anti-Family with Sequence Similarity 175, Member A (FAM175A) Antikörper

Bezeichnung:
anti-Family with Sequence Similarity 175, Member A Antikörper (FAM175A)
Auf www.antikoerper-online.de finden Sie aktuell 53 Family with Sequence Similarity 175, Member A (FAM175A) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Family with Sequence Similarity 175, Member A Proteine (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 69 Family with Sequence Similarity 175, Member A Produkte verfügbar.
Synonyme:
3830405G04Rik, 5630400M01Rik, ABRA1, AI506069, AL024423, AV118690, Ccdc98, fam175a, RGD1305287, zgc:103522

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Am meisten referenzierte anti-Family with Sequence Similarity 175, Member A Antikörper

  1. Human Polyclonal FAM175A Primary Antibody für IHC, ELISA - ABIN1002067 : Kim, Huang, Chen: CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. in Nature structural & molecular biology 2007 (PubMed)
    Zeige alle 3 Referenzen für 1002067

  2. Human Monoclonal FAM175A Primary Antibody für FACS, IP - ABIN1302443 : Wang, Elledge: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Zeige alle 3 Referenzen für 1302443

Weitere Antikörper gegen Family with Sequence Similarity 175, Member A Interaktionspartner

Human Family with Sequence Similarity 175, Member A (FAM175A) Interaktionspartner

  1. Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied.

  2. Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR.

  3. Abraxas and RAP80 (zeige UIMC1 Antikörper) were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair.

  4. CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.

  5. CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.

  6. the human Ubc13 (zeige UBE2N Antikörper)/Rnf8 (zeige RNF8 Antikörper) ubiquitin ligases control foci formation of the Rap80 (zeige UIMC1 Antikörper)/Abraxas/Brca1/Brcc36 (zeige BRCC3 Antikörper) complex in response to DNA damage

  7. Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2 (zeige BRCA2 Antikörper), suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene.

  8. it seems unlikely that moderate to highly penetrant alleles of either RAP80 (zeige UIMC1 Antikörper) or Abraxas, confer a significantly high relative risk of breast cancer.

  9. examined RAP80 (zeige UIMC1 Antikörper) and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer

Family with Sequence Similarity 175, Member A (FAM175A) Antigen-Profil

Beschreibung des Gens

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of brca1 (By similarity).

Alternative names and synonyms associated with Family with Sequence Similarity 175, Member A (FAM175A)

  • coiled-coil domain containing 98 (CCDC98) Antikörper
  • Coiled-coil domain-containing protein 98 (ccd98) Antikörper
  • family with sequence similarity 175, member A (FAM175A) Antikörper
  • family with sequence similarity 175, member A (Fam175a) Antikörper
  • family with sequence similarity 175, member A (fam175a) Antikörper
  • 3830405G04Rik Antikörper
  • 5630400M01Rik Antikörper
  • ABRA1 Antikörper
  • AI506069 Antikörper
  • AL024423 Antikörper
  • AV118690 Antikörper
  • Ccdc98 Antikörper
  • fam175a Antikörper
  • RGD1305287 Antikörper
  • zgc:103522 Antikörper

Bezeichner auf Proteinebene für FAM175A

coiled-coil domain containing 98 , BRCA1-A complex subunit Abraxas , Protein FAM175A , abraxas protein , coiled-coil domain-containing protein 98

GENE ID SPEZIES
461205 Pan troglodytes
100194936 Salmo salar
84142 Homo sapiens
70681 Mus musculus
289468 Rattus norvegicus
504796 Bos taurus
422608 Gallus gallus
478459 Canis lupus familiaris
449820 Danio rerio
443765 Xenopus laevis
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