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At least one of the functions of Drosophila Tel2/EpsinR is regulation of Wingless signaling.
Epsins are required for Dishevelled (zeige DVL2 ELISA Kits) stability and Wnt (zeige WNT2 ELISA Kits) signalling activation in colon cancer development.
our data identify Epsin2 as a novel player in regulating oocyte maturation, and demonstrate that Epsin2 promotes polarity establishment and meiotic division via activating Cdc42 (zeige CDC42 ELISA Kits)
epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 (zeige FLT4 ELISA Kits) abundance and signaling in collecting lymphatic trunks during lymphatic valve formation
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
Epsins function specifically to downregulate VEGFR2 by mediating activated VEGFR2 internalization and degradation and that genetic reduction of VEGFR2 level protects against excessive angiogenesis caused by epsin loss.
Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function.
epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch (zeige NOTCH1 ELISA Kits) signaling in mammals
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
, lethal (3) SG62
, liquid facet related
, liquid facets related
, liquid-facets related
, epsin 2
, Epsin 2
, EPS-15-interacting protein 2
, Eps15 binding protein
, intersectin-EH-binding protein 2
, EH domain binding protein epsin 2
, mitotic phosphoprotein 90