anti-DCLRE1C (DCLRE1C) Antikörper

Bezeichnung:
anti-DNA Cross-Link Repair 1C Antikörper (DCLRE1C)
Auf www.antikoerper-online.de finden Sie aktuell 89 DNA Cross-Link Repair 1C (DCLRE1C) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen DCLRE1C Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 102 DCLRE1C Produkte verfügbar.
Synonyme:
9930121L06Rik, A-SCID, AI661365, Art, artemis, DCLREC1C, hSNM1C, nuclease, RS-SCID, SCIDA, SNM1C, Snm1l

Meistgesuchte Reaktivitäten zu anti-DCLRE1C (DCLRE1C) Antikörper

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anti-Human DCLRE1C Antikörper:

anti-Rat (Rattus) DCLRE1C Antikörper:

anti-Mouse (Murine) DCLRE1C Antikörper:

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Am meisten referenzierte anti-DCLRE1C Antikörper

  1. Human Polyclonal DCLRE1C Primary Antibody für EIA, IHC (p) - ABIN950523 : Beucher, Birraux, Tchouandong, Barton, Shibata, Conrad, Goodarzi, Krempler, Jeggo, Löbrich: ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. in The EMBO journal 2009 (PubMed)
    Zeige alle 3 Referenzen für 950523

  2. Human Polyclonal DCLRE1C Primary Antibody für IHC (p), WB - ABIN653693 : Rivera-Munoz, Soulas-Sprauel, Le Guyader, Abramowski, Bruneau, Fischer, Pâques, de Villartay: Reduced immunoglobulin class switch recombination in the absence of Artemis. in Blood 2009 (PubMed)
    Zeige alle 3 Referenzen für 653693

  3. Human Polyclonal DCLRE1C Primary Antibody für WB - ABIN151340 : Davies, Pettijohn, Fike, Wang, Nahas, Tunuguntla, Hu, Gatti, McCurdy: Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. in Arthritis and rheumatism 2012 (PubMed)

  4. Human Polyclonal DCLRE1C Primary Antibody für IHC, ELISA - ABIN1531298 : Moshous, Callebaut, de Chasseval, Corneo, Cavazzana-Calvo, Le Deist, Tezcan, Sanal, Bertrand, Philippe, Fischer, de Villartay: Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. in Cell 2001 (PubMed)

  5. Cow (Bovine) Polyclonal DCLRE1C Primary Antibody für WB - ABIN2784440 : Bethke, Murray, Webb, Schoemaker, Muir, McKinney, Hepworth, Dimitropoulou, Lophatananon, Feychting, Lönn, Ahlbom, Malmer, Henriksson, Auvinen, Kiuru, Salminen, Johansen, Christensen et al.: Comprehensive analysis of DNA repair gene variants and risk of meningioma.... in Journal of the National Cancer Institute 2008 (PubMed)

Weitere Antikörper gegen DCLRE1C Interaktionspartner

Human DNA Cross-Link Repair 1C (DCLRE1C) Interaktionspartner

  1. An N-terminal fragment comprising the catalytic domain can interact both with itself and with a C-terminal fragment. Amino acid exchanges N456A+S457A+E458Q in the C terminus of full-length SCIDA resulted in unmasking of the N terminus and in increased SCIDA activity in cellular V(D)J recombination assays.

  2. Data demonstrate that DCLRE1C mutations can cause a phenotype presenting as only antibody deficiency.

  3. DCLRE1C and NCF1 (zeige NCF1 Antikörper) mutations have been found by whole-genome sequencing to cause primary immunodeficiency in unrelated patients.

  4. the nature and location of mutations correlate with the clinical phenotype of severe combined immunodeficiency (zeige PRKDC Antikörper)

  5. uncovered a nuclease, Artemis, as a PTIP (zeige PAXIP1 Antikörper)-binding protein

  6. the 5'-exonuclease (zeige EXO1 Antikörper) is intrinsic to ARTEMIS, making it relevant to the role of ARTEMIS in nonhomologous DNA end joining

  7. DNA ligase IV (zeige LIG4 Antikörper) and Artemis act cooperatively to promote nonhomologous end-joining

  8. 2 siblings are described with combined immunodeficiency (CID (zeige CENPA Antikörper)) and immunodysregulation caused by compound heterozygous Artemis mutations.

  9. Artemis levels significantly influence radiation toxicity in human cells

  10. Our findings indicate a novel function of Artemis as a molecular switch that converts stalled replication forks harboring single-stranded gap DNA lesions into double-strand breaks, thereby activating the ATM (zeige ATM Antikörper) signaling pathway

Mouse (Murine) DNA Cross-Link Repair 1C (DCLRE1C) Interaktionspartner

  1. ATM (zeige ATM Antikörper) phosphorylates DNA-PKcs (zeige PRKDC Antikörper) to recruit Artemis and promote end-processing.

  2. we present T(-)B(-)NK(+) severe combined immunodeficiency (SCID (zeige PRKDC Antikörper)) phenotype after spontaneously occurring modification of Artemis gene in mice.

  3. deficient mice have a phenotype similar to that of DNA-PKcs (zeige PRKDC Antikörper)-deficient mice-including severe combined immunodeficiency (zeige PRKDC Antikörper) associated with defects in opening and joining V(D)J coding hairpin ends and increased cellular ionizing radiation sensitivity (artemis)

  4. Data show that Artemis appears to be required for a subset of nonhomologous DNA end joining reactions that require end processing [Artemis].

  5. Artemis/p53 (zeige TP53 Antikörper)-deficient mouse tumors lacked der(12 (zeige SLC29A2 Antikörper))t(12;15) translocations and c-myc (zeige MYC Antikörper) amplification.

  6. V(D)J and DNA repair defects seen in this Artemis-deficient mouse model are direct evidence that defective Artemis is the pathologic mechanism for the immunodeficiency phenotype of SCID (zeige PRKDC Antikörper) in Athabascan-speaking Native Americans.

  7. DNA-PK has Artemis-independent functions in class switch recombination and normal development

  8. Since Art deficient mice represent a model for radiation-sensitive severe combined immunodeficiency (zeige PRKDC Antikörper), we suggest that these patients may be at risk for both lymphoid and non-lymphoid cancers.

  9. DNA-PKcs (zeige PRKDC Antikörper) and Artemis open AAV inverted terminal repeat (ITR (zeige GPR180 Antikörper)) hairpin loops in a tissue-dependent manner.

  10. both DNA-PKcs (zeige PRKDC Antikörper) and, unexpectedly, Artemis are necessary for joining a subset of activation-induced cytidine deaminase (zeige AICDA Antikörper) (AID)-dependent DNA double-strand breaks

DCLRE1C Antigen-Profil

Beschreibung des Gens

This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity\; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).

Alternative names and synonyms associated with DCLRE1C

  • DNA cross-link repair 1C (DCLRE1C) Antikörper
  • DNA cross-link repair 1C (Dclre1c) Antikörper
  • DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) (Dclre1c) Antikörper
  • 9930121L06Rik Antikörper
  • A-SCID Antikörper
  • AI661365 Antikörper
  • Art Antikörper
  • artemis Antikörper
  • DCLREC1C Antikörper
  • hSNM1C Antikörper
  • nuclease Antikörper
  • RS-SCID Antikörper
  • SCIDA Antikörper
  • SNM1C Antikörper
  • Snm1l Antikörper

Bezeichner auf Proteinebene für DCLRE1C

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) , artemis protein , protein artemis , DNA cross-link repair 1C , protein artemis-like , DNA cross-link repair 1C protein , PSO2 homolog , SNM1 homolog C , SNM1-like protein , severe combined immunodeficiency, type a (Athabascan) , chSNM1C , Artemis protein , DNA cross-link repair 1A, PSO2 homolog , artemis , mArt

GENE ID SPEZIES
697493 Macaca mulatta
100056337 Equus caballus
100085149 Ornithorhynchus anatinus
100469797 Ailuropoda melanoleuca
100579542 Nomascus leucogenys
64421 Homo sapiens
517886 Bos taurus
259171 Rattus norvegicus
487123 Canis lupus familiaris
430764 Gallus gallus
100173437 Pongo abelii
227525 Mus musculus
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