DDB1 Proteine (DDB1)

Bezeichnung:
Damage-Specific DNA Binding Protein 1, 127kDa Proteine (DDB1)
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Synonyme:
127kDa, AA408517, ddb1, DDBA, p127-Ddb1, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
alle Proteine anzeigen Gen GeneID UniProt
Maus DDB1 DDB1 13194 Q3U1J4
Human DDB1 DDB1 1642 Q16531
Ratte DDB1 DDB1 64470  

Weitere Synonyme anzeigen

Weitere Proteine zu DDB1 Interaktionspartnern

Mouse (Murine) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) Interaktionspartner

  1. SIRT7 (zeige SIRT7 Proteine) inhibits TR4 (zeige NR2C2 Proteine) degradation by deacetylation of DDB1.

  2. These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  3. uncovered a novel biological role for CUL4A (zeige CUL4A Proteine)-DDB1-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1 (zeige CRY1 Proteine)

  4. UCH-L1 disrupts a complex between the DDB1-CUL4 ubiquitin ligase complex.

  5. In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase (zeige RNF123 Proteine) complexes catalyzing the obstruction of the STAT2 (zeige STAT2 Proteine)-dependent antiviral state of cells to permit viral replication.

  6. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.

  7. These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells.

  8. DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability.

Human Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) Interaktionspartner

  1. SIRT7 (zeige SIRT7 Proteine) inhibits TR4 (zeige NR2C2 Proteine) degradation by deacetylation of DDB1.

  2. the c-Abl (zeige ABL1 Proteine) non-receptor kinase phosphorylates DDB1 at residue Tyr (zeige TYR Proteine)-316 to recruit a small regulatory protein, DDA1 (zeige DDA1 Proteine), leading to increased substrate ubiquitination

  3. knockdown of DCAF7 (zeige DCAF7 Proteine) reduced the degradation of DNA ligase I (zeige LIG1 Proteine) in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I (zeige LIG1 Proteine) by Cul4-DDB1 and DCAF7 (zeige DCAF7 Proteine). In contrast, a different E3 ubiquitin ligase (zeige MUL1 Proteine) regulates FEN-1 (zeige FEN1 Proteine) turnover.

  4. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (zeige UNG Proteine) (cyclin U (zeige CCNO Proteine)) complex.

  5. Our data are consistent with the idea that the CUL4A (zeige CUL4A Proteine)/B-DDB1-CRBN (zeige CRBN Proteine) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (zeige CLCN1 Proteine) channels.

  6. These results revealed a novel role of DDB in H3K56Ac deacetylation during early step of NER (zeige NR1H2 Proteine) and the existence of active functional cross-talk between DDB-mediated damage recognition and H3K56Ac deacetylation.

  7. The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1-containing E3 ligase complex.

  8. Data support a model wherein DDB1 and DDB2 (zeige DDB2 Proteine) cooperate to repress Bcl-2 (zeige BCL2 Proteine) transcription. DDB2 (zeige DDB2 Proteine) recognizes and binds to the Bcl-2 (zeige BCL2 Proteine) P1 promoter, and HDAC1 (zeige HDAC1 Proteine) is recruited through the DDB1 subunit associated with DDB2 (zeige DDB2 Proteine) to deacetylate histone H3K9.

  9. The study presents the crystal structure of human CRBN (zeige CRBN Proteine) bound to DDB1 and the drug lenalidomide.

  10. CUL4A (zeige CUL4A Proteine)-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor (zeige PEX7 Proteine) Pex7p.

Cow (Bovine) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) Interaktionspartner

  1. Bovine herpesvirus-1 VP8 interacts with DDB1 and is monoubiquitinated during infection.

Caenorhabditis elegans (C. elegans) Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) Interaktionspartner

  1. Caenorhabditis elegans DDB-1 is required for the degradation of CDT-1 (zeige CDT1 Proteine) during S phase. DDB-1 interacts specifically with CUL-4 but not with other C. elegans cullins.

  2. Data show that SKN-1 protein levels, nuclear accumulation, and activity are repressed by the WD40 repeat protein WDR-23, which interacts with the CUL-4/DDB-1 ubiquitin ligase to presumably target the transcription factor for proteasomal degradation.

DDB1 Protein Überblick

Protein Überblick

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Alternative names and synonyms associated with DDB1

  • damage-specific DNA binding protein 1, 127kDa (DDB1)
  • damage-specific DNA binding protein 1, 127kDa (ddb1)
  • DNA damage-binding protein 1-like (LOC100187356)
  • damage specific DNA binding protein 1 (Ddb1)
  • damage-specific DNA binding protein 1, 127kDa (Ddb1)
  • Protein DDB-1 (ddb-1)
  • 127kDa Protein
  • AA408517 Protein
  • ddb1 Protein
  • DDBA Protein
  • p127-Ddb1 Protein
  • UV-DDB1 Protein
  • XAP1 Protein
  • XPCE Protein
  • XPE Protein
  • XPE-BF Protein

Bezeichner auf Proteinebene für DDB1

damage-specific DNA binding protein 1, 127kDa , DNA damage-binding protein 1-like , DDB p127 subunit , DNA damage-binding protein 1 , DNA repair protein , UV-damaged DNA-binding factor , damage-specific DNA-binding protein 1 , damage-specific DNA-binding protein, DNA repair , damaged-DNA recognition protein 1 , DNA damage-binding protein a , HBV X-associated protein 1 , UV-DDB 1 , UV-damaged DNA-binding protein 1 , XAP-1 , XPE-binding factor , xeroderma pigmentosum group E-complementing protein , damage specific DNA binding protein 1

GENE ID SPEZIES
100059606 Equus caballus
451234 Pan troglodytes
100135265 Xenopus (Silurana) tropicalis
100187356 Ciona intestinalis
100354475 Oryctolagus cuniculus
100468274 Ailuropoda melanoleuca
13194 Mus musculus
1642 Homo sapiens
476067 Canis lupus familiaris
511951 Bos taurus
64470 Rattus norvegicus
374050 Gallus gallus
100173610 Pongo abelii
178156 Caenorhabditis elegans
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