anti-POLL (POLL) Antikörper

Bezeichnung:
anti-Polymerase (DNA Directed), lambda Antikörper (POLL)
Auf www.antikoerper-online.de finden Sie aktuell 62 Polymerase (DNA Directed), lambda (POLL) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen POLL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 73 POLL Produkte verfügbar.
Synonyme:
1110003P06Rik, AV007317, beta-n, BETAN, pol-kappa, POLKAPPA, T10O24.13, T10O24_13, wu:fe49a04, zgc:66320, zgc:77901

Meistgesuchte Reaktivitäten zu anti-POLL (POLL) Antikörper

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anti-Human POLL Antikörper:

anti-Mouse (Murine) POLL Antikörper:

anti-Rat (Rattus) POLL Antikörper:

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Am meisten referenzierte anti-POLL Antikörper

  1. Human Polyclonal POLL Primary Antibody für EIA, WB - ABIN951932 : Brown, Fiala, Fowler, Sherrer, Newmister, Duym, Suo: A novel mechanism of sugar selection utilized by a human X-family DNA polymerase. in Journal of molecular biology 2010 (PubMed)
    Zeige alle 3 Referenzen für 951932

  2. Cow (Bovine) Polyclonal POLL Primary Antibody für WB - ABIN2785955 : Picher, Blanco: Human DNA polymerase lambda is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. in DNA repair 2007 (PubMed)

  3. Human Polyclonal POLL Primary Antibody für IHC (p), IHC - ABIN250110 : García-Díaz, Bebenek, Sabariegos, Domínguez, Rodríguez, Kirchhoff, García-Palomero, Picher, Juárez, Ruiz, Kunkel, Blanco: DNA polymerase lambda, a novel DNA repair enzyme in human cells. in The Journal of biological chemistry 2002 (PubMed)

Weitere Antikörper gegen POLL Interaktionspartner

Arabidopsis thaliana Polymerase (DNA Directed), lambda (POLL) Interaktionspartner

  1. DNA Pol lambda recognizes 8-Oxo-G on a template as a normal guanine and preferentially incorporates dCTP over dATP opposite this lesion.

Human Polymerase (DNA Directed), lambda (POLL) Interaktionspartner

  1. T204 was identified as a main target for ATM (zeige ATM Antikörper)/DNA-PKcs (zeige PRKDC Antikörper) phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  2. The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn (zeige FYN Antikörper)-conformation. Importantly, we show that discrimination against the pro-mutagenic syn (zeige FYN Antikörper)-conformation occurs at the extension step and identify the residue responsible for this selectivity.

  3. Pol beta (zeige POLB Antikörper), to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.

  4. Fen1 (zeige FEN1 Antikörper) significantly stimulated trinucleotide repeats expansion by Pol beta (zeige POLB Antikörper), but not by the related enzyme Pol lambda.

  5. DNA polymerase (zeige POLB Antikörper) lamda catalyzes lesion bypass across benzo[a]pyrene-derived DNA adducts.

  6. pol lambda is responsible for a significant fraction of Fapy.dG-induced G --> T mutations.

  7. Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda.

  8. A specific N-terminal extension of the 8 kDa domain of DNA polymerase lambda is important for the non-homologous end joining function.

  9. Inactivation of polymerase (DNA directed) lambda lyase activity by 5'-(2-phosphoryl-1,4-dioxobutane prevents the enzyme from conducting polymerization following preincubation of the protein and DNA.

  10. The results provides evidence that DNA pol lambda is required for cell cycle progression and is functionally connected to the S phase DNA damage response machinery in cancer cells.

Mouse (Murine) Polymerase (DNA Directed), lambda (POLL) Interaktionspartner

  1. Pol mu (zeige POLM Antikörper) and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair

  2. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (zeige CNTNAP1 Antikörper)) with no effect on mutation specificity, suggesting no direct role in SHM (zeige CNTNAP1 Antikörper).

  3. both pol lambda and pol beta (zeige POLB Antikörper) interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases

  4. analysis of the interaction between DNA Polymerase lambda and anticancer nucleoside analogs

  5. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.

  6. Pol lambda is not required for normal Ig gene hypermutation.

  7. Pol lambda contributes to base excision repair in mouse fibroblast cell extract.

  8. Pol lambda protects cells against oxidative stress, and participates in oxidative DNA damage base excision repair.

  9. third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu (zeige POLM Antikörper) ensuring a restricted light chain junctional variability

POLL Antigen-Profil

Beschreibung des Gens

This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with POLL

  • DNA polymerase lambda subunit (AT1G10520) Antikörper
  • DNA polymerase lambda (PTRG_00468) Antikörper
  • polymerase (DNA directed), lambda (poll) Antikörper
  • polymerase (DNA directed), lambda (POLL) Antikörper
  • DNA polymerase lambda (MCYG_03796) Antikörper
  • DNA polymerase lambda (ARALYDRAFT_312091) Antikörper
  • DNA polymerase lambda (MGYG_02138) Antikörper
  • polymerase (DNA directed), lambda (Poll) Antikörper
  • 1110003P06Rik Antikörper
  • AV007317 Antikörper
  • beta-n Antikörper
  • BETAN Antikörper
  • pol-kappa Antikörper
  • POLKAPPA Antikörper
  • T10O24.13 Antikörper
  • T10O24_13 Antikörper
  • wu:fe49a04 Antikörper
  • zgc:66320 Antikörper
  • zgc:77901 Antikörper

Bezeichner auf Proteinebene für POLL

DNA polymerase lambda , DNA-directed DNA polymerase lambda , polymerase (DNA directed), lambda , DNA polymerase lambda-like , DNA polymerase beta-2 , DNA polymerase beta-N , DNA polymerase kappa , pol Lambda

GENE ID SPEZIES
837592 Arabidopsis thaliana
6339420 Pyrenophora tritici-repentis Pt-1C-BFP
406697 Danio rerio
450687 Pan troglodytes
711924 Macaca mulatta
9229614 Arthroderma otae CBS 113480
9325878 Arabidopsis lyrata subsp. lyrata
10029906 Arthroderma gypseum CBS 118893
100101731 Xenopus (Silurana) tropicalis
100458210 Pongo abelii
100471165 Ailuropoda melanoleuca
100583874 Nomascus leucogenys
27343 Homo sapiens
56626 Mus musculus
608341 Canis lupus familiaris
361767 Rattus norvegicus
423853 Gallus gallus
100153781 Sus scrofa
522307 Bos taurus
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