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Collectively, this study illustrates the interplay between ALDH(high) CSCLs and EOC invasion, and offers a novel application target for the EOC oncotherapy.
Findigs suggest that aldehyde dehydrogenase 1 (ALDH1) played an important role in tumor aggressiveness and associated with a tumor-promoting microenvironment in esophageal cancer.
These results suggested that tumor-secreting factor increases ALDH(high) TEC (zeige NR4A3 ELISA Kits) populations that are resistant to 5-FU. Therefore, ALDH(high) TEC (zeige NR4A3 ELISA Kits) in tumor blood vessels might be an important target to overcome or prevent drug resistance.
Results demonstrate that EZH2 (zeige EZH2 ELISA Kits) and ALDH1 proteins are expressed in the stromal component of phyllodes tumors.
High ALDH1A1 expression is associated with cervical cancer.
Study shows that BPA (zeige DST ELISA Kits) induces ALDH1 expression in MCF-7 Cells and increases mammosphere size.
High ALDH expression is associated with Prostate Cancer.
High ALDH1 expression is associated with endometrial cancer.
A central role of Aurora kinase A (AURKA (zeige AURKA ELISA Kits)) in promoting Epithelial-to-mesenchymal transition and cancer stem cell phenotypes via ALDH1A1.
ALDH1A1 modulates the production of ROS (zeige ROS1 ELISA Kits) by anti-cancer agents such as paclitaxel and diminishes their efficacy.
analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2 (zeige ALDH2 ELISA Kits)
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO (zeige NONO ELISA Kits))/paraspeckle protein component 1 (PSPC1 (zeige PSPC1 ELISA Kits))-aldehyde dehydrogenase 1 (NONO (zeige NONO ELISA Kits)/PSPC1 (zeige PSPC1 ELISA Kits)-ALDH1A1) in the modulation of Sertoli cells (SCs (zeige TWIST1 ELISA Kits)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed.
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis
these experiments reveal an evolutionarily conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).
Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A.
Dkk-1 (zeige DKK1 ELISA Kits) enhances resistance of osteosarcoma cells to stress by tipping balance of Wnt (zeige WNT2 ELISA Kits) signaling in favor of the non-canonical Jun (zeige JUN ELISA Kits)-mediated Wnt (zeige WNT2 ELISA Kits) pathways. In turn, this results in transcriptional activation of ALDH1 through Jun (zeige JUN ELISA Kits)-responsive promoter elements.
Deletion of Aldh1a1 exacerbated alpha-synuclein-mediated DA neurodegeneration and alpha-synuclein aggregation, whereas Aldh1a1-null and control DA neurons were comparably susceptible to 1-methyl-4-phenylpyridinium-, glutamate (zeige GRIN1 ELISA Kits)-, or camptothecin-induced cell death.
Our findings indicated that increased expression of ALDH1A1 in nasopharyngeal carcinoma was associated with enhanced invasiveness in the nude mouse.
PSMB8 (zeige PSMB8 ELISA Kits), ALDH1A1, and HSPA4 (zeige HSPA4 ELISA Kits) were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
beta-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA (zeige RHOA ELISA Kits)/Rock signaling
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.
aldehyde dehydrogenase 1A1
, retinal dehydrogenase 1
, aldehyde dehydrogenase 1 family, member A1
, aldehyde dehydrogenase class 1
, retinal dehydrogenase 1-like
, aldehyde dehydrogenase
, aldehyde dehydrogenase family protein
, NADP-dependent fatty aldehyde dehydrogenase
, ALDH class 1
, RALDH 1
, acetaldehyde dehydrogenase 1
, aldehyde dehydrogenase 1, soluble
, aldehyde dehydrogenase, liver cytosolic
, retinaldehyde dehydrogenase 1
, chromosome 1 GSS clone AHT1-34
, aldehyde dehydrogenase 1, subfamily A1
, aldehyde dehydrogenase 2
, aldehyde dehydrogenase family 1 member A1
, aldehyde dehydrogenase family 1, member A1
, aldehyde dehydrogenase family 1, subfamily A1
, aldehyde dehydrogenase, cytosolic
, cytosolic aldehyde dehydrogenase
, ALDH class 2
, aldehyde dehydrogenase 2, mitochondrial
, aldehyde dehydrogenase, mitochondrial
, mitochondrial aldehyde dehydrogenase
, alcohol dehydrogenase family 1, subfamily A1
, alcohol dehydrogenase family 1, subfamily A2
, aldehyde dehydrogenase 1, liver cytosolic (class 1)