MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Proteine (MSH2)

Bezeichnung:
MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Proteine (MSH2)
Auf www.antikoerper-online.de finden Sie aktuell 8 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Proteine von 1 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Antikörper (5) und MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 17 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Produkte verfügbar.
Synonyme:
AI788990, ATMSH2, CG7895, COCA1, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, FCC1, HNPCC, HNPCC1, HOX, LCFS2, msh-2, msh2, MUTS homolog 2, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, Tin, tin/NK4, wu:fc06b02, wu:fc13e09, zgc:55333
alle Proteine anzeigen Gen GeneID UniProt
Maus MSH2 MSH2 17685 P43247
Ratte MSH2 MSH2 81709 P54275
Human MSH2 MSH2 4436 P43246

Weitere Synonyme anzeigen

Weitere Proteine zu MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Interaktionspartnern

Arabidopsis thaliana MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Interaktionspartner

  1. The expression of AtMutSgamma (MSH7 and MSH2) in Saccharomyces cerevisiae suggest that AtMutSgamma affects yeast genomic stability by recognizing specific mismatches.

  2. The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated.

  3. reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis

Mouse (Murine) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Interaktionspartner

  1. Study shows that MSH2-/- mice develop spontaneous thymic lymphomas.

  2. Data show that in mutS homolog 2 protein Msh2(+/-) mice, azathioprine (Aza) induced a high incidence of microsatellite instability (MSI (zeige EBP Proteine)) lymphomas in a dose-dependent manner.

  3. In Msh2-/- mice, red meat enhanced survival compared to control (p<0.01) and lowered total tumour burden compared to resistant starch (p<0.167).

  4. Angptl2 (zeige ANGPTL2 Proteine)-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression.

  5. Gut (zeige GUSB Proteine) microbes did not induce colorectal cancer in APC (zeige APC Proteine)(Min/+)MSH2(-/-) mice through an inflammatory response or the production of DNA mutagens but rather by providing carbohydrate-derived metabolites such as butyrate that fuel hyperproliferation of MSH2(-/-) colon epithelial cells.

  6. MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in p53 (zeige TP53 Proteine)-deficient tumorigenesis.

  7. Results suggest that MSH2 is rate limiting for expansion in fragile X (zeige FMR1 Proteine) premutation mouse model and that MSH2 levels may be a key factor that accounts for tissue-specific differences in expansion risk.

  8. Toxicity, induced by tert (zeige TERT Proteine)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (zeige MPG Proteine) (+/+), Nth1 (+/+)) and deficient (Mpg (zeige MPG Proteine) (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 knockdown, was examined.

  9. Medium-spiny striatal neurons-specific deletion of Msh2 was sufficient to eliminate the vast majority of striatal HTT (zeige HTT Proteine) CAG expansions in HTT (zeige HTT Proteine) CAG knock-in mice.

  10. Enhanced occupancy of Msh2 and Msh3 proteins is detected downstream of the FXN (zeige FXN Proteine) expanded GAA (zeige GAA Proteine) repeat, suggesting a model in which Msh2/3 dimers are recruited to this region to repair mismatches.

Zebrafish MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Interaktionspartner

  1. Identification and characterization of novel knockout mutants of the three major MMR (zeige MRC1 Proteine) genes, mlh1 (zeige MLH1 Proteine), msh2, and msh6 (zeige MSH6 Proteine), in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Interaktionspartner

  1. Genetic changes between MLH1 (zeige MLH1 Proteine) and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 (zeige DVL3 Proteine) genes (p = 0.034).

  2. Here we demonstrate that in silico saturation mutagenesis and biophysical calculations of the structural stability of the human mismatch repair protein MSH2 correlate with cellular protein levels, turnover and function. Of 24 different MSH2 variants, some of which are linked to Lynch syndrome, a destabilization of as little as 3 kcal/mol (zeige DUOXA1 Proteine) is sufficient to cause rapid degradation via the ubiquitin-proteasome pathway.

  3. human Pol alpha interacts with MSH2-MSH6 (zeige MSH6 Proteine) complex

  4. In colorectal neoplasms, negative expression of the MMR (zeige MRC1 Proteine) proteins MLH1 (zeige MLH1 Proteine), MSH2 or MSH6 (zeige MSH6 Proteine) was seen in 15% (47 of 313) of the patients. Defect MLH1 (zeige MLH1 Proteine) was most common and detected in 12% of the cases. Defect MLH1 (zeige MLH1 Proteine) and MSH2 were identified in each patient's normal adjacent mucosa.

