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We showed that the mutation frequency of RAD51C (zeige RAD51C ELISA Kits) in Japanese familial breast cancer cases was similar to that in Western countries and that the prevalence of deleterious mutation of PALB2 (zeige PALB2 ELISA Kits) was possibly lower. Furthermore, our results suggested that BRIP1 (zeige MRPL36 ELISA Kits) mutation frequency in Japan might differ from that in Western countries
Cells expressing FANCJ pathological mutants exhibited defective sister chromatid recombination with an increased frequency of long-tract gene conversions.
Ttruncating variants in BRIP1 (zeige MRPL36 ELISA Kits), and in particular p.Arg798Ter, are not associated with a substantial increase in breast cancer risk.
Germline mutation in BRIP1 (zeige MRPL36 ELISA Kits) gene is associated with melanoma.
diverse endogenous microsatellite signals were also lost upon replication stress after FANCJ depletion, and in FANCJ null patient cells.
Findings collectively demonstrate that microRNA-543 exerts its oncogene (zeige RAB1A ELISA Kits) function by directly targeting BRCA1-interacting protein 1 (zeige MRPL36 ELISA Kits) in cervical cancer.
we showed the essential role of HP1 (zeige DEFA1 ELISA Kits) in regulating HR through BRCA1/BARD1 (zeige BARD1 ELISA Kits)-mediated accumulation of FANCJ and CtIP (zeige RBBP8 ELISA Kits) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.
A variant at a potentially functional microRNA-binding site in BRIP1 (zeige MRPL36 ELISA Kits) was associated with risk of squamous cell carcinoma of the head and neck.
BRIP1 (zeige MRPL36 ELISA Kits) might be the gene involved in the onset of breast cancer in families that do not show BRACA1/2 mutations (Review)
FANCJ protein is important for the stability of FANCD2 (zeige FANCD2 ELISA Kits)/FANCI (zeige FANCI ELISA Kits) proteins and protects them from proteasome and caspase-3 (zeige CASP3 ELISA Kits) dependent degradation.
FANCJ play roles in spermatogenesis at two stages: firstly in the proliferative activity that gives rise to the full complement of testicular spermatogonia and secondly in the establishment of appropriate crossovers numbers during prophase I.
Review of the functions and disease associations of human FANCJ.
Compares the human homolog to other members of the RecQ helicase (zeige DNA2 ELISA Kits) family
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
BRCA1 interacting protein C-terminal helicase 1
, fanconi anemia group J protein
, Fanconi anemia J
, complementation group J
, Fanconi anemia group J protein-like
, ATP-dependent RNA helicase BRIP1
, BRCA1-associated C-terminal helicase 1
, BRCA1-binding helicase-like protein BACH1
, BRCA1/BRCA2-associated helicase 1
, Fanconi anemia group J protein
, Fanconi anemia group J protein homolog