MUS81 Proteine (MUS81)

Bezeichnung:
MUS81 Endonuclease Homolog (S. Cerevisiae) Proteine (MUS81)
Auf www.antikoerper-online.de finden Sie aktuell 6 MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MUS81 Antikörper (41) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 51 MUS81 Produkte verfügbar.
Synonyme:
1200008A18Rik, AI182501, ARABIDOPSIS THALIANA MMS AND UV SENSITIVE 81, ATMUS81, AW045863, CG3026, Dmel\\CG3026, EG:BACR7A4.16, F6I18.220, F6I18_220, GB15332, MMS AND UV SENSITIVE 81, MUS81, slx3, wu:fc26g01, zgc:66489, zgc:91801
alle Proteine anzeigen Gen GeneID UniProt
MUS81 71711 Q91ZJ0
MUS81 80198 Q96NY9
MUS81 293678 Q4KM32

Weitere Synonyme anzeigen

MUS81 Proteine (MUS81) nach Spezies

Wählen Sie die gewünschte Spezies

Weitere Proteine zu MUS81 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Interaktionspartner

  1. spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1.

  2. did not find any role for MUS81-MMS4 in meiotic crossing over

Arabidopsis thaliana MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Interaktionspartner

  1. SEND1 has at most a minor role in resolution of the Holliday junction but acts as an essential backup to MUS81 for resolution of toxic replication structures to ensure genome stability and to maintain telomere integrity.

  2. Data show that DNA polymerase zeta catalytic subunit REV3 cooperates with ATP-dependent DNA helicase RECQ4A and e ndonuclease MUS81 to repair DNA interstrand cross links.

  3. RECQ4A and MUS81 define RAD5A-independent pathways of DNA repair. RECQ4A and MUS81 act in parallel pathways presumably to resolve replication-associated DNA intermediates.

  4. The role of AtMUS81 in meiotic and mitotic recombination.

  5. AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.

  6. The role of MUS81 in the reproduction and growth of A. thaliana, via its expression and metabolism during meiosis, is reported.

  7. Both MUS81-EME1 (zeige EME1 Proteine) endonuclease complexes are involved in DNA recombination and repair processes in Arabidopsis.

Mouse (Murine) MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Interaktionspartner

  1. Our study highlights the importance of the cooperation between Rad54 (zeige RAD54L Proteine) and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.

  2. Mus81 knockdown improves the chemosensitivity of HCC (zeige FAM126A Proteine) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (zeige CHEK1 Proteine) pathway, suggesting Mus81 as a novel therapeutic target for HCC (zeige FAM126A Proteine).

  3. Using mice deficient in both Mus81 and the FA pathway protein FancC (zeige FANCC Proteine), we show both proteins cooperate in parallel pathways, as concomitant loss of FancC (zeige FANCC Proteine) and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.

  4. Data indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  5. FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.

  6. data indicate that an important role for Chk2 (zeige CHEK2 Proteine) is maintaining lymphocyte development and that dual inactivation of Chk2 (zeige CHEK2 Proteine) and Mus81 remarkably inhibits cancer

  7. studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression

  8. Mus81 acts at a late step in the repair of cross-link-induced lesions

  9. Mus81-Eme1 (zeige EME1 Proteine)- and Rad54 (zeige RAD54L Proteine)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway

  10. Data suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair.

Human MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Interaktionspartner

  1. The mitotic DNA synthesis is RAD52 (zeige RAD52 Proteine) dependent, and RAD52 (zeige RAD52 Proteine) is required for the timely recruitment of MUS81 and POLD3 (zeige POLD3 Proteine) to common fragile sites in early mitosis.

  2. Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81-EME1 (zeige EME1 Proteine) resolving enzyme complex. (GEN1 = Holliday junction 5' flap (zeige ALOX5AP Proteine) endonuclease; SLX = structure-specific endonuclease subunit; MUS81 = MUS81 endonuclease; EME1 (zeige EME1 Proteine) = essential meiotic endonuclease 1) [REVIEW]

  3. down-regulation of MUS81 expression in ovarian cancer cells inhibited cell proliferation and colony formation ability, and influenced cell cycle progression

  4. SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 (zeige EME1 Proteine) Protein by HIV-1 Viral Protein R (Vpr).

  5. Mus81 sumoylation is important for normal mitotic chromosome congression.

  6. Data suggest that the ATM (zeige ATM Proteine)/Chk2 (zeige CHEK2 Proteine) may promote the repair of DNA damage caused by cisplatin by sustaining methyl methanesulfonate and ultraviolet-sensitive gene clone 81, and the double-strand breaks generated by methyl methanesulfonate and ultraviolet-sensitive gene clone 81 may activate the ATM (zeige ATM Proteine)/Chk2 (zeige CHEK2 Proteine) pathway.

