NTH1 (NTHL1) ELISA Kits

Bezeichnung:
NTH1 ELISA Kits (NTHL1)
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Synonyme:
NTH1, OCTS3
list all ELISA KIts Gen GeneID UniProt
Maus NTHL1 NTHL1 18207  
Ratte NTHL1 NTHL1 29541  
Human NTHL1 NTHL1 4913 P78549

Weitere Synonyme anzeigen

Weitere ELISA Kits für NTH1 Interaktionspartner

Mouse (Murine) NTH1 (NTHL1) Interaktionspartner

  1. Toxicity, induced by tert (zeige TERT ELISA Kits)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (zeige MPG ELISA Kits) (+/+), Nth1 (+/+)) and deficient (Mpg (zeige MPG ELISA Kits) (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 (zeige MSH2 ELISA Kits) knockdown, was examined.

  2. These results suggest that Nth1 plays an important role in telomere maintenance and base repair against oxidative stress-induced (zeige SQSTM1 ELISA Kits) base modifications.

  3. deficiencies in Ogg1 (zeige OGG1 ELISA Kits) and/or Nth1 do not lead to decreased DNA double strand breaks

  4. To determine the significance of thymine glycol repair in mammals, a mouse model with mutated mNth1, a homolog of nth (zeige APEX1 ELISA Kits), was made by gene targeting. Mutant mouse liver, instead of mNTH1 activity, had at least 2 novel DNA glycosylase activities against Tg.

  5. To determine the role of murine Nth1 in protecting genomic integrity, a knockout strain was created. No phenotypic changes from wild type were noted due to a novel AP endonuclease DNA repair system.

  6. NEIL1 (zeige NEIL1 ELISA Kits) is a back-up glycosylase for NTH1 with unique substrate specificity and tissue-specific expression

  7. ability of nth1 to discriminate between thymine glycol stereoisomers

  8. results indicated that 8-oxoguanine DNA-glycosylase (OGG1 (zeige OGG1 ELISA Kits)) and nth (endonuclease III)-like 1(NTH1) are the major DNA glycosylases for the removal of 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA)

  9. The high incidence of tumors in Nth1-/-Neil1 (zeige NEIL1 ELISA Kits)-/- mice together with the activating mutation in the K-ras (zeige HRAS ELISA Kits) gene of their pulmonary tumors, reveal for the first time, the existence of mutagenic and carcinogenic oxidative damage to DNA which is not 8-OH-Gua (zeige DDX21 ELISA Kits).

Human NTH1 (NTHL1) Interaktionspartner

  1. WT NTHL1 (human) and Nth (zeige APEX1 ELISA Kits) (E. coli) are remarkably alike with respect to specificity of glycosylase reaction, and although NTHL1 is a much slower enzyme than Nth (zeige APEX1 ELISA Kits), the tighter binding of NTHL1 compensates, resulting in similar kcat/Kd values for both enzymes with each of the substrates tested. For NTHL1 Gln287Ala, specificity for substrates positioned opposite G is lost, but not that of substrates positioned opposite A.

  2. We therefore found published evidence to support the association between variants in NTHL1 and RPS20 (zeige RPS20 ELISA Kits) with CRC (zeige CALR ELISA Kits).

  3. Both Ntg1 and its human homologue, NTHL1, can be SUMO-modified in response to oxidative stress.

  4. NTH1 polymorphisms may be associated with non-small cell lung cancer pathogenesis.

  5. This study extends the description of biallelic mutations in NTHL1 beyond the single c.268C-->T,p.Q90* mutation that was observed previously.

  6. A homozygous loss-of-function germline mutation in the NTHL1 gene predisposes to a new subtype of BER-associated adenomatous polyposis and colorectal cancer.

  7. NTH1 is involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA

  8. substrate selectivity of mammalian NTH1 and the concomitant selective stimulation of activity by APE1 (zeige APEX1 ELISA Kits) are indicative of selective repair of oxidative damage in different regions of the genome

  9. search for the factors interacting with NTH1 shows GST-NTH1 fusion protein precipitates proliferating cell nuclear antigen (PCNA (zeige PCNA ELISA Kits)) and p53 (zeige TP53 ELISA Kits) as well as XPG (zeige ERCC5 ELISA Kits) from human cell-free extracts

  10. NTH1 is a DNA glycosylase that excise 5-formyluracil, 5-hydroxymethyluracil and Thymine glycol in human cells.

NTH1 (NTHL1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.

Alternative names and synonyms associated with NTH1 (NTHL1)

  • nth (endonuclease III)-like 1 (E.coli) (Nthl1) Elisa Kit
  • nth endonuclease III-like 1 (E. coli) (NTHL1) Elisa Kit
  • NTH1 Elisa Kit
  • OCTS3 Elisa Kit

Bezeichner auf Proteinebene für NTH1 (NTHL1) ELISA Kits

endonuclease III-like protein 1 , thymine glycol DNA glycosylase/AP lyase , nth endonuclease III-like 1

GENE ID SPEZIES
18207 Mus musculus
29541 Rattus norvegicus
4913 Homo sapiens
535203 Bos taurus
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