Ligase II, DNA, ATP-Dependent (LIG2) ELISA Kits

Ligase II, DNA, ATP-Dependent ELISA Kits (LIG2)
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list all ELISA KIts Gen GeneID UniProt
Human LIG2 LIG2 3980 P49916

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Human Ligase II, DNA, ATP-Dependent (LIG2) Interaktionspartner

  1. The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases.

  2. A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 (zeige XRCC1 ELISA Kits) gene on binding interaction of XRCC1 (zeige XRCC1 ELISA Kits) protein with ligase III.

  3. In the context of tyrosine kinase (zeige TXK ELISA Kits)-activated leukemias, c-MYC (zeige MYC ELISA Kits) contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 (zeige PARP1 ELISA Kits) up-regulation.

  4. there is an absolute requirement for fully functional DNA ligase III (LIG3 (zeige LIG3 ELISA Kits)), but not ligase IV (LIG4 (zeige LIG4 ELISA Kits)), to facilitate the escape from a telomere-driven crisis.

  5. Results show that overexpression of DNA ligase III (zeige LIG3 ELISA Kits) in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress.

  6. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM (zeige ATM ELISA Kits) in regulating DNA Lig3 stability and consequently mtDNA repair

  7. Human Mre11 (zeige MRE11A ELISA Kits)/human Rad50 (zeige RAD50 ELISA Kits)/Nbs1 (zeige NBN ELISA Kits) and DNA ligase IIIalpha/XRCC1 (zeige XRCC1 ELISA Kits) protein complexes act together in an alternative nonhomologous end joining pathway.

  8. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.

  9. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 (zeige XRCC1 ELISA Kits)

  10. The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site.

Ligase II, DNA, ATP-Dependent (LIG2) Antigen-Profil

Beschreibung des Gens

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Ligase II, DNA, ATP-Dependent (LIG2)

  • ligase III, DNA, ATP-dependent (LIG3) Elisa Kit
  • LIG2 Elisa Kit

Bezeichner auf Proteinebene für LIG2

DNA ligase 3 , ligase II, DNA, ATP-dependent , polydeoxyribonucleotide synthase [ATP] 3

3980 Homo sapiens
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