anti-Maus MSH6 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended MSH6 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
MutS Homolog 6 (E. Coli) (MSH6) Antikörper
  • cb326
  • wu:fb36c12
  • LOC100227810
  • GTBP
  • GTMBP
  • HNPCC5
  • HSAP
  • p160
  • AU044881
  • AW550279
  • Gtmbp
  • mutS homolog 6 (E. coli)
  • LOC100360342
  • msh6
  • Msh6
  • MSH6
  • LOC100227810
Reaktivität
Human, Maus, Ratte (Rattus)
151
50
39
9
7
2
1
1
1
1
1
Wirt
Kaninchen
77
62
12
Klonalität
Polyklonal
Konjugat
Dieser MSH6 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
106
50
46
42
38
13
12
12
9
6
5
4
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN704366
304,36 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2804317 IF (p) Alexa Fluor 594 Rabbit IgG AA 830-880 Anmelden zum Anzeigen Polyclonal
1 ABIN704369 IF (p) Cy3 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN704370 IF (p) Cy5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN704371 IF (p) Cy5.5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN704372 IF (p) Cy7 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN704373 IF (p) FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN907071 IF (p) Alexa Fluor 488 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN907072 IF (p) Alexa Fluor 350 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN907073 IF (p) Alexa Fluor 647 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN907074 IF (p) Alexa Fluor 555 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN5007055 IF (p) Alexa Fluor 680 Rabbit IgG AA 830-880 Anmelden zum Anzeigen Polyclonal
1 ABIN5007056 IF (p) Alexa Fluor 750 Rabbit IgG AA 830-880 Anmelden zum Anzeigen Polyclonal

General

Antigen MutS Homolog 6 (E. Coli) (MSH6) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(151), (50), (39), (9), (7), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(77), (62), (12)
Klonalität
Polyklonal
Konjugat Dieser MSH6 Antikörper ist unkonjugiert
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(106), (50), (46), (42), (38), (13), (12), (12), (9), (6), (5), (4), (4), (3), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-MSH6 Antikörper

Target Details MSH6 Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human MSH6
Isotyp IgG

Target Details MSH6

Produktdetails anti-MSH6 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Msh6 (MSH6 Antibody Abstract)
Hintergrund

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.

Subcellular location: Nucleus

Synonyms: GTBP, HSAP, p160, GTMBP, HNPCC5, DNA mismatch repair protein Msh6, hMSH6, G/T mismatch-binding protein, MutS-alpha 160 kDa subunit, MSH6

Gen-ID 2956
UniProt P52701
Forschungsgebiet Chromatin and Nuclear Signaling, DNA/RNA
Pathways DNA Reparatur, Chromatin Binding, Production of Molecular Mediator of Immune Response

Anwendungsinformationen

Produktdetails anti-MSH6 Antikörper Target Details MSH6 Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-MSH6 Antikörper Target Details MSH6 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-MSH6 Antikörper Target Details MSH6 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN704366) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-MS...