DDB2 Proteine (DDB2)

Bezeichnung:
Damage-Specific DNA Binding Protein 2, 48kDa Proteine (DDB2)
Auf www.antikoerper-online.de finden Sie aktuell 9 Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DDB2 Antikörper (42) und DDB2 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 59 DDB2 Produkte verfügbar.
Synonyme:
2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2
alle Proteine anzeigen Gen GeneID UniProt
DDB2 107986 Q99J79
Ratte DDB2 DDB2 100362121  
DDB2 1643 Q92466

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Am meisten referenzierte DDB2 Proteine

  1. Human DDB2 Protein expressed in Wheat germ - ABIN1351259 : Robu, Shah, Petitclerc, BrindAmour, Kandan-Kulangara, Shah: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

Weitere Proteine zu DDB2 Interaktionspartnern

Mouse (Murine) Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) Interaktionspartner

  1. UVRAG (zeige UVRAG Proteine) is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.

  2. Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer.

  3. Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1 (zeige PARP1 Proteine))collaborates with DNA-binding protein (zeige HSF4 Proteine) 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (zeige NR1H2 Proteine) (GG-NER (zeige NR1H2 Proteine)).

  4. the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies.

  5. These results demonstrate direct activation of the human DDB2 gene by p53 (zeige TP53 Proteine). The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 (zeige TP53 Proteine) binding and transcriptional activation.

  6. results demonstrate that DDB2 is well conserved between humans and mice and functions as a tumor suppressor, at least in part, by controlling p53 (zeige TP53 Proteine)-mediated apoptosis after UV-irradiation

  7. DDB2-deficient mice developed spontaneous malignant tumors at a high rate between the ages of 20 and 25 months.

  8. DDB2 is involved in global repair in mouse epithelial cells.

  9. Ddb2 heterozygosity can facilitate tumor development as a haploinsufficient tumor suppressor

  10. results indicate the bulk of DDB2 interacts with lesions independent of XPC (zeige XPC Proteine) & there is little interaction between the two recognition proteins on damaged DNA; propose a scenario in which DDB2 prepares UV-damaged chromatin for assembly of the NER (zeige NR1H2 Proteine) complex

Human Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) Interaktionspartner

  1. UVRAG (zeige UVRAG Proteine) is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.

  2. High DDB2 expression is associated with increased radioresistance of non-small cell lung cancer.

  3. data revealed that DDB2 is involved in early events occurring during metastatic progression of breast cancer cells and will contribute to define this protein as a new marker of metastatic progression in this type of cancer.

  4. DDB2 polymorphisms are associated with gastric cancer and atrophic gastritis risks.

  5. the release of NER (zeige NR1H2 Proteine) components such as DNA damage binding protein 2 (DDB2) and Xeroderma Pigmentosum complementation group C (zeige XPC Proteine) protein (zeige HNRNPC Proteine) (XPC (zeige XPC Proteine)) following oxidative stress might putatively involve their apoptotic role rather than DNA repair function.

  6. PKM2 interacts with DDB2 and reduces cell survival upon UV irradiation.

  7. DDB2 can bind to the promoter region of NEDD4L (zeige NEDD4L Proteine) and recruit enhancer of zeste homolog 2 (zeige EZH2 Proteine) histone methyltransferase to repress NEDD4L (zeige NEDD4L Proteine) transcription by enhancing histone H3 (zeige HIST3H3 Proteine) lysine 27 trimethylation at the NEDD4L (zeige NEDD4L Proteine) promoter.

  8. data demonstrated that the DDB2 IRES activity was promoted during stress conditions. These results reveal a novel mechanism contributing to DDB2 expression

  9. DDB2 is involved in ubiquitination and degradation of PAQR3 (zeige PAQR3 Proteine) in gastric cancer cells.

  10. DDB2 rs747650 is involved in androgen metabolism, inflammation processes and scar formation in severe acne.

DDB2 Protein Überblick

Protein Überblick

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.

Alternative names and synonyms associated with DDB2

  • damage-specific DNA binding protein 2, 48kDa (DDB2)
  • damage-specific DNA binding protein 2, 48kDa (ddb2)
  • damage specific DNA binding protein 2 (Ddb2)
  • damage-specific DNA binding protein 2 (ddb2)
  • 2610043A19Rik Protein
  • DDBB Protein
  • si:dkey-45f10.3 Protein
  • UV-DDB2 Protein

Bezeichner auf Proteinebene für DDB2

damage-specific DNA binding protein 2 (48kD) , damage-specific DNA binding protein 2, 48kDa , DNA damage-binding protein 2 , Damage-specific DNA-binding protein 2 , DNA damage-binding protein 2-like , damage-specific DNA-binding protein 2 , DDB p48 subunit , UV-DDB 2 , UV-damaged DNA-binding protein 2 , xeroderma pigmentosum group E protein

GENE ID SPEZIES
100051180 Equus caballus
451165 Pan troglodytes
483626 Canis lupus familiaris
493565 Xenopus (Silurana) tropicalis
713813 Macaca mulatta
100352386 Oryctolagus cuniculus
100390419 Callithrix jacchus
100454099 Pongo abelii
100605065 Nomascus leucogenys
107986 Mus musculus
100362121 Rattus norvegicus
100004133 Danio rerio
1643 Homo sapiens
519357 Bos taurus
423185 Gallus gallus
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