anti-Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) Antikörper

Bezeichnung:
anti-Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) Antikörper (EME1)
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Synonyme:
6820428D13, EME1, fc30c07, MMS4L, SLX2A, wu:fc30c07
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus EME1 EME1 268465 Q8BJW7
Anti-Human EME1 EME1 146956 Q96AY2
Anti-Ratte EME1 EME1 287634  

Weitere Synonyme anzeigen

Weitere Antikörper gegen Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) Interaktionspartner

Mouse (Murine) Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) Interaktionspartner

  1. Study found that a Gen1 (zeige GEN1 Antikörper) mutation alone did not affect DNA repair or meiotic recombination in mice; it caused synthetic lethality when combined with Eme1 mutations at an early embryonic stage. Also, combination of Gen1 (zeige GEN1 Antikörper) and Eme1 mutations makes embryonic fibroblasts more sensitive to DNA damage & mice less capable of meiotic recombination. These results indicate that Gen1 (zeige GEN1 Antikörper) and Eme1 are functionally redundant in mice.

  2. indicate that SLX1 and MUS81 (zeige MUS81 Antikörper)-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4 (zeige BTBD12 Antikörper).

  3. Mus81 (zeige MUS81 Antikörper)-Eme1- and Rad54 (zeige RAD54L Antikörper)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway

  4. These findings link Eme1 with the replication-associated chromatin modifier functions of Np95 (zeige UHRF1 Antikörper) in the cellular response to DNA damage.

Human Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) Interaktionspartner

  1. SLX4 (zeige BTBD12 Antikörper)-SLX1 Protein-independent Down-regulation of MUS81 (zeige MUS81 Antikörper)-EME1 Protein by HIV-1 Viral Protein R (Vpr).

  2. While Mus81 (zeige MUS81 Antikörper)-Eme1 shares several common features with members of the 5' flap (zeige ALOX5AP Antikörper) nuclease (zeige DCLRE1C Antikörper) family, the combined structural, biochemical, and biophysical analyses explain why Mus81 (zeige MUS81 Antikörper)-Eme1 preferentially cleaves 3' flap (zeige ALOX5AP Antikörper) DNA substrates with 5' nicked ends.

  3. Data show that three structure-selective endonucleases, SLX1-SLX4 (zeige BTBD12 Antikörper), MUS81 (zeige MUS81 Antikörper)-EME1, and GEN1 (zeige GEN1 Antikörper), define two pathways of Holliday junctions (HJs) resolution in HeLa cells.

  4. Data show that Mus81 (zeige MUS81 Antikörper)/Eme1-dependent DNA damage--rather than a global increase in replication-fork stalling--is the cause of incomplete replication in Chk1 (zeige CHEK1 Antikörper)-deficient cells.

  5. Results demonstrate a novel role of Wee1 (zeige WEE1 Antikörper) in controlling Mus81 (zeige MUS81 Antikörper)-Eme1 and DNA replication in human cells.

  6. EME-1 deficiency affects cell cycle progression and promotes DNA rereplication.

  7. Mus81 (zeige MUS81 Antikörper)-Eme1 can ensure coordinate, bilateral cleavage of Holliday junction-like structures.

  8. the crystal structure of the Mus81 (zeige MUS81 Antikörper)-Eme1 complex

  9. results demonstrate a link between branch migration activity of hRad54 (zeige RAD54L Antikörper) and structure-specific endonuclease activity of hMus81-Eme1, suggesting that the Rad54 (zeige ATRX Antikörper) and Mus81 (zeige MUS81 Antikörper)-Eme1 proteins may cooperate in the processing of Holliday junction-like intermediates

  10. Low Eme1 levels were more sensitive to the drug than tumors with high levels.

Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Essential Meiotic Endonuclease 1 Homolog 1 (S. Pombe) (EME1)

  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (EME1) Antikörper
  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (eme1) Antikörper
  • essential meiotic structure-specific endonuclease subunit 2 (eme2) Antikörper
  • essential meiotic endonuclease 1 homolog 1 (S. pombe) (Eme1) Antikörper
  • essential meiotic structure-specific endonuclease 1 (EME1) Antikörper
  • essential meiotic structure-specific endonuclease 1 (Eme1) Antikörper
  • essential meiotic structure-specific endonuclease 1 (eme1) Antikörper
  • 6820428D13 Antikörper
  • EME1 Antikörper
  • fc30c07 Antikörper
  • MMS4L Antikörper
  • SLX2A Antikörper
  • wu:fc30c07 Antikörper

Bezeichner auf Proteinebene für EME1

essential meiotic endonuclease 1 homolog 1 (S. pombe) , essential meiotic endonuclease 1 homolog 2 , probable crossover junction endonuclease EME2 , crossover junction endonuclease EME1 , MMS4 homolog , SLX2 structure-specific endonuclease subunit homolog A , essential meiotic endonuclease 1 homolog 1 , hMMS4 , homolog of yeast EME1 endonuclease

GENE ID SPEZIES
422104 Gallus gallus
558350 Danio rerio
702273 Macaca mulatta
747125 Pan troglodytes
780321 Xenopus (Silurana) tropicalis
100056366 Equus caballus
491079 Canis lupus familiaris
100125299 Bos taurus
268465 Mus musculus
146956 Homo sapiens
287634 Rattus norvegicus
100137639 Xenopus laevis
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