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Human PRKDC Protein expressed in Wheat germ - ABIN1316293
Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. in Cell death & disease 2013
This study showed that the levels of CD44 (zeige CD44 Proteine) and DNA-PK are associated with a better survival and better response to radiotherapy and temozolomide.
this study suggests that improved anti-proliferative and cytotoxic effects of Ag-np treatment in cancer cells can be achieved by the inhibition of DNA-PKcs.
this study has solved the PRKDC structure in complex with the C-terminal peptide of Ku80 (zeige XRCC5 Proteine) at 4.3 angstrom resolution using x-ray crystallography.
DNA-PKcs, which is integral to the non-homologous end joining pathway, negatively regulates ATM (zeige ATM Proteine) activity through phosphorylation of ATM (zeige ATM Proteine).
that EZH2 (zeige EZH2 Proteine) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.
DNA-PKcs is a potent regulator of IL-2 (zeige IL2 Proteine) production in T lymphocytes.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PK directly phosphorylates hSSB1 (zeige SSBP1 Proteine) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.
Data suggest that the model can replicate amplified p53 (zeige TP53 Proteine) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (zeige TP53 Proteine) dynamics.
Ku80 (zeige XRCC5 Proteine) is susceptible to proteolytic degradation when not dimerized with Ku70 (zeige XRCC6 Proteine); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
DNA-PKcs deficiency caused inefficient DSB repair at later time points post-IR in both conditions. These observations suggest that DNA-PKcs contributes to the fast and slow repair of DSBs by NHEJ.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (zeige H2AFX Proteine) formation, and failure to remove H2BK120ub inhibits ATM (zeige ATM Proteine)- and DNAPK-induced gammaH2AX (zeige H2AFX Proteine) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (zeige AIM2 Proteine) reduced Akt (zeige AKT1 Proteine) activation and tumor burden in colorectal cancer models, while an Akt (zeige AKT1 Proteine) inhibitor reduced tumor load in Aim2 (zeige AIM2 Proteine)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (zeige TRIP13 Proteine) binding partners in head and neck cancer.
NR5A1 (zeige NR5A1 Proteine) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (zeige CTNNB1 Proteine) accumulation
Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
DNA-PK catalytic subunit
, DNA-dependent protein kinase catalytic subunit
, hyper-radiosensitivity of murine scid mutation, complementing 1
, protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, doxorubicin nephropathy
, severe combined immunodeficiency