anti-MLH1 (MLH1) Antikörper

Bezeichnung:
anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Antikörper (MLH1)
Auf www.antikoerper-online.de finden Sie aktuell 179 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MLH1 Proteine (9) und MLH1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 199 MLH1 Produkte verfügbar.
Synonyme:
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301

Meistgesuchte Reaktivitäten zu anti-MLH1 (MLH1) Antikörper

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anti-Mouse (Murine) MLH1 Antikörper:

anti-Human MLH1 Antikörper:

anti-Rat (Rattus) MLH1 Antikörper:

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Am meisten referenzierte anti-MLH1 Antikörper

  1. Human Monoclonal MLH1 Primary Antibody für IHC (fro), IHC (p) - ABIN967314 : Baker, Plug, Prolla, Bronner, Harris, Yao, Christie, Monell, Arnheim, Bradley, Ashley, Liskay: Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. in Nature genetics 1996 (PubMed)
    Zeige alle 7 Referenzen für 967314

  2. Human Monoclonal MLH1 Primary Antibody für IP, WB - ABIN967392 : Prolla, Christie, Liskay: Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. in Molecular and cellular biology 1994 (PubMed)
    Zeige alle 3 Referenzen für 967392

  3. Human Monoclonal MLH1 Primary Antibody für ICC, IHC - ABIN969285 : Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). in Familial cancer 2008 (PubMed)
    Zeige alle 3 Referenzen für 969285

  4. Human Polyclonal MLH1 Primary Antibody für ELISA, WB - ABIN1534468 : Bronner, Baker, Morrison, Warren, Smith, Lescoe, Kane, Earabino, Lipford, Lindblom: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. in Nature 1994 (PubMed)
    Zeige alle 2 Referenzen für 1534468

  5. Hamster Monoclonal MLH1 Primary Antibody für IHC (p) - ABIN115274 : Pearson, Pinkerton, Lewis, Imeson, Ellershaw, Machin, ,: High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. in The lancet oncology 2008 (PubMed)

  6. Human Polyclonal MLH1 Primary Antibody für IHC (p), IP - ABIN151469 : Shen, Hu, Jeng, Chang, Lin, Chang, Hsu, Cheng: Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)

  7. Cow (Bovine) Polyclonal MLH1 Primary Antibody für WB - ABIN2786501 : Harley, Rosen, Risch, Siminovitch, Beiner, McLaughlin, Sun, Narod: Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1. in Gynecologic oncology 2008 (PubMed)

Weitere Antikörper gegen MLH1 Interaktionspartner

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Results suggest that Xenopus MBD4 (zeige MBD4 Antikörper)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (zeige MRC1 Antikörper) genes, mlh1, msh2 (zeige MSH2 Antikörper), and msh6 (zeige MSH6 Antikörper), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  2. high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected

  3. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  4. these data identify Mlh1 and Mlh3 (zeige MLH3 Antikörper) as novel critical genetic modifiers of HTT (zeige HTT Antikörper) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  5. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  6. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  7. suggesting a role for the ATPase (zeige DNAH8 Antikörper) activity of MLH1 beyond the activation of the endonuclease functions of its MMR (zeige MRC1 Antikörper) partner PMS2 (zeige PMS2 Antikörper)

  8. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (zeige ARHGEF16 Antikörper) and brain tumour multicellular spheroids.

  9. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  10. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (zeige MRC1 Antikörper) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. MLH1 mutations contribute to colorectal cancer susceptibility in Algerian families with suspected Lynch syndrome.

  2. MLH1 methylation analysis defines a subset of tumors that have worse prognostic features including higher tumor volume and lymph node involvement.

  3. High MLH1 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA (zeige PLAG1 PLURAL_@3975@) recurrence in prostate cancer.

  4. MLH1 methylation is a frequent molecular event in colorectal cancer and lung cancer patients

  5. Both the mTOR (zeige FRAP1 Antikörper)/p-mTOR (zeige FRAP1 Antikörper) and BNIP3 (zeige BNIP3 Antikörper)/Beclin-1 (zeige BECN1 Antikörper) signaling pathways were found to be related to HRS, but only mTOR (zeige FRAP1 Antikörper)/p-mTOR (zeige FRAP1 Antikörper) is involved in the regulation of HRS via MLH1 and autophagy.

  6. Data suggest that yeast Mlh1-Mlh3 (zeige MLH3 Antikörper) heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1-Mlh3 (zeige MLH3 Antikörper) heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1-PMS2 (zeige PMS2 Antikörper) exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 (zeige PMS2 Antikörper) = post meiotic segregation increased 2 protein)

  7. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  8. Genetic changes between MLH1 and MSH2 (zeige MSH2 Antikörper) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (zeige MSH2 Antikörper) and DVL3 (zeige DVL3 Antikörper) genes (p = 0.034).

  9. Mismatch repair (MMR (zeige MRC1 Antikörper))-deficient endometrial carcinomas have significantly increased tumoral and immune stromal PD-L1 (zeige CD274 Antikörper) expression relative to MMR (zeige MRC1 Antikörper)-intact carcinomas. PD-L1 (zeige CD274 Antikörper) is frequently positive in both tumoral and immune cells at the periphery of MMR (zeige MRC1 Antikörper)-deficient tumors. Lynch syndrome-associated tumors are more likely to express PDL1 (zeige CD274 Antikörper) relative to sporadic MLH1 promoter hypermethylation carcinomas.

  10. These results demonstrate the role of variant rs1800734 in altering transcription factor binding as well as epigenetics at regions beyond the MLH1 CpG island in which it is located.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Antigen-Profil

Beschreibung des Gens

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1) Antikörper
  • CG11482 gene product from transcript CG11482-RB (Mlh1) Antikörper
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1) Antikörper
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1) Antikörper
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198) Antikörper
  • mutL homolog 1 (E. coli) (Mlh1) Antikörper
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1) Antikörper
  • 1110035C23Rik Antikörper
  • AI317206 Antikörper
  • AI325952 Antikörper
  • AI561766 Antikörper
  • CG11482 Antikörper
  • COCA2 Antikörper
  • Dmel\\CG11482 Antikörper
  • dmlh-1 Antikörper
  • dmlh1 Antikörper
  • FCC2 Antikörper
  • hMLH1 Antikörper
  • HNPCC Antikörper
  • HNPCC2 Antikörper
  • LOC100232198 Antikörper
  • MLH1 Antikörper
  • zgc:66301 Antikörper

Bezeichner auf Proteinebene für MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID SPEZIES
420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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