XRCC2 Proteine (XRCC1)

Bezeichnung:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2 Proteine (XRCC1)
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Synonyme:
4921524O04Rik, 8030409M04Rik, RAD51, RecA, RGD1564823, XRCC2
alle Proteine anzeigen Gen GeneID UniProt
XRCC1 7516 O43543
Maus XRCC1 XRCC1 57434 Q9CX47
Ratte XRCC1 XRCC1 499966  

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Weitere Proteine zu XRCC2 Interaktionspartnern

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2 (XRCC1) Interaktionspartner

  1. XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 (zeige RAD51 Proteine) paralog so identified. XRCC2 is required to maintain levels of other RAD51 (zeige RAD51 Proteine) paralogs that are normally present in XRCC2-RAD51B (zeige Rad51B Proteine)-C-D complex.

  2. Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma.

  3. Results indicate that eight polymorphisms of XRCC1, XRCC2, and XRCC3 (zeige XRCC3 Proteine) gene might be related to individual susceptibility to differentiated thyroid cancer (DTC) in Chinese population suggesting that XRCC1 (rs25487, rs25489, rs1799782), XRCC2 (rs3218536), and XRCC3 (zeige XRCC3 Proteine) (rs1799794, rs56377012, rs1799796, rs861539) are novel genetic risk markers for DTC.

  4. Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 (zeige XRCC3 Proteine) Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.

  5. Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients.

  6. The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis)

  7. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms in the genes involved in Homologous recombination repair, RAD51 (zeige RAD51 Proteine), RAD51B (zeige Rad51B Proteine), XRCC2 and XRCC3 (zeige XRCC3 Proteine).

  8. In conclusion, XRCC2 Arg188His and XRCC3 (zeige XRCC3 Proteine) Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.

  9. XRCC2 protein expression of colorectal cancer Chinese Han patients with CT/TT genotypes were significantly higher than CC genotype.

  10. The GA genotype of the Arg188His polymorphism of XRCC2 was associated with increased risk of breast cancer in a Pakistani cohort.

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2 (XRCC1) Interaktionspartner

  1. Data show that XRCC2 and other homologous recombination proteins, including the key recombinase (zeige RAG1 Proteine) RAD51 (zeige RAD51 Proteine), co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle.

  2. These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc (zeige APC Proteine)(min/+) background but increases the tumorigenic response to radiation.

  3. An important function of XRCC2 is to enhance the activity of RAD51 (zeige RAD51 Proteine), so that the loss of XRCC2 results in a severe delay in the early response of RAD51 (zeige RAD51 Proteine) to DNA damage.

  4. Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts.

  5. the normal developmental programme is perturbed in Xrcc2-/- embryonic tissues, particularly during neurogenesis and somitogenesis

  6. ATP hydrolysis by Rad51 (zeige RAD51 Proteine) is more important for some homologous recombination functions than it is for other aspects of DNA repair

  7. Xrcc2 is important to preserve or restore replication forks during rapid clonal expansion of developing lymphocytes.

  8. DNA replication licensing factor MCM2 (zeige MCM2 Proteine) and DNA mismatch repair (MMR (zeige MRC1 Proteine)) protein MSH2 (zeige MSH2 Proteine) were confirmed to be present in co-precipitations with MmXRCC2.

XRCC2 (XRCC1) Protein Überblick

Protein Überblick

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.

Alternative names and synonyms associated with XRCC2 (XRCC1)

  • X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2)
  • X-ray repair complementing defective repair in Chinese hamster cells 2 (LOC100218547)
  • X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2)
  • 4921524O04Rik Protein
  • 8030409M04Rik Protein
  • RAD51 Protein
  • RecA Protein
  • RGD1564823 Protein
  • XRCC2 Protein

Bezeichner auf Proteinebene für XRCC1

X-ray repair cross complementing protein 2 , X-ray repair complementing defective repair in Chinese hamster cells 2 , DNA repair protein XRCC2 , X-ray repair cross-complementing protein 2 , recA/RAD51 family protein

GENE ID SPEZIES
420438 Gallus gallus
717006 Macaca mulatta
738997 Pan troglodytes
100218547 Taeniopygia guttata
7516 Homo sapiens
475548 Canis lupus familiaris
789410 Bos taurus
57434 Mus musculus
499966 Rattus norvegicus
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