Replication Protein A1, 70kDa (RPA1) ELISA Kits

Bezeichnung:
Replication Protein A1, 70kDa ELISA Kits (RPA1)
Auf www.antikoerper-online.de finden Sie aktuell 4 Replication Protein A1, 70kDa (RPA1) ELISA Kits von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Replication Protein A1, 70kDa Antikörper (120) und Replication Protein A1, 70kDa Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 139 Replication Protein A1, 70kDa Produkte verfügbar.
Synonyme:
70kDa, 5031405K23Rik, AA589576, AW557552, Cb1-727, CG9633, D-RPA70, D-SSB, Dmel\\CG9633, DmRPA, dmrpa1, dRP-A, HSSB, i164, LOC100230990, MST075, Mt-SSB, MtSSB, REPA1, RF-A, rp-a, Rpa, Rpa-70, RPA1, rpa70, RPA 70, RPA 70 kDa, Ssb-70, Ssbp1, wu:fi14b08, zgc:55337, zgc:77092
list all ELISA KIts Gen GeneID UniProt
Maus RPA1 RPA1 68275 Q8VEE4
RPA1 287524  
RPA1 6117 P27694

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Replication Protein A1, 70kDa (RPA1) ELISA Kits nach Reaktivitäten

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Weitere ELISA Kits für Replication Protein A1, 70kDa Interaktionspartner

Fruit Fly (Drosophila melanogaster) Replication Protein A1, 70kDa (RPA1) Interaktionspartner

  1. loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts

  2. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.

Mouse (Murine) Replication Protein A1, 70kDa (RPA1) Interaktionspartner

  1. The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.

  2. LT prevents recruitment of RPA to nuclear foci after DNA damage. This leads to failure to recruit repair proteins such as Rad51 (zeige RAD51 ELISA Kits) or Rad9 (zeige RAD9A ELISA Kits), explaining why LT prevents repair of double strand DNA breaks by homologous recombination.

  3. Most RPA recruitment during class switch recombination represents salvage of unrepaired breaks by homology-based pathways during the S-G2 (zeige STRN3 ELISA Kits)/M phase of the cell cycle.

  4. POT1a (zeige POT1 ELISA Kits) degradation resulted in rapid and reversible activation of the ATR (zeige ATR ELISA Kits) pathway in G1 and S/G2 (zeige STRN3 ELISA Kits).

  5. Rpa1(L230P) missense mutation significantly alters the tumor phenotype and spectrum of Trp53 (zeige TP53 ELISA Kits) mutant mice by modifying the genetic mechanisms underlying tumorigenesis.

  6. both TNFR-p55 (zeige TNFRSF1A ELISA Kits) and TNFR (zeige TNFRSF1A ELISA Kits)-p75 (zeige NGFR ELISA Kits) appear to be of minimal importance for modulation of Fas (zeige FAS ELISA Kits)-mediated apoptosis and associated A1 protein expression despite normal Fas (zeige FAS ELISA Kits)/TNFR-p55 (zeige TNFRSF1A ELISA Kits) and increased TNFR (zeige TNFRSF1A ELISA Kits)-p75 (zeige NGFR ELISA Kits) expression in neutrophils

  7. Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression.

  8. hyperphosphorylation may play a role in modulating cellular pathways by altering the DNA binding domain-mediated RPA-DNA and RPA-protein interactions, hypothetically via the interaction of hyperphosphorylated RPA32N with DBD-B

  9. These results demonstrate that neither RPA hyper-phosphorylation nor H2AX are required for the formation in RPA intra-nuclear foci in response to DNA damage/replicational stress.

Human Replication Protein A1, 70kDa (RPA1) Interaktionspartner

  1. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  2. Data suggest RAD52 (zeige RAD52 ELISA Kits) binds tightly to RPA/ssDNA complex in presynaptic complex and inhibits RPA turnover; during presynaptic complex assembly, most of RPA and RAD52 (zeige RAD52 ELISA Kits) is displaced from ssDNA, but some RAD52 (zeige RAD52 ELISA Kits)/RPA/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (zeige RAD51 ELISA Kits) filaments. (RAD52 (zeige RAD52 ELISA Kits) = Rad52 (zeige RAD52 ELISA Kits) DNA repair/recombination protein (zeige RAD50 ELISA Kits); RPA = replication protein A; ssDNA = single-stranded DNA; RAD51 (zeige RAD51 ELISA Kits) = Rad51 (zeige RAD51 ELISA Kits) recombinase (zeige RAG1 ELISA Kits))

  3. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen (zeige PCNA ELISA Kits)) to the vicinity of its DNA target site is important; PCNA (zeige PCNA ELISA Kits) can be maintained at or near primer/template junctions during DNA synthesis by RPA (replication protein A) or SSB (single-stranded DNA-binding protein); here, the SSB used was from Escherichia coli.

  4. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.

  5. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (zeige RECQL ELISA Kits) DNA helicase and ERCC1 (zeige ERCC1 ELISA Kits)-XPF (zeige ERCC4 ELISA Kits) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (zeige PARP1 ELISA Kits) and RPA.

  6. RPA deficiency induces activation of the Fanconi anemia pathway in an ATR-dependent manner, which may play a role in the genome maintenance.

  7. Force regulated dynamics of RPA1 on a DNA fork during DNA replication has been reported.

  8. By monitoring DNA double-strand breaks mis (zeige AMH ELISA Kits)-repair using a sensitive bioassay, it was found that depletion of homologous recombination proteins, including BRCA2 (zeige BRCA2 ELISA Kits), BRCA1 or RPA1, resulted in a distinct mutational signature associated with significant increases in break-induced mutation frequencies.

  9. It has been concluded that stable binding and/or the melting of secondary DNA structures by RPA1 is required for DNA repair, including RAD51 (zeige RAD51 ELISA Kits)-mediated DNA strand exchange, but is dispensable for DNA replication.

  10. results reveal that ETAA1 is a novel RPA-interacting protein (zeige RPAIN ELISA Kits) that promotes restart of stalled replication forks.

Xenopus laevis Replication Protein A1, 70kDa (RPA1) Interaktionspartner

  1. This study found that the N-terminus of the RPA large subunit interacts with both WRN and DNA2 (zeige DNA2 ELISA Kits) and is essential for stimulating WRN's 3'->5' helicase (zeige DNA2 ELISA Kits) activity and DNA2 (zeige DNA2 ELISA Kits)'s 5'->3' ss-DNA exonuclease (zeige EXO1 ELISA Kits) activity.

  2. The results provide strong biochemical evidence to link RPA to a specific DSB repair pathway and reveal a novel function of RPA in the generation of 3' ss-DNA for homology-dependent DSB repair.

  3. Replication protein A accumulated increasingly on replication-arrested chromatin.

  4. RPA1 subunit may directly recognize and bind to the 5-formyluracil on the single-stranded DNA.

Replication Protein A1, 70kDa (RPA1) Antigen-Profil

Beschreibung des Gens

Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.

Alternative names and synonyms associated with Replication Protein A1, 70kDa (RPA1)

  • Replication Protein A 70 (RpA-70) Elisa Kit
  • replication protein A1, 70kDa (RPA1) Elisa Kit
  • replication protein A1, 70kDa (rpa1) Elisa Kit
  • replication protein A1, 70kDa (LOC100230990) Elisa Kit
  • replication protein A1 (LOC100341460) Elisa Kit
  • replication protein A1 (Rpa1) Elisa Kit
  • replication protein A1 (rpa1) Elisa Kit
  • Sjogren syndrome antigen B (autoantigen La) (SSB) Elisa Kit
  • uncharacterized LOC100298705 (LOC100298705) Elisa Kit
  • 70kDa Elisa Kit
  • 5031405K23Rik Elisa Kit
  • AA589576 Elisa Kit
  • AW557552 Elisa Kit
  • Cb1-727 Elisa Kit
  • CG9633 Elisa Kit
  • D-RPA70 Elisa Kit
  • D-SSB Elisa Kit
  • Dmel\\CG9633 Elisa Kit
  • DmRPA Elisa Kit
  • dmrpa1 Elisa Kit
  • dRP-A Elisa Kit
  • HSSB Elisa Kit
  • i164 Elisa Kit
  • LOC100230990 Elisa Kit
  • MST075 Elisa Kit
  • Mt-SSB Elisa Kit
  • MtSSB Elisa Kit
  • REPA1 Elisa Kit
  • RF-A Elisa Kit
  • rp-a Elisa Kit
  • Rpa Elisa Kit
  • Rpa-70 Elisa Kit
  • RPA1 Elisa Kit
  • rpa70 Elisa Kit
  • RPA 70 Elisa Kit
  • RPA 70 kDa Elisa Kit
  • Ssb-70 Elisa Kit
  • Ssbp1 Elisa Kit
  • wu:fi14b08 Elisa Kit
  • zgc:55337 Elisa Kit
  • zgc:77092 Elisa Kit

Bezeichner auf Proteinebene für RPA1

CG9633-PA , RpA-70-PA , drosophila replication protein A , replication protein A 70 , single stranded-binding protein 70 , replication protein A1, 70kDa , replication protein A 70 kDa DNA-binding subunit , RF-A protein 1 , RP-A p70 , replication factor A protein 1 , replication protein A1 , replication protein A 70 kDa DNA-binding subunit-like , MSTP075 , single-stranded DNA-binding protein , replication protein A (RPA) , single-stranded DNA binding , single-stranded DNA-binding protein, mitochondrial

GENE ID SPEZIES
40972 Drosophila melanogaster
454414 Pan troglodytes
491196 Canis lupus familiaris
504844 Bos taurus
548449 Xenopus (Silurana) tropicalis
100230990 Taeniopygia guttata
100302100 Ovis aries
100341460 Oryctolagus cuniculus
100402829 Callithrix jacchus
100481495 Ailuropoda melanoleuca
100525428 Sus scrofa
100585556 Nomascus leucogenys
68275 Mus musculus
287524 Rattus norvegicus
327491 Danio rerio
6117 Homo sapiens
417563 Gallus gallus
397937 Xenopus laevis
100173266 Pongo abelii
100008866 Oryctolagus cuniculus
100298705 Bos taurus
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