  5. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (zeige FMR1 Proteine) gene

  6. The expression of genes and proteins related to DNA repair mechanism MLH1 (zeige MLH1 Proteine), MSH2 and ATM (zeige ATM Proteine) in the normal oral mucosa of chronic smokers was reduced.

  7. The expression of genes and proteins related to DNA repair mechanism MLH1 (zeige MLH1 Proteine), MSH2 and ATM (zeige ATM Proteine) in the normal oral mucosa of chronic smokers was reduced.

  8. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (zeige MLH1 Proteine) in 40%, MSH2 in 36%, MSH6 (zeige MSH6 Proteine) in 18% and PMS2 (zeige PMS2 Proteine) in 6% of the families.

  9. There is a positive correlation between the expressions of hMSH2 and hMSH6 (zeige MSH6 Proteine) between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  10. Individuals with Lynch syndrome and double-mutants in MSH6 (zeige MSH6 Proteine) and MSH2 had normal MSH2 expression, whereas MSH6 (zeige MSH6 Proteine) immunoexpression was lost in all evaluable cases.

Fruit Fly (Drosophila melanogaster) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Interaktionspartner

  1. Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur (zeige ABCC8 Proteine) expression. By adding MEF2 (zeige MYEF2 Proteine) alongside Tinman and Pannier, an expansion in expression of Hand and Sur (zeige ABCC8 Proteine) was observed.

  2. Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2 (zeige MYEF2 Proteine)-dependent muscle differentiation can proceed.

  3. Plasticity in Hox/PBC (zeige DLAT Proteine) interaction modes is a common molecular strategy for shaping Hox transcriptional activities.

  4. The enhancers active in the heart progenitor cells and the heart generally are dependent on tinman gene activity, whereas those active in non-cardiac mesoderm are often bound neutrally by Tinman

  5. Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.

  6. Tin is a direct regulator of midline in fly heart development.

  7. wg and dpp (zeige TGFb Proteine) contribute progressively to the elaboration of the expression pattern of the mesoderm-specific homeobox (zeige PRRX1 Proteine)-containing gene tinman (tin), and the overlap of wg and dpp (zeige TGFb Proteine) in the presence of tin-expressing cells directs cardiac-specific differentiation

  8. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm.

  9. one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp (zeige TGFb Proteine) in the dorsal mesoderm has ceased

  10. dSUR is regulated by tinman and plays a protective role against hypoxic stress and pacing-induced heart failure

MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Protein Überblick

Protein Überblick

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2)

  • mismatch repair protein (MSH2)
  • DNA mismatch repair protein Msh2 (MSH2)
  • mutS homolog 2 (E. coli) (Msh2)
  • mutS homolog 2 (E. coli) (msh2)
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2)
  • tinman (tin)
  • AI788990 Protein
  • ATMSH2 Protein
  • CG7895 Protein
  • COCA1 Protein
  • Dmel\CG7895 Protein
  • DmNK-4 Protein
  • DROHOXHK4 Protein
  • DROHOXNK4 Protein
  • FCC1 Protein
  • HNPCC Protein
  • HNPCC1 Protein
  • HOX Protein
  • LCFS2 Protein
  • msh-2 Protein
  • msh2 Protein
  • MUTS homolog 2 Protein
  • NK-4 Protein
  • NK-4/msh-2 Protein
  • NK4 Protein
  • NK4/msh-2 Protein
  • NKX2.5 Protein
  • Tin Protein
  • tin/NK4 Protein
  • wu:fc06b02 Protein
  • wu:fc13e09 Protein
  • zgc:55333 Protein

Bezeichner auf Proteinebene für MSH2

mismatch repair protein , DNA mismatch repair protein Msh2 , mutS protein homolog 2 , mismatch repair protein Msh2 , hMSH2 , mutS-like protein 2 , MutS-like protein 2 , CG7895-PA , muscle-specific-homeodomain-2 , tin-PA

GENE ID SPEZIES
100268052 Vitis vinifera
821383 Arabidopsis thaliana
17685 Mus musculus
81709 Rattus norvegicus
406845 Danio rerio
4436 Homo sapiens
378799 Gallus gallus
494002 Canis lupus familiaris
100337661 Sus scrofa
533115 Bos taurus
42536 Drosophila melanogaster
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