anti-PRKDC (PRKDC) Antikörper

Bezeichnung:
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide Antikörper (PRKDC)
Auf www.antikoerper-online.de finden Sie aktuell 412 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Antikörper von 27 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PRKDC Kits (9) und PRKDC Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 437 PRKDC Produkte verfügbar.
Synonyme:
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
Alle Antikörper anzeigen Gen GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527
PRKDC    

Alle Spezies anzeigen

Weitere Synonyme anzeigen

Alle verfügbaren anti-PRKDC Antikörper

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Am meisten referenzierte anti-PRKDC Antikörper

  1. Human Polyclonal PRKDC Primary Antibody für EIA - ABIN358415 : Goudelock, Jiang, Pereira, Russell, Sanchez: Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 5 Referenzen für 358415

  2. Human Polyclonal PRKDC Primary Antibody für IP, ELISA - ABIN129603 : Dittmann, Mayer, Wanner, Kehlbach, Rodemann: The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007 (PubMed)
    Zeige alle 5 Referenzen für 129603

  3. Human Monoclonal PRKDC Primary Antibody für IF, IHC (p) - ABIN197619 : Carter, Vancurová, Sun, Lou, DeLeon: A DNA-activated protein kinase from HeLa cell nuclei. in Molecular and cellular biology 1991 (PubMed)
    Zeige alle 5 Referenzen für 197619

  4. Human Monoclonal PRKDC Primary Antibody für IF, IP - ABIN197617 : Han, Malik, Carter, Reeves, Wyche, Hendrickson: DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. in The Journal of biological chemistry 1996 (PubMed)
    Zeige alle 5 Referenzen für 197617

  5. Human Monoclonal PRKDC Primary Antibody für IF, IP - ABIN968186 : Araki, Fujimori, Hamatani, Mita, Saito, Mori, Fukumura, Morimyo, Muto, Itoh, Tatsumi, Abe: Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Zeige alle 4 Referenzen für 968186

  6. Human Polyclonal PRKDC Primary Antibody für WB - ABIN196898 : Ding, Reddy, Wang, Woods, Douglas, Ramsden, Lees-Miller, Meek: Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. in Molecular and cellular biology 2003 (PubMed)
    Zeige alle 3 Referenzen für 196898

  7. Human Polyclonal PRKDC Primary Antibody für WB - ABIN197394 : Chan, Chen, Prithivirajsingh, Kurimasa, Story, Qin, Chen: Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. in Genes & development 2002 (PubMed)
    Zeige alle 3 Referenzen für 197394

  8. Human Monoclonal PRKDC Primary Antibody für ELISA, ICC - ABIN4305550 : Fantini, Huang, Asara, Bagchi, Raychaudhuri: Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. in Molecular biology of the cell 2016 (PubMed)

  9. Human Monoclonal PRKDC Primary Antibody für IF, IHC - ABIN269396 : Shamanna, Hoque, Lewis-Antes, Azzam, Lagunoff, Peery, Mathews: The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. in Molecular and cellular biology 2011 (PubMed)

Weitere Antikörper gegen PRKDC Interaktionspartner

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Interaktionspartner

  1. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  2. DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.

  3. AIM2 (zeige AIM2 Antikörper) reduced Akt (zeige AKT1 Antikörper) activation and tumor burden in colorectal cancer models, while an Akt (zeige AKT1 Antikörper) inhibitor reduced tumor load in Aim2 (zeige AIM2 Antikörper)(-/-) mice

  4. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (zeige TRIP13 Antikörper) binding partners in head and neck cancer.

  5. NR5A1 (zeige NR5A1 Antikörper) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (zeige CTNNB1 Antikörper) accumulation

  6. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  7. These experiments define a novel requirement for 53BP1 (zeige TP53BP1 Antikörper) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  8. data suggest that DNA-PKcs-SIN1 (zeige MAPKAP1 Antikörper) complexation-mediated Akt (zeige AKT1 Antikörper) activation (Ser (zeige SIGLEC1 Antikörper)-473 phosphorylation) is required for mouse osteoblast differentiation

  9. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  10. DNA-PK and ATM (zeige ATM Antikörper) acts in parallel upstream of XRCC4 (zeige XRCC4 Antikörper), regulating through phosphorylation

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Interaktionspartner

  1. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  2. DNA-PK directly phosphorylates hSSB1 (zeige SSBP1 Antikörper) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.

  3. DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen (zeige KLK3 Antikörper) relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

  4. Data suggest that the model can replicate amplified p53 (zeige TP53 Antikörper) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (zeige TP53 Antikörper) dynamics.

  5. These studies clarify the role of PKCdelta (zeige PKCd Antikörper) in endothelial cell cytoskeleton regulation.

  6. T204 was identified as a main target for ATM (zeige ATM Antikörper)/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  7. DNA-PKcs inhibitor acriflavine exerts a p53 (zeige TP53 Antikörper)-dependent synergistic efficacy with melphalan against human cancer cells both in vitro and in vivo.

  8. EBV-LMP1 (zeige PDLIM7 Antikörper) suppresses the DNA damage response through DNA-PK/AMPK (zeige PRKAA1 Antikörper) signaling to promote radioresistance in nasopharyngeal carcinoma.

  9. Together, our results provide evidence that acetylation potentially regulates DNA-PKcs.

  10. Inhibiting PRKDC radiosensitizes human osteosarcoma cells.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) Interaktionspartner

  1. Ku80 (zeige XRCC5 Antikörper) is susceptible to proteolytic degradation when not dimerized with Ku70 (zeige XRCC6 Antikörper); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen-Profil

Beschreibung des Gens

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) Antikörper
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) Antikörper
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) Antikörper
  • AI326420 Antikörper
  • AU019811 Antikörper
  • DNA-PKCS Antikörper
  • DNAPDcs Antikörper
  • dnapk Antikörper
  • dnpk1 Antikörper
  • DOXNPH Antikörper
  • dxnph Antikörper
  • hyrc Antikörper
  • hyrc1 Antikörper
  • p350 Antikörper
  • p460 Antikörper
  • PRKDC Antikörper
  • prkdc-A Antikörper
  • scid Antikörper
  • slip Antikörper
  • xrcc7 Antikörper

Bezeichner auf Proteinebene für PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

GENE ID SPEZIES
282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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