  7. Avoiding damage formation through invalidation of Mus81-Eme2 (zeige EME2 Proteine) and Mre11 (zeige MRE11A Proteine), or preventing damage signaling by turning off the ATM (zeige ATM Proteine) pathway, suppresses the replication phenotypes of Chk1 (zeige CHEK1 Proteine)-deficient cells.

  8. Mus81 knockdown improves the chemosensitivity of HCC (zeige FAM126A Proteine) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (zeige CHEK1 Proteine) pathway, suggesting Mus81 as a novel therapeutic target for HCC (zeige FAM126A Proteine).

  9. Mus81 regulates the rate of DNA replication during normal growth by promoting replication fork progression while reducing the frequency of replication initiation events.

  10. Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.MUS81 function in DNA interstrand crosslinks repair requires interaction with SLX4.

MUS81 Protein Überblick

Protein Überblick

Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Alternative names and synonyms associated with MUS81

  • CG3026 gene product from transcript CG3026-RA (mus81)
  • MUS81 endonuclease homolog (S. cerevisiae) (MUS81)
  • MUS81 structure-specific endonuclease subunit (mus81)
  • mus81 protein (mus81)
  • crossover junction endonuclease MUS81 (MUS81)
  • Mus81p (MUS81)
  • Holliday junction resolvase subunit Mus81 (mus81)
  • MUS81 protein (mus81)
  • MUS81 endonuclease homolog (yeast) (Mus81)
  • MUS81 endonuclease homolog (yeast) (mus81)
  • MUS81 structure-specific endonuclease subunit (MUS81)
  • MUS81 structure-specific endonuclease subunit (Mus81)
  • similar to S. cerevisiae MUS81p (YDR386W) which is part of an endonuclease involved in repair of damaged DNA replication forks (MUS81)
  • 1200008A18Rik Protein
  • AI182501 Protein
  • ARABIDOPSIS THALIANA MMS AND UV SENSITIVE 81 Protein
  • ATMUS81 Protein
  • AW045863 Protein
  • CG3026 Protein
  • Dmel\\CG3026 Protein
  • EG:BACR7A4.16 Protein
  • F6I18.220 Protein
  • F6I18_220 Protein
  • GB15332 Protein
  • MMS AND UV SENSITIVE 81 Protein
  • MUS81 Protein
  • slx3 Protein
  • wu:fc26g01 Protein
  • zgc:66489 Protein
  • zgc:91801 Protein

Bezeichner auf Proteinebene für MUS81

CG3026-PA , mus81-PA , crossover junction endonuclease MUS81 , MUS81 endonuclease homolog (S. cerevisiae) , MUS81 endonuclease homolog , MUS81 protein , crossover junction endonuclease MUS81-like , SLX3 structure-specific endonuclease subunit homolog , hypothetical protein

GENE ID SPEZIES
31044 Drosophila melanogaster
466667 Pan troglodytes
476021 Canis lupus familiaris
496413 Xenopus (Silurana) tropicalis
725951 Apis mellifera
829211 Arabidopsis thaliana
851994 Saccharomyces cerevisiae S288c
2539004 Schizosaccharomyces pombe 972h-
10804405 Sordaria macrospora k-hell
100029893 Monodelphis domestica
100051745 Equus caballus
100459560 Pongo abelii
100464481 Ailuropoda melanoleuca
100511000 Sus scrofa
100590455 Nomascus leucogenys
71711 Mus musculus
406839 Danio rerio
80198 Homo sapiens
293678 Rattus norvegicus
3647146 Candida albicans SC5314
Ausgewählte Anbieter für MUS81 Proteine (MUS81)
Haben Sie etwas anderes gesucht?