anti-Ubiquitin Interaction Motif Containing 1 (UIMC1) Antikörper

Bezeichnung:
anti-Ubiquitin Interaction Motif Containing 1 Antikörper (UIMC1)
Auf www.antikoerper-online.de finden Sie aktuell 70 Ubiquitin Interaction Motif Containing 1 (UIMC1) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Ubiquitin Interaction Motif Containing 1 Proteine (6) und Ubiquitin Interaction Motif Containing 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 90 Ubiquitin Interaction Motif Containing 1 Produkte verfügbar.
Synonyme:
9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RGD1307009, RIP110, Rxrip110, UIMC1, X2HRIP110

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Am meisten referenzierte anti-Ubiquitin Interaction Motif Containing 1 Antikörper

  1. Human Polyclonal UIMC1 Primary Antibody für WB - ABIN1944736 : Yan, Kim, Jetten: RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 3 Referenzen für 1944736

  2. Human Polyclonal UIMC1 Primary Antibody für ICC, IF - ABIN4349369 : Lin, Ratner, Whicker, Lee, Sartorelli: Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. in Molecular cancer research : MCR 2014 (PubMed)
    Zeige alle 3 Referenzen für 4349369

  3. Human Polyclonal UIMC1 Primary Antibody für ICC, IF - ABIN250739 : Yan, Kim, Yang, Li, Liao, Xia, Jetten: The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. in Cancer research 2007 (PubMed)
    Zeige alle 3 Referenzen für 250739

Weitere Antikörper gegen Ubiquitin Interaction Motif Containing 1 Interaktionspartner

Human Ubiquitin Interaction Motif Containing 1 (UIMC1) Interaktionspartner

  1. Low RAP80 mRNA expression correlates with sporadic high-grade serous ovarian carcinoma.

  2. RAP80 is a critical gatekeeper in impeding epithelial-mesenchymal transition-induced metastasis and malignant phenotypes of cancer as well as preserving DNA integrity.

  3. Data suggest that RAP80 SIM (zeige SIM2 Antikörper) (SUMO interacting motif) binds SUMO-2 (zeige SUMO2 Antikörper); both specificity and affinity are enhanced through phosphorylation of canonical CK2 (zeige CSNK2A1 Antikörper) (casein kinase 2) site within the SIM (zeige SIM2 Antikörper).

  4. Impaired TIP60 (zeige KAT5 Antikörper)-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 (zeige TP53BP1 Antikörper) and RAP80 in Fanconi anemia (zeige PALB2 Antikörper) pathway-deficient cells.

  5. TRAIP/RNF206 (zeige TRAIP Antikörper) is required for recruitment of RAP80 to sites of DNA damage.(

  6. A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex.

  7. patients with low RAP80 expression received gemcitabine/cisplatin, those with intermediate/high RAP80 expression and low/intermediate BRCA1 expression received docetaxel/cisplatin

  8. Data indicate that a single point deletion (DeltaE81) in RAP80 abrogates multivalent interactions with polyubiquitin (zeige UBB Antikörper).

  9. connect ubiquitin- and SUMO-dependent DSB recognition, revealing that RNF4-synthesized hybrid SUMO-ubiquitin chains are recognized by RAP80 to promote BRCA1 recruitment and DNA repair.

  10. post-translational phosphorylation of RAP80 by the Cdk1 (zeige CDK1 Antikörper)-cyclin B(1) complex is important for RAP80 functional sensitivity to IR and G(2)/M checkpoint control.

Mouse (Murine) Ubiquitin Interaction Motif Containing 1 (UIMC1) Interaktionspartner

  1. Data indicate that RAP80-deficiency promotes genomic instability and causes an increase in cancer risk consistent with the concept that RAP80 exhibits a tumor suppressor function.

  2. a model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites.

  3. Mechanistically, loss of RAP80 suppresses recruitment of the BRCA1-A complex to DNA damage sites and abrogates the DNA damage repair process at DNA damage sites.

  4. Both ubiquitin-interacting motif 1(UIM1) and UIM2 of RAP80 recognize an Ile 44-centered hydrophobic patch on ubiquitin but neither UIM interacts with the Lys (zeige LYZ Antikörper) 63-linked isopeptide bond. [RAP80]

Ubiquitin Interaction Motif Containing 1 (UIMC1) Antigen-Profil

Beschreibung des Gens

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).

Alternative names and synonyms associated with Ubiquitin Interaction Motif Containing 1 (UIMC1)

  • ubiquitin interaction motif containing 1 (UIMC1) Antikörper
  • ubiquitin interaction motif containing 1 (LOC100354766) Antikörper
  • retinoid x receptor interacting protein (RAP80) Antikörper
  • ubiquitin interaction motif containing 1 (Uimc1) Antikörper
  • 9430016E08Rik Antikörper
  • D330018D10Rik Antikörper
  • D630032M02Rik Antikörper
  • RAP80 Antikörper
  • RGD1307009 Antikörper
  • RIP110 Antikörper
  • Rxrip110 Antikörper
  • UIMC1 Antikörper
  • X2HRIP110 Antikörper

Bezeichner auf Proteinebene für UIMC1

ubiquitin interaction motif containing 1 , BRCA1-A complex subunit RAP80-like , BRCA1-A complex subunit RAP80 , receptor-associated protein 80 , ubiquitin interaction motif-containing protein 1 , receptor associated protein 80 , retinoid X receptor-interacting protein 110 , retinoid x receptor interacting protein , retinoid X receptor interacting protein 110

GENE ID SPEZIES
416145 Gallus gallus
462299 Pan troglodytes
611298 Canis lupus familiaris
705412 Macaca mulatta
100354766 Oryctolagus cuniculus
100408353 Callithrix jacchus
100458657 Pongo abelii
100464583 Ailuropoda melanoleuca
100582019 Nomascus leucogenys
100037949 Sus scrofa
51720 Homo sapiens
20184 Mus musculus
290997 Rattus norvegicus
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