anti-Polymerase (DNA Directed), eta (POLH) Antikörper

anti-Polymerase (DNA Directed), eta Antikörper (POLH)
Auf finden Sie aktuell 54 Polymerase (DNA Directed), eta (POLH) Antikörper von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Polymerase (DNA Directed), eta Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 62 Polymerase (DNA Directed), eta Produkte verfügbar.
fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642

Meistgesuchte Reaktivitäten zu anti-Polymerase (DNA Directed), eta (POLH) Antikörper

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Am meisten referenzierte anti-Polymerase (DNA Directed), eta Antikörper

  1. Human Polyclonal POLH Primary Antibody für WB - ABIN1882183 : Glick, Vigna, Loeb: Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. in The EMBO journal 2001 (PubMed)
    Zeige alle 5 Referenzen für 1882183

  2. Human Polyclonal POLH Primary Antibody für IP, WB - ABIN253042 : Day, Palle, Barkley, Kakusho, Zou, Tateishi, Verreault, Masai, Vaziri: Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication. in The Journal of cell biology 2010 (PubMed)
    Zeige alle 2 Referenzen für 253042

  3. Yeast (Saccharomyces cerevisiae) Polyclonal POLH Primary Antibody für WB - ABIN493404 : Parker, Bielen, Dikic, Ulrich: Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. in Nucleic acids research 2007 (PubMed)
    Zeige alle 2 Referenzen für 493404

Weitere Antikörper gegen Polymerase (DNA Directed), eta Interaktionspartner

Xenopus laevis Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. Error-free insertion in cyclobutane pyrimidine bypass is due mainly to pol eta (translesion synthesis TLS3) in oocyte extracts during DNA replication.

Human Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. The current work explores both the fidelity of DNA polymerase eta and the role of the 3rd metal ion (magnesium), by using empirical valence bond simulations.

  2. The results suggest that translesion synthesis by Pol eta can contribute to the accumulation of rCMP in the genome, particularly opposite modified guanines.

  3. the targeting of Poleta to damage sites after UV exposure is regulated by SPARTAN, and this function contributes highly to its DNA-damage tolerance function.

  4. Study shows that the posttranslational modifications of nuclear localization signal of pol eta played a dual role in polymerase switching, where Lys682 deubiquitination promotes the recruitment of pol eta to PCNA (zeige PCNA Antikörper) immediately prior to lesion bypass and Ser687 phosphorylation stimulates its departure from the replication fork immediately after lesion bypass.

  5. The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase.

  6. p53 (zeige TP53 Antikörper) controls the induction of DNA polymerase eta in DNA damaged human cells. The role of DNA polymerase eta in p53 (zeige TP53 Antikörper)-dependent translesion synthesis.

  7. These results provide important knowledge about the effects of the length and structure of the alkyl group in O(4)-alkylthymidine lesions on the fidelity and efficiency of DNA replication mediated by human DNA polymerase eta.

  8. The described is cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase eta.

  9. free energy difference is slightly greater for binding at the 5' thymine position than at the 3' thymine position, presumably because of stabilization arising from the A:T base pair formed at the 3' position of the TTD in previous step of Pol eta function

  10. PolH721 variant present in XP-V patients is unstable. Extra 8 amino acids of PolH721 do not act as degron but induce conformational change of PolH C-terminus exposing its bipartite NLS and sequence close to its UBZ to the ubiquitin/proteasome system.

Mouse (Murine) Polymerase (DNA Directed), eta (POLH) Interaktionspartner

  1. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta.

  2. XP-V has a role in adipose tissue senescence and metabolic syndrome

  3. Increase in UV-induced mutations at both G:C and A:T pairs associated with PolH deficiency suggests that PolH contributes to accurate translesion synthesis (TLS (zeige FUS Antikörper)) past both T- & C-containing dimers.

  4. POLH deficiency did not affect the frequency and patterns of C:G mutations and UNG (zeige UNG Antikörper) POLH double deficiency showed an additive effect of single deficiency.

  5. REV1 and Polkappa are involved in DNA damage tolerance via Poleta-REV1 interaction when Poleta fails to bypass its cognate substrates.

  6. These results reveal genetic interactions between REV1 catalytic activity and POLH and identify an alternative pathway in the generation of C to G and G to C transversions.

  7. these data support the existence of PCNA (zeige PCNA Antikörper) ubiquitination-dependent and -independent activation pathways of Poleta during somatic hypermutation and DNA damage tolerance.

  8. inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hypermutation (SHM (zeige CNTNAP1 Antikörper)) of Ig genes

  9. suggest the involvement of the Pol eta and Pol iota (zeige POLI Antikörper) proteins in UV-induced skin carcinogenesis

  10. Results reveal genetic and biochemical interactions between DNA polymerases eta (POLH) and theta (POLQ (zeige POLQ Antikörper)) and suggest that POLQ (zeige POLQ Antikörper) might cooperate with POLH to generate some of the A/T mutations during the somatic hypermutation of Ig genes.

Polymerase (DNA Directed), eta (POLH) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.

Alternative names and synonyms associated with Polymerase (DNA Directed), eta (POLH)

  • polymerase (DNA directed), eta (polh) Antikörper
  • polymerase (DNA directed), eta (POLH) Antikörper
  • DNA polymerase eta (Tb10.70.6190) Antikörper
  • DNA polymerase eta (LinJ21.0530) Antikörper
  • polymerase (DNA directed), eta (Polh) Antikörper
  • polymerase (DNA directed), eta (RAD 30 related) (Polh) Antikörper
  • fc50a12 Antikörper
  • POLH Antikörper
  • RAD30 Antikörper
  • RAD30A Antikörper
  • wu:fc50a12 Antikörper
  • XP-V Antikörper
  • XPV Antikörper
  • zgc:136881 Antikörper
  • zgc:152642 Antikörper

Bezeichner auf Proteinebene für POLH

DNA-directed DNA polymerase eta , DNA polymerase eta , polymerase (DNA directed), eta , DNA polymerase eta-like , polymerase eta , RAD30 homolog A , xeroderma pigmentosum variant type protein , polymerase (DNA directed), eta (RAD 30 related) , xeroderma pigmentosum variant type protein homolog

446909 Xenopus laevis
462720 Pan troglodytes
474915 Canis lupus familiaris
513606 Bos taurus
678520 Danio rerio
700772 Macaca mulatta
3661974 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5068792 Leishmania infantum JPCM5
100011953 Monodelphis domestica
100067518 Equus caballus
100124112 Nasonia vitripennis
100357494 Oryctolagus cuniculus
100392158 Callithrix jacchus
100443019 Pongo abelii
100473341 Ailuropoda melanoleuca
395102 Gallus gallus
100558919 Anolis carolinensis
100602084 Nomascus leucogenys
5429 Homo sapiens
316235 Rattus norvegicus
80905 Mus musculus
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