MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteine (MRE11A)

Bezeichnung:
MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteine (MRE11A)
Auf www.antikoerper-online.de finden Sie aktuell 7 MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Antikörper (193) und MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 215 MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Produkte verfügbar.
Synonyme:
ATLD, HNGS1, MRE11, MRE11B, wu:faa63d12, zgc:64018
alle Proteine anzeigen Gen GeneID UniProt
MRE11A 17535 Q61216
MRE11A 4361 P49959
MRE11A 64046 Q9JIM0

Weitere Synonyme anzeigen

MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteine (MRE11A) nach Spezies

Wählen Sie die gewünschte Spezies

Am meisten referenzierte MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteine

  1. Human MRE11A Protein expressed in Wheat germ - ABIN1311266 : Lee, Padget, Curtis, Cowell, Moiani, Sondka, Morris, Jackson, Cockell, Tainer, Austin: MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. in Biology open 2012 (PubMed)

Weitere Proteine zu MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Interaktionspartnern

Mouse (Murine) MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) Interaktionspartner

  1. cyclin A2 (zeige CCNA2 Proteine) controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.

  2. MRE11 complex influences the elimination of oocytes with unrepaired meiotic double-strand breaks post-natally, in addition to its previously described role in double-strand break repair and homologous synapsis during female meiosis.

  3. Inhibiting MRE11 by mirin during meiotic maturation results in anaphase bridges and also increases the number of gammaH2AX (zeige H2AFX Proteine) foci in metaphase II. Compromised DNA integrity in mirin-treated oocytes indicates a role for MRE11 in chromosome integrity during meiotic maturation.

  4. The authors demonstrate that ATM (zeige ATM Proteine) can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50 (zeige RAD50 Proteine)-NBS1 (zeige NBN Proteine) (MRN) sensor complex.

  5. TRIP13 (zeige TRIP13 Proteine)-deficient spermatocytes also progress to an H1t (zeige HIST1H1T Proteine)-positive stage if ATM (zeige ATM Proteine) activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 (zeige NBN Proteine) or by elimination of the ATM (zeige ATM Proteine)-effector kinase CHK2 (zeige CHEK2 Proteine)

  6. Impairment of Mre11 complex functions promotes the progression of mammary hyperplasias into invasive and metastatic breast cancers

  7. results suggest that the MRE11-RAD50 (zeige RAD50 Proteine) complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses

  8. The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR/CHK1 (zeige CHEK1 Proteine) checkpoint signaling.

  9. Mre11 is present in mitochondria where it binds to mtDNA and that the amount in mitochondria varies depending on cellular stress and differentiation.

  10. Data show that CS-mediated SCC (zeige CYP11A1 Proteine) lethality was mitigated in irradiated gain-of-function Rad50 (zeige RAD50 Proteine)(s/s) mice, and epistasis studies order Rad50 (zeige RAD50 Proteine) upstream of Mre11.

Human MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) Interaktionspartner

  1. Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2 (zeige TDP2 Proteine), an enzyme that eliminates covalent Top2 (zeige TOP2A Proteine) conjugates; thus, the essential role of Mre11 nuclease (zeige DCLRE1C Proteine) activity is likely to remove the DNA lesions.

  2. The results illuminate the important role of Nbs1 (zeige NBN Proteine) and CtIP (zeige RBBP8 Proteine) in determining the substrates and consequences of human Mre11/Rad50 (zeige RAD50 Proteine) nuclease (zeige DCLRE1C Proteine) activities on protein-DNA lesions.

  3. Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1.

  4. Ataxia (zeige USP14 Proteine)-telangiectasia-like disease (A-TLD (zeige BMP1 Proteine)) is clinically similar to mild Ataxia (zeige USP14 Proteine)-telangiectasia and caused by hypomorphic mutations in the MRE11 gene.

  5. although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  6. The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer.

  7. The high expression of MRE11-RAD50 (zeige RAD50 Proteine)-NBS1 (zeige NBN Proteine) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

  8. The expression of DSB repair proteins such as RAD51 (zeige RAD51 Proteine) and MRE11 was investigated by immunohistochemistry, and associations between RAD51 (zeige RAD51 Proteine) and MRE11 expression and clinicopathological factors or chemotherapeutic effect were assessed

  9. The MRN complex is essential to restrain MYCN (zeige MYCN Proteine)-induced replication stress during neural cell proliferation.

  10. This study found a significant trend indicating that the risk increases as the number of adverse alleles increase and significant three-locus interaction model involving NBS1 (zeige NBN Proteine) rs1805794, MRE11 rs10831234, and ATM (zeige ATM Proteine) rs227062.

MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A) Protein Überblick

Protein Überblick

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Alternative names and synonyms associated with MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A)

  • meiotic recombination 11 homolog A (S. cerevisiae) (mre11a)
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (MRE11A)
  • meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a)
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (Mre11a)
  • ATLD Protein
  • HNGS1 Protein
  • MRE11 Protein
  • MRE11B Protein
  • wu:faa63d12 Protein
  • zgc:64018 Protein

Bezeichner auf Proteinebene für MRE11A

meiotic recombination 11 homolog A , MRE11 meiotic recombination 11 homolog A (S. cerevisiae) , MRE11 homolog 1 , MRE11 homolog A , double-strand break repair protein MRE11A , meiotic recombination 11 homolog 1 , mmMRE11A , AT-like disease , DNA recombination and repair protein , endo/exonuclease Mre11 , meiotic recombination 11-like protein

GENE ID SPEZIES
406637 Danio rerio
737902 Pan troglodytes
100356946 Oryctolagus cuniculus
17535 Mus musculus
4361 Homo sapiens
64046 Rattus norvegicus
494006 Canis lupus familiaris
Ausgewählte Anbieter für MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) Proteine (MRE11A)
Haben Sie etwas anderes gesucht?