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Data indicate that DNA glycosylases MYH (zeige MUTYH Proteine), UNG2 (zeige CCNO Proteine), MPG (zeige MPG Proteine), NTH1, NEIL1, 2 and 3 on nascent DNA.
identified the c-Jun N-terminal kinase 1 (JNK1 (zeige MAPK8 Proteine)) as the kinase involved in the phosphorylation of NEIL1
NEIL1 (rs5745908) is associated with Behcet's disease. The genetic association in NEIL1 is a predicted splice donor variant that may introduce a deleterious intron retention and result in a noncoding transcript variant.
cellular NEIL1 is regulated by the UPP (zeige UPP1 Proteine) mediated by the E3 ubiquitin ligases Mule (zeige HUWE1 Proteine) and TRIM26 (zeige TRIM26 Proteine), which plays a vital role in co-ordinating the cellular response to DNA damage.
Nei (zeige PMCH Proteine) Like DNA Glycosylase 1 (NEIL1) as a likely candidate gene due to its crucial role in B-cell activation (zeige BLNK Proteine) and terminal differentiation.
The abnormal expressions of NEIL1, NEIL2 (zeige NEIL2 Proteine), and NEIL3 (zeige NEIL3 Proteine) are involved in cancer through their association with the somatic mutation load.
NEIL1 and NEIL2 (zeige NEIL2 Proteine) cooperate with TDG (zeige TDG Proteine) during base excision: TDG (zeige TDG Proteine) occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG (zeige TDG Proteine)-substrate turnover.
Findings suggesting that DNA glycosylase NEIL1 c.C844T is a defective allele.
NEIL1 forms a multiprotein complex with DNA replication proteins via its C-terminal domain, allowing recruitment at the replication fork.
Results show that YB-1 (zeige YBX1 Proteine) interferes negatively with the AP site DNA cleavage activity of both APE1 (zeige APEX1 Proteine) and NEIL1 for ssDNA and bubble structures.
Collectively the data suggest that NEIL1-initiated repair of a subset of ROS (zeige ROS1 Proteine)-induced DNA base lesions may be insufficient to prevent the initiation of inflammatory pathways during chronic UV exposure in mouse skin.
Rad9 (zeige RAD9A Proteine) regulates base excision repair by controlling Neil1 protein stability in mouse embryonic stem cells.
Hypersensitivity to H2O2 caused by NEIL1 knockdown was more significant in S phase than in G1 phase, suggesting that NEIL1 has an important role during S phase.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (zeige OGG1 Proteine), Neil1, Mutyh (zeige MUTYH Proteine) and Xrcc1 (zeige XRCC1 Proteine) in the brain of adult offspring.
one role for Neil3 (zeige NEIL3 Proteine) and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 (zeige NEIL3 Proteine) and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
binds to the BRCT domain of PARP-1 (zeige PARP1 Proteine)
Neil1 contributes to germline and somatic Huntington's disease CAG repeat (zeige CELF3 Proteine) expansion.
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.
NEIL1 deficiency results in an increased susceptibility to obesity and related complications potentially by lowering the threshold for tolerance of cellular oxidative stress in neil1(-/-) mice.
NEIL1 is involved in nucleotide excision repair of(5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines, in addition to its function as a DNA glycosylase in base excision repair.
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
endonuclease VIII-like 1
, DNA glycosylase/AP lyase Neil1
, DNA-(apurinic or apyrimidinic site) lyase Neil1
, endonuclease 8-like 1
, endonuclease VIII
, nei homolog 1
, nei-like protein 1