY8 plays a central role herein, including signalling via the GLP1R (zeige GLP1R Antikörper).
Ca2 (zeige CA2 Antikörper)+ entry increase was accompanied by red cell aggregation rise, while adenylyl cyclase-cAMP system stimulation led to red cell deformability increase and its aggregation lowered.
Data reveal that an association of the Ca(2 (zeige CA2 Antikörper)+)-stimulable AC8 with AKAP79 (zeige AKAP5 Antikörper)/150 that limits the sensitivity of AC8 to intracellular Ca(2 (zeige CA2 Antikörper)+) events.
CaM is collapsed around the adenylyl cyclase 8 peptides that binds to CaM in an antiparallel orientation.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase
adenylate cyclase 8 (brain)
, adenylate cyclase type VIII
, adenylate cyclase type 8
, adenylate cyclase type 8-like
, ATP pyrophosphate-lyase 8
, adenylyl cyclase 8
, ca(2+)/calmodulin-activated adenylyl cyclase
, adenylyl cyclase-8, brain
, type VIII adenylyl cyclase
, adenylate cyclase 3