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The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (zeige H2AFX ELISA Kits) formation, and failure to remove H2BK120ub inhibits ATM (zeige ATM ELISA Kits)- and DNAPK-induced gammaH2AX (zeige H2AFX ELISA Kits) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (zeige AIM2 ELISA Kits) reduced Akt (zeige AKT1 ELISA Kits) activation and tumor burden in colorectal cancer models, while an Akt (zeige AKT1 ELISA Kits) inhibitor reduced tumor load in Aim2 (zeige AIM2 ELISA Kits)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (zeige TRIP13 ELISA Kits) binding partners in head and neck cancer.
NR5A1 (zeige NR5A1 ELISA Kits) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (zeige CTNNB1 ELISA Kits) accumulation
Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.
These experiments define a novel requirement for 53BP1 (zeige TP53BP1 ELISA Kits) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.
data suggest that DNA-PKcs-SIN1 (zeige MAPKAP1 ELISA Kits) complexation-mediated Akt (zeige AKT1 ELISA Kits) activation (Ser (zeige SIGLEC1 ELISA Kits)-473 phosphorylation) is required for mouse osteoblast differentiation
this study has solved the PRKDC structure in complex with the C-terminal peptide of Ku80 (zeige XRCC5 ELISA Kits) at 4.3 angstrom resolution using x-ray crystallography.
DNA-PKcs, which is integral to the non-homologous end joining pathway, negatively regulates ATM (zeige ATM ELISA Kits) activity through phosphorylation of ATM (zeige ATM ELISA Kits).
that EZH2 (zeige EZH2 ELISA Kits) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.
DNA-PKcs is a potent regulator of IL-2 (zeige IL2 ELISA Kits) production in T lymphocytes.
DNA-PK directly phosphorylates hSSB1 (zeige SSBP1 ELISA Kits) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.
Data suggest that the model can replicate amplified p53 (zeige TP53 ELISA Kits) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (zeige TP53 ELISA Kits) dynamics.
These studies clarify the role of PKCdelta (zeige PKCd ELISA Kits) in endothelial cell cytoskeleton regulation.
T204 was identified as a main target for ATM (zeige ATM ELISA Kits)/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.
Ku80 (zeige XRCC5 ELISA Kits) is susceptible to proteolytic degradation when not dimerized with Ku70 (zeige XRCC6 ELISA Kits); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-dependent protein kinase catalytic subunit
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, DNA-PK catalytic subunit
, doxorubicin nephropathy
, severe combined immunodeficiency
, hyper-radiosensitivity of murine scid mutation, complementing 1