DNA Cross-Link Repair 1C ELISA Kits (DCLRE1C)
Auf www.antikoerper-online.de finden Sie aktuell 0 DNA Cross-Link Repair 1C (DCLRE1C) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DCLRE1C Antikörper (86) und DCLRE1C Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 99 DCLRE1C Produkte verfügbar.
9930121L06Rik, A-SCID, AI661365, Art, artemis, DCLREC1C, hSNM1C, nuclease, RS-SCID, SCIDA, SNM1C, Snm1l
list all ELISA KIts Gen GeneID UniProt
Human DCLRE1C DCLRE1C 64421 Q96SD1
Ratte DCLRE1C DCLRE1C 259171 Q5XIX3
Maus DCLRE1C DCLRE1C 227525 Q8K4J0

Weitere Synonyme anzeigen

Weitere ELISA Kits für DCLRE1C Interaktionspartner

Human DNA Cross-Link Repair 1C (DCLRE1C) Interaktionspartner

  1. An N-terminal fragment comprising the catalytic domain can interact both with itself and with a C-terminal fragment. Amino acid exchanges N456A+S457A+E458Q in the C terminus of full-length SCIDA resulted in unmasking of the N terminus and in increased SCIDA activity in cellular V(D)J recombination assays.

  2. Data demonstrate that DCLRE1C mutations can cause a phenotype presenting as only antibody deficiency.

  3. DCLRE1C and NCF1 (zeige NCF1 ELISA Kits) mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  4. the nature and location of mutations correlate with the clinical phenotype of severe combined immunodeficiency (zeige PRKDC ELISA Kits)

  5. uncovered a nuclease, Artemis, as a PTIP (zeige PAXIP1 ELISA Kits)-binding protein

  6. the 5'-exonuclease (zeige EXO1 ELISA Kits) is intrinsic to ARTEMIS, making it relevant to the role of ARTEMIS in nonhomologous DNA end joining

  7. DNA ligase IV (zeige LIG4 ELISA Kits) and Artemis act cooperatively to promote nonhomologous end-joining

  8. 2 siblings are described with combined immunodeficiency (CID (zeige CENPA ELISA Kits)) and immunodysregulation caused by compound heterozygous Artemis mutations.

  9. Artemis levels significantly influence radiation toxicity in human cells

  10. Our findings indicate a novel function of Artemis as a molecular switch that converts stalled replication forks harboring single-stranded gap DNA lesions into double-strand breaks, thereby activating the ATM (zeige ATM ELISA Kits) signaling pathway

Mouse (Murine) DNA Cross-Link Repair 1C (DCLRE1C) Interaktionspartner

  1. ATM (zeige ATM ELISA Kits) phosphorylates DNA-PKcs (zeige PRKDC ELISA Kits) to recruit Artemis and promote end-processing.

  2. we present T(-)B(-)NK(+) severe combined immunodeficiency (SCID (zeige PRKDC ELISA Kits)) phenotype after spontaneously occurring modification of Artemis gene in mice.

  3. deficient mice have a phenotype similar to that of DNA-PKcs (zeige PRKDC ELISA Kits)-deficient mice-including severe combined immunodeficiency (zeige PRKDC ELISA Kits) associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)

  4. Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis].

  5. Artemis/p53 (zeige TP53 ELISA Kits)-deficient mouse tumors lacked der(12 (zeige SLC29A2 ELISA Kits))t(12;15) translocations and c-myc (zeige MYC ELISA Kits) amplification.

  6. V(D)J and DNA repair defects seen in this Artemis-deficient mouse model are direct evidence that defective Artemis is the pathologic mechanism for the immunodeficiency phenotype of SCID (zeige PRKDC ELISA Kits) in Athabascan-speaking Native Americans.

  7. DNA-PK has Artemis-independent functions in class switch recombination and normal development

  8. Since Art deficient mice represent a model for radiation-sensitive severe combined immunodeficiency (zeige PRKDC ELISA Kits), we suggest that these patients may be at risk for both lymphoid and non-lymphoid cancers.

  9. DNA-PKcs (zeige PRKDC ELISA Kits) and Artemis open AAV inverted terminal repeat (ITR (zeige GPR180 ELISA Kits)) hairpin loops in a tissue-dependent manner.

  10. both DNA-PKcs (zeige PRKDC ELISA Kits) and, unexpectedly, Artemis are necessary for joining a subset of activation-induced cytidine deaminase (zeige AICDA ELISA Kits) (AID)-dependent DNA double-strand breaks

DCLRE1C Antigen-Profil

Beschreibung des Gens

This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity\; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

Alternative names and synonyms associated with DCLRE1C

  • DNA cross-link repair 1C (DCLRE1C) Elisa Kit
  • DNA cross-link repair 1C (Dclre1c) Elisa Kit
  • DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c) Elisa Kit
  • 9930121L06Rik Elisa Kit
  • A-SCID Elisa Kit
  • AI661365 Elisa Kit
  • Art Elisa Kit
  • artemis Elisa Kit
  • DCLREC1C Elisa Kit
  • hSNM1C Elisa Kit
  • nuclease Elisa Kit
  • RS-SCID Elisa Kit
  • SCIDA Elisa Kit
  • SNM1C Elisa Kit
  • Snm1l Elisa Kit

Bezeichner auf Proteinebene für DCLRE1C

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) , artemis protein , protein artemis , DNA cross-link repair 1C , protein artemis-like , DNA cross-link repair 1C protein , PSO2 homolog , SNM1 homolog C , SNM1-like protein , severe combined immunodeficiency, type a (Athabascan) , chSNM1C , Artemis protein , DNA cross-link repair 1A, PSO2 homolog , artemis , mArt

697493 Macaca mulatta
100056337 Equus caballus
100085149 Ornithorhynchus anatinus
100469797 Ailuropoda melanoleuca
100579542 Nomascus leucogenys
64421 Homo sapiens
517886 Bos taurus
259171 Rattus norvegicus
487123 Canis lupus familiaris
430764 Gallus gallus
100173437 Pongo abelii
227525 Mus musculus
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