anti-BTB (POZ) Domain Containing 12 (BTBD12) Antikörper

Bezeichnung:
anti-BTB (POZ) Domain Containing 12 Antikörper (BTBD12)
Auf www.antikoerper-online.de finden Sie aktuell 28 BTB (POZ) Domain Containing 12 (BTBD12) Antikörper von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 32 BTB (POZ) Domain Containing 12 Produkte verfügbar.
Synonyme:
AI256635, AI426760, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Ratte BTBD12 BTBD12 302953  
BTBD12 84464 Q8IY92
BTBD12 52864 Q6P1D7

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Meistgesuchte Reaktivitäten zu anti-BTB (POZ) Domain Containing 12 (BTBD12) Antikörper

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Am meisten referenzierte anti-BTB (POZ) Domain Containing 12 Antikörper

  1. Human Polyclonal BTBD12 Primary Antibody für IP - ABIN440495 : Holloway, Mohan, Balmus, Sun, Modzelewski, Borst, Freire, Weiss, Cohen: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. in PLoS genetics 2011 (PubMed)
    Zeige alle 3 Referenzen für 440495

  2. Human Polyclonal BTBD12 Primary Antibody für ICC, IF - ABIN440496 : Wan, Yin, Horvath, Sarkar, Chen, Wu, Wan, Lu, Gu, Yu, Lue, Chang, Liu, Lei: SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. in Cell reports 2013 (PubMed)

Weitere Antikörper gegen BTB (POZ) Domain Containing 12 Interaktionspartner

Human BTB (POZ) Domain Containing 12 (BTBD12) Interaktionspartner

  1. Data suggest that dimeric GEN1 (zeige GEN1 Antikörper) binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81 (zeige MUS81 Antikörper)-EME1 (zeige EME1 Antikörper) resolving enzyme complex. (GEN1 (zeige GEN1 Antikörper) = Holliday junction 5' flap (zeige ALOX5AP Antikörper) endonuclease; SLX = structure-specific endonuclease subunit; MUS81 (zeige MUS81 Antikörper) = MUS81 (zeige MUS81 Antikörper) endonuclease; EME1 (zeige EME1 Antikörper) = essential meiotic endonuclease 1) [REVIEW]

  2. These data also indicate that HIV-1 and HIV-2 Vpr activate the DNA damage response through an SLX4-independent mechanism that remains uncharacterized.

  3. The functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.

  4. SLX4-SLX1 Protein-independent Down-regulation of MUS81 (zeige MUS81 Antikörper)-EME1 (zeige EME1 Antikörper) Protein by HIV-1 Viral Protein R (Vpr).

  5. Results identified homozygous mutations in FANCA (zeige FANCA Antikörper) and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.

  6. SLX4 (FANCP) and XPF (zeige ERCC4 Antikörper) (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (zeige PALB2 Antikörper) (FA) DNA repair pathway. Study has revealed that the global minor allele, SLX4(Y546C), is defective in this interaction.

  7. SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

  8. Identification and characterization of MUS81 (zeige MUS81 Antikörper) point mutations that abolish interaction with the SLX4 scaffold protein (zeige HOMER1 Antikörper).

  9. Vpr recruits the SLX4 endonuclease complex and Vpr-induced inappropriate activation of this complex leads to cell cycle arrest at the G2 phase.

  10. FANCP has versatile functions in genome maintenance, its mutations result in Fanconi anemia (zeige PALB2 Antikörper). (Review)

Mouse (Murine) BTB (POZ) Domain Containing 12 (BTBD12) Interaktionspartner

  1. Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.

  2. SLX4 is a tumor suppressor, which activates XPF (zeige ERCC4 Antikörper)-ERCC1 (zeige ERCC1 Antikörper) nuclease (zeige DCLRE1C Antikörper) specificity in DNA crosslink repair.

  3. Data indicate that SLX1 and MUS81 (zeige MUS81 Antikörper)-EME1 (zeige EME1 Antikörper) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  4. these data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM (zeige ATM Antikörper)

  5. mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia (zeige PALB2 Antikörper)

BTB (POZ) Domain Containing 12 (BTBD12) Antigen-Profil

Beschreibung des Gens

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Alternative names and synonyms associated with BTB (POZ) Domain Containing 12 (BTBD12)

  • SLX4 structure-specific endonuclease subunit (Slx4) Antikörper
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4) Antikörper
  • SLX4 structure-specific endonuclease subunit (SLX4) Antikörper
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4) Antikörper
  • AI256635 Antikörper
  • AI426760 Antikörper
  • BTBD12 Antikörper
  • D16Bwg1016e Antikörper
  • FANCP Antikörper
  • MUS312 Antikörper
  • RGD1566009 Antikörper

Bezeichner auf Proteinebene für BTBD12

BTB (POZ) domain containing 12 , SLX4 structure-specific endonuclease subunit homolog , structure-specific endonuclease subunit SLX4 , BTB/POZ domain-containing protein 12

GENE ID SPEZIES
302953 Rattus norvegicus
453866 Pan troglodytes
416665 Gallus gallus
512193 Bos taurus
84464 Homo sapiens
52864 Mus musculus
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