anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antikörper

Bezeichnung:
anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit Antikörper (POLD3)
Auf www.antikoerper-online.de finden Sie aktuell 42 Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antikörper von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 49 Polymerase (DNA-Directed), delta 3, Accessory Subunit Produkte verfügbar.
Synonyme:
2410142G14Rik, C85233, P66, P68, zgc:136471
Alle Antikörper anzeigen Gen GeneID UniProt
POLD3 10714 Q15054
POLD3 67967  
POLD3 293144  

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Am meisten referenzierte anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit Antikörper

  1. Human Polyclonal POLD3 Primary Antibody für EIA, WB - ABIN954235 : Baranovskiy, Babayeva, Liston, Rogozin, Koonin, Pavlov, Vassylyev, Tahirov: X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Zeige alle 4 Referenzen für 954235

  2. Human Monoclonal POLD3 Primary Antibody für IF, ELISA - ABIN564666 : Bursomanno, Beli, Khan, Minocherhomji, Wagner, Bekker-Jensen, Mailand, Choudhary, Hickson, Liu: Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. in DNA repair 2014 (PubMed)

Weitere Antikörper gegen Polymerase (DNA-Directed), delta 3, Accessory Subunit Interaktionspartner

Human Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Interaktionspartner

  1. Studies indicate that DNA polymerase delta 3 (Pol delta3) exhibits significant differences in properties with a major impact on cellular processes in genomic surveillance, DNA replication and DNA repair.

  2. Data suggest that relatively high affinity binding of PolD3-RIR (zeige APBB1 Antikörper) motif to Rev1 (zeige REV1 Antikörper)-C-terminal domain displaces subunits from PolN, Pol-iota (zeige POLM Antikörper), or PolK (zeige PAPD7 Antikörper) from Rev1 (zeige REV1 Antikörper) complex and promotes formation of Rev1 (zeige REV1 Antikörper)/PolZ4 assembly with PCNA (zeige PCNA Antikörper) for translesion DNA replication.

  3. POLD3 is SUMOylated by SUMO2 (zeige SUMO2 Antikörper) in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress.

  4. Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.

  5. In a cyclin E (zeige CCNE1 Antikörper) overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.

  6. Pol delta3 is the predominant form of Pol delta (zeige POLD1 Antikörper) at sites of UV damage as a result of p12 (zeige POLE4 Antikörper) degradation; results show that Pol delta (zeige POLD1 Antikörper) at the DNA damage site is the Pol delta (zeige POLD1 Antikörper) trimer lacking p12 (zeige POLE4 Antikörper) regardless of the cell cycle phase

  7. We identified three new CRC (zeige CALR Antikörper) risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2 (zeige SHROOM2 Antikörper); P = 7.30 x 10(-10)).

  8. Serine-458, located in the proliferating cell nuclear antigen (PCNA (zeige PCNA Antikörper))-interacting motif of Poldelta(p68 (zeige ANXA6 Antikörper)), is a phosphorylation site for protein kinase A (PKA); p68 (zeige ANXA6 Antikörper) mutation results in decreased p68 (zeige ANXA6 Antikörper) affinity for PCNA (zeige PCNA Antikörper) as well as processivity of Poldelta.

  9. show that there is a direct interaction between p66 and PCNA (zeige PCNA Antikörper) in living cells during DNA replication. The dominant negative effect upon growth resulting from expression of p66 sub-domains confirms that the p66-PCNA (zeige PCNA Antikörper) interaction is essential in vivo.

  10. POLD3, plays a crucial role in the efficient recycling of PCNA (zeige PCNA Antikörper) during dissociation-association cycles of pol delta (zeige POLD1 Antikörper) during elongation phase of DNA replication.

Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antigen-Profil

Beschreibung des Gens

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3)

  • polymerase (DNA-directed), delta 3, accessory subunit (pold3) Antikörper
  • polymerase (DNA-directed), delta 3, accessory subunit (LOC100221313) Antikörper
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3) Antikörper
  • polymerase (DNA-directed), delta 3, accessory subunit (Pold3) Antikörper
  • 2410142G14Rik Antikörper
  • C85233 Antikörper
  • P66 Antikörper
  • P68 Antikörper
  • zgc:136471 Antikörper

Bezeichner auf Proteinebene für POLD3

DNA-directed DNA polymerase delta 3 , DNA polymerase delta p66 subunit , DNA polymerase delta subunit 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA polymerase delta subunit 3-like , DNA polymerase delta subunit p66 , Pol delta C subunit (p66) , GC12 , polymerase (DNA directed), delta 3

GENE ID SPEZIES
398707 Xenopus laevis
692256 Danio rerio
100221313 Taeniopygia guttata
100357626 Oryctolagus cuniculus
100403947 Callithrix jacchus
100435558 Pongo abelii
100471417 Ailuropoda melanoleuca
100602450 Nomascus leucogenys
10714 Homo sapiens
67967 Mus musculus
293144 Rattus norvegicus
537616 Bos taurus
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