anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antikörper

Bezeichnung:
anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Antikörper (RECQL2)
Auf www.antikoerper-online.de finden Sie aktuell 76 RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 80 RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Produkte verfügbar.
Synonyme:
AI846146, recq2, RECQ3, RECQL2, RECQL3, xBLM
Alle Antikörper anzeigen Gen GeneID UniProt
RECQL2 22427 O09053
RECQL2 7486 Q14191
RECQL2    

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Meistgesuchte Reaktivitäten zu anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antikörper

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anti-Human Antikörper:

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Am meisten referenzierte anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Antikörper

  1. Human Polyclonal RECQL2 Primary Antibody für ChIP, ICC - ABIN151918 : Harrigan, Piotrowski, Di Noto, Levine, Bohr: Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions. in The Journal of biological chemistry 2007 (PubMed)
    Zeige alle 9 Referenzen für 151918

  2. Human Polyclonal RECQL2 Primary Antibody für IHC (p), IP - ABIN151919 : Sidorova, Li, Folch, Monnat: The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Zeige alle 5 Referenzen für 151919

  3. Human Monoclonal RECQL2 Primary Antibody für IF, WB - ABIN394233 : Ehrenberg, Dratviman-Storobinsky, Avraham-Lubin, Goldenberg-Cohen: Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. in Molecular vision 2010 (PubMed)
    Zeige alle 5 Referenzen für 394233

  4. Human Polyclonal RECQL2 Primary Antibody für FACS, WB - ABIN656017 : Perry, Asaithamby, Barnebey, Kiamanesch, Chen, Han, Tainer, Yannone: Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. in The Journal of biological chemistry 2010 (PubMed)

  5. Human Monoclonal RECQL2 Primary Antibody für ICC, IF - ABIN2668372 : Opresko, Calvo, von Kobbe: Role for the Werner syndrome protein in the promotion of tumor cell growth. in Mechanisms of ageing and development 2007 (PubMed)

Weitere Antikörper gegen RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding Interaktionspartner

Mouse (Murine) RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Interaktionspartner

  1. A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress.

  2. The deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.

  3. Data suggest that, in the context of Wrn deficiency-related telomere dysfunction, loss of p16Ink4a (zeige CDKN2A Antikörper) function could prevent cells from senescence.

  4. The FEN1 (zeige FEN1 Antikörper) E359K germline mutation disrupts the FEN1 (zeige FEN1 Antikörper)-WRN interaction and FEN1 (zeige FEN1 Antikörper) GEN (zeige GEN1 Antikörper) activity, causing aneuploidy-associated cancers.

  5. Studies show that in the context of Myc-associated tumorigenesis, loss of Wrn amplifies the DNA damage response, both in preneoplastic and neoplastic tissue, engaging activation of tumor suppressor pathways.

  6. embryonic fibroblasts lacking a functional Wrn helicase (zeige DNA2 Antikörper) inhibited the immortalization of Safb1 (zeige SAFB Antikörper)-null cells. These results indicate that an intact Wrn protein is required for immortalization and tumorigenesis in Safb1 (zeige SAFB Antikörper)-null mice.

  7. BCR/ABL-mediated stimulation of WRN modulates the efficiency and fidelity of major DSB repair mechanisms to protect leukemia cells from apoptosis and to facilitate genomic instability.

  8. WRN has a role in processing specific types of homologous recombination intermediates as well as an important function in nonhomologous recombination

  9. results demonstrate that WRN loss confers a strong cellular phenotype in early passage human - though not mouse - primary fibroblasts.

  10. Genetic cooperation between this protein and poly(ADP-ribose) polymerase-1 (zeige PARP1 Antikörper) prevent chromatid breaks, complex chromosomal rearrangements, and cancer in mice.

Human RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Interaktionspartner

  1. Evaluation of localization of WRN signals demonstrated that WRN does not leave the nucleolus after irradiation. The WRN signal was not detected at the telomere sides, but H2AX was detected at the telomeric sides. Thus, the WRN protein is not involved in irradiation-induced DNA damage/repair, even at telomeric sides in human mesenchymal stem cells (hMSC) and hMSC-telomere 1.

  2. In humans, mutations in WRN give rise to Werner syndrome characterized by premature development of features associated with aging.

  3. Werner syndrome is a prototypical segmental progeroid syndrome characterized by multiple features consistent with accelerated aging. It is caused by null mutations of the WRN gene, which encodes a member of the RECQ family of DNA helicases.

  4. Our results identify the human WRN RECQ protein as a G4 helicase that modulates gene expression in G4-dependent fashion at many chromosomal sites and provide several new and unexpected mechanistic insights into Werner syndrome (WS) disease pathogenesis

  5. WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta (zeige POLD1 Antikörper) progression across telomeric G-rich repeats, only WRN promotes sequential strand displacement synthesis and FEN1 (zeige FEN1 Antikörper) cleavage.

  6. This study identified residues in the WRN RQC domain that are involved specifically in the interaction with G-quadruplex DNA.

  7. findings indicate that WRN interacts with HDACs 1 and 2 to facilitate activity of stalled replication forks under conditions of replication stress.

  8. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3 (zeige LAMC3 Antikörper)) with common associated variants.

  9. Finfings indicate a role for Werner syndrome helicase WRN as a modulator of DNA repair, replication, and recombination.

  10. The WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations. [meta-analysis]

RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Alternative names and synonyms associated with RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2)

  • RECQL2 (ARALYDRAFT_891126) Antikörper
  • Bloom syndrome, RecQ helicase-like (blm) Antikörper
  • Werner syndrome homolog (human) (Wrn) Antikörper
  • Werner syndrome, RecQ helicase-like (WRN) Antikörper
  • AI846146 Antikörper
  • recq2 Antikörper
  • RECQ3 Antikörper
  • RECQL2 Antikörper
  • RECQL3 Antikörper
  • xBLM Antikörper

Bezeichner auf Proteinebene für RECQL2

RECQL2 , Werner syndrome ATP-dependent helicase homolog , exonuclease WRN , DNA helicase, RecQ-like type 3 , Werner syndrome ATP-dependent helicase , recQ protein-like 2

GENE ID SPEZIES
9327212 Arabidopsis lyrata subsp. lyrata
100124311 Xenopus (Silurana) tropicalis
22427 Mus musculus
7486 Homo sapiens
Ausgewählte Anbieter für anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) Antikörper
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