LIG1 Proteine (LIG1)

Bezeichnung:
Ligase I, DNA, ATP-Dependent Proteine (LIG1)
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Synonyme:
AL033288, ATLIG1, DNA ligase 1, lig1, LigI, T6D22.23, wu:fc54a11
alle Proteine anzeigen Gen GeneID UniProt
LIG1 3978 P18858
LIG1 16881 P37913
LIG1 81513  

Weitere Synonyme anzeigen

LIG1 Proteine (LIG1) nach Spezies

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Am meisten referenzierte LIG1 Proteine

  1. Human LIG1 Protein expressed in HEK-293 Cells - ABIN2719545 : Liu, Lu, Ali, Liu, Zheng, Dai, Li, Xu, Hua, Zhou, Ortega, Li, Kunkel, Shen: Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex. in The EMBO journal 2015 (PubMed)

Weitere Proteine zu LIG1 Interaktionspartnern

Arabidopsis thaliana Ligase I, DNA, ATP-Dependent (LIG1) Interaktionspartner

  1. The AtLIG1 is an important component of the active DNA demethylation machinery.

  2. LIG1 is required for both single-nucleotide or long-patch base excision repair.

  3. In the study, we show that loss-of-function of the major DNA LIGASE I (AtLIG1) in Arabidopsis thaliana causes maternal effects in the endosperm, which is the seed tissue that nurtures embryo development.

  4. Nuclear or mitochondrial targeting of LIG1 is accomplished through an evolutionarily conserved translation initiation mechanism. [AtLIG1]

  5. DNA ligase 1 functions in both DNA replication and in repair of both ss and dsDNA strand breaks.

Human Ligase I, DNA, ATP-Dependent (LIG1) Interaktionspartner

  1. The rs156641 polymorphism of DNA ligase 1 (LIG1) was significantly associated with lung cancer risk, whereas no association was found between rs3730931/rs439132/rs20579 polymorphisms and lung cancer.

  2. Data suggest that DNA ligase I (LigI)-deficient 46BR.1G1 cells represent a model to investigate the biological effects of sub-lethal levels of DNA insults.

  3. The LIG1 CC genotype was associated with susceptibility to non-small cell lung cancer, and the AA genotype demonstrated increased radiosensitivity compared to the AC and CC genotypes.

  4. Ppolymorphisms in LIG1 affect its expression and may therefore change its function.

  5. there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women

  6. DNA ligase I also interacts with replication factor C, the factor that loads the PCNA (zeige PCNA Proteine) trimeric ring onto DNA.

  7. Data indicate that Ku70 (zeige XRCC6 Proteine)/Ku80 (zeige XRCC5 Proteine) facilitates the cooperative binding of multiple XRCC4 (zeige XRCC4 Proteine)/Ligase IV (XL) and XLF (zeige NHEJ1 Proteine) molecules to DNA.

  8. Single nucleotide polymorphisms in LIG1 are associated with myelodysplastic syndromes.

  9. phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC (zeige RFC1 Proteine), which is required for efficient DNA replication and repair.

  10. Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53 (zeige TP53 Proteine), LIG1, and BIK (zeige BIK Proteine).

Mouse (Murine) Ligase I, DNA, ATP-Dependent (LIG1) Interaktionspartner

  1. Increased presynaptic glutamate (zeige GRIN1 Proteine) release is a key early event resulting from Lgi1 (zeige LGI1 Proteine)-deficiency, which likely contributes to epileptogenesis.

  2. Lig1 (zeige Lrig1 Proteine) is not absolutely required for cellular DNA replication and repair in Lig1 (zeige Lrig1 Proteine)-null cell line.

  3. LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.

  4. DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.

LIG1 Protein Überblick

Protein Überblick

LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Alternative names and synonyms associated with LIG1

  • ligase I, DNA, ATP-dependent (LIG1)
  • DNA ligase 1 (PB000674.02.0)
  • DNA ligase 1 (PTRG_06243)
  • DNA ligase 1 (PKH_140260)
  • DNA ligase 1 (LIG1)
  • ligase I, DNA, ATP-dependent (lig1)
  • ligase I, DNA, ATP-dependent (Lig1)
  • Protein LIG-1 (lig-1)
  • si:dkeyp-35b8.5 (si:dkeyp-35b8.5)
  • AL033288 Protein
  • ATLIG1 Protein
  • DNA ligase 1 Protein
  • lig1 Protein
  • LigI Protein
  • T6D22.23 Protein
  • wu:fc54a11 Protein

Bezeichner auf Proteinebene für LIG1

DNA ligase 1 , polydeoxyribonucleotide synthase [ATP] 1 , DNA ligase (ATP) 1 , DNA ligase I , LIG1, ligase I, DNA, ATP-dependent

GENE ID SPEZIES
100053186 Equus caballus
3425646 Plasmodium berghei ANKA
6344500 Pyrenophora tritici-repentis Pt-1C-BFP
7323359 Plasmodium knowlesi strain H
837333 Arabidopsis thaliana
3978 Homo sapiens
100124507 Bos taurus
397978 Xenopus laevis
100686967 Canis lupus familiaris
16881 Mus musculus
81513 Rattus norvegicus
100520434 Sus scrofa
179502 Caenorhabditis elegans
556995 Danio rerio